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Journal of Polymer Research
Published in: Journal of Polymer Research 12/2018

01-12-2018 | ORIGINAL PAPER

Click synthesis of glycosylated porphyrin-cored PAMAM dendrimers with specific recognition and thermosensitivity

Authors: Dan-Dan Chang, Wei-He Yang, Xiao-Hui Dai, Ji-Xiang Wang, Li Chen, Jian-Ming Pan, Yong-Sheng Yan, Yi-Rong Dai

Published in: Journal of Polymer Research | Issue 12/2018

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Abstract

Glycoporphyrin dendrimers have received increasing attentions due to their distinct physical and chemistry properties, such as fluorescence and water solubility. They also acted as a promising photodynamic therapy (PDT) sensitizer and used in the study of carbohydrate-protein interaction. In this study, different generations of porphyrin-cored dendrimers consisting of glycosylated siloxane-poly (amido amine) typed dendron (PP-Si-PAMAM-Dm-Lac, m = 1, 2, and 3), multifunctional specific-targeting sensitizers, had been synthesized via click reaction. The structure of PP-Si-PAMAM-Dm-Lac was characterized by 1H NMR, GPC, FT-IR, UV-vis and fluorescence analyses. This glycoporphyrin dendrimers, not only obtained high fluorescence quantum yield and singlet oxygen production efficiency, but also showed specific recognition of lectin and remarkable temperature-responsive property (20–80 °C). These properties proved a facile click synthetic strategy of glycosylated siloxane-poly (amido amine) typed dendrimers with multiple functions as a promising tumor-selective photsensitizer (PS) for PDT and also allow applications in highly sensitive fluorescent probes over a larger temperature window.
previous article Graphene/polyethylene terephthalate nanocomposites with enhanced mechanical and thermal properties
next article A computational and experimental approach to develop minocycline-imprinted hydrogels and determination of their drug delivery performances

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Appendix
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Metadata
Title
Click synthesis of glycosylated porphyrin-cored PAMAM dendrimers with specific recognition and thermosensitivity
Authors
Dan-Dan Chang
Wei-He Yang
Xiao-Hui Dai
Ji-Xiang Wang
Li Chen
Jian-Ming Pan
Yong-Sheng Yan
Yi-Rong Dai
Publication date
01-12-2018
Publisher
Springer Netherlands
Published in
Journal of Polymer Research / Issue 12/2018
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-018-1640-1

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