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Journal of Polymer Research
Published in: Journal of Polymer Research 12/2018

01-12-2018 | ORIGINAL PAPER

Development of pH-sensitive and antibacterial gelatin/citric acid/Ag nanocomposite hydrogels with potential for biomedical applications

Authors: Nima Shafagh, Mohammad Sabzi, Mohammad Javad Afshari

Published in: Journal of Polymer Research | Issue 12/2018

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Abstract

This work aimed to prepare pH-sensitive and antibacterial drug releasing systems through a completely green route. To achieve this, the gelatin natural biopolymer was crosslinked with citric acid in the presence of Ag nanoparticles (NPs). Interestingly, Ag NPs formation and gelatin crosslinking were simultaneously occurred during annealing of samples without need for any toxic chemicals, which were confirmed by FTIR, UV-vis spectra, SEM and TEM observations. In addition, potential of the citric acid crosslinked-gelatin/Ag nanocomposite hydrogels was successfully explored for drug delivery applications using cefixime as a model drug. It was found that these hydrogels have pH-dependent swelling and drug release behavior with higher drug release at pH 7.4 compared to pH 1.2. Also, an antibacterial effect against the E. coli and S. aureus microorganisms was achieved by incorporation of Ag NPs into hydrogels. These hydrogels can be considered as stimuli responsive materials for oral drug delivery and wound dressing applications.
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Metadata
Title
Development of pH-sensitive and antibacterial gelatin/citric acid/Ag nanocomposite hydrogels with potential for biomedical applications
Authors
Nima Shafagh
Mohammad Sabzi
Mohammad Javad Afshari
Publication date
01-12-2018
Publisher
Springer Netherlands
Published in
Journal of Polymer Research / Issue 12/2018
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-018-1661-9

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