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Journal of Polymer Research

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01-12-2018 | ORIGINAL PAPER

A computational and experimental approach to develop minocycline-imprinted hydrogels and determination of their drug delivery performances

Authors: Büsra Eroglu, Dilek Dalgakiran, Tugce Inan, Ozge Kurkcuoglu, F. Seniha Güner

Published in: Journal of Polymer Research | Issue 12/2018

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Abstract

In this study, minocycline-imprinted hydrogels are developed for controlled drug delivery in ocular disease treatments. An integrated computational and experimental study are conducted for investigating the relationship between design parameters and the drug loading/release performance of hydrogels. First, suitable functional monomers are determined for successful drug-imprinting by studying pre-polymerization conditions with full-atom molecular dynamics (MD) simulations. MD simulations suggest that acrylic acid and itaconic acid are suitable monomers for imprinting minocycline. Then, minocycline-imprinted hydrogels are synthesized with acrylic acid, commonly used in hydrogels, and three different amounts of cross-linker ethylene glycol dimethacrylate, 1, 2 and 3 mol%. All hydrogels are characterized and their drug loading and release performances are determined. Our computational and experimental calculations indicate an optimum cross-linker amount of 2 mol% for controlled minocycline release from imprinted hydrogels with an imprinting factor of almost 3. Finally, the drug release kinetics are determined by Korsmeyer-Peppas model.

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Title: A computational and experimental approach to develop minocycline-imprinted hydrogels and determination of their drug delivery performances
Authors: Büsra Eroglu
Dilek Dalgakiran
Tugce Inan
Ozge Kurkcuoglu
F. Seniha Güner
Publication date: 01-12-2018
Publisher: Springer Netherlands
Published in: Journal of Polymer Research / Issue 12/2018
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-018-1647-7

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