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Journal of Materials Engineering and Performance

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03-06-2021

Cold-Plasma-Sterilized Nanostructured Ti6Al4V: Effect on Nanostructured Surface Morphology and Osteogenic Differentiation of Bone-Marrow-Derived Mesenchymal Stem Cells

Authors: Leonardo Marasca Antonini, Antonio Shigueaki Takimi, Vanessa Pinheiro Amaral, Melissa Camassola, Célia de Fraga Malfatti

Published in: Journal of Materials Engineering and Performance | Issue 10/2021

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Abstract

The cold plasma sterilization is an alternative sterilization process that does not modify the morphological properties of nanostructured surfaces of titanium and its alloys. This study aims to evidence the effect of surface morphology of the cold-plasma-sterilized nanostructured Ti6Al4V on the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs). The surface treatments on Ti6Al4V used were sanding and electropolishing in a H₂SO₄/HF/glycerin solution. The samples were characterized by AFM, optical interferometry, and wettability. BM-MSCs were cultured for 14 days and tested for cell adhesion, metabolic activity, ALP activity, and mineralization. Results demonstrated that the nanostructured morphology of Ti6Al4V remained intact after the sterilization and promoted a more hydrophilic surface, which contributed to the increase in the metabolic activity, and to osteogenesis of BM-MSCs, as well as to the extracellular matrix mineralization. The bacteriological and mycological tests showed that bacteria, fungi, and yeasts were not detected after cold plasma sterilization.

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Title: Cold-Plasma-Sterilized Nanostructured Ti6Al4V: Effect on Nanostructured Surface Morphology and Osteogenic Differentiation of Bone-Marrow-Derived Mesenchymal Stem Cells
Authors: Leonardo Marasca Antonini
Antonio Shigueaki Takimi
Vanessa Pinheiro Amaral
Melissa Camassola
Célia de Fraga Malfatti
Publication date: 03-06-2021
Publisher: Springer US
Published in: Journal of Materials Engineering and Performance / Issue 10/2021
Print ISSN: 1059-9495
Electronic ISSN: 1544-1024
DOI: https://doi.org/10.1007/s11665-021-05903-0

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