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2019 | OriginalPaper | Chapter

55. Collagen-Based Hydrogels and Their Applications for Tissue Engineering and Regenerative Medicine

Authors : Sorina Dinescu, Madalina Albu Kaya, Leona Chitoiu, Simona Ignat, Durmus Alpaslan Kaya, Marieta Costache

Published in: Cellulose-Based Superabsorbent Hydrogels

Publisher: Springer International Publishing

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Abstract

A promising solution for soft tissue regeneration is tissue engineering, a multidisciplinary field of research which involves the use of biomaterials, growth factors, and stem cells in order to repair, replace, or regenerate tissues and organs damaged by injury or disease. The success of tissue engineering (TE) depends on the composition and microstructure of the used scaffolds. Ideally, scaffolds have to be similar to natural tissues. Collagen is the major component of the extracellular matrix of most soft tissues. The interactions between collagen and cells are vital in the wound healing process and in adult tissue remodeling, collagen being able to support differentiation and maintenance of cellular phenotype. As a natural molecule, collagen possesses the major advantage of being biodegradable, biocompatible, easily available, and highly versatile and presents low antigenicity. This chapter aims to present an overview on the structure, properties, and biomedical applications of collagen hydrogels. Moreover, it introduces the reader to the latest research in the field of tissue engineering related to collagen. It also displays the results we obtained as a joint bioengineering group on collagen hydrogels designed for soft (ATE) or cartilage tissue engineering (CTE) applications: type I collagen hydrogels improved with either silk sericin (CollSS) or with pro-chondrogenic factors – hyaluronic acid and chondroitin sulfate (CollSSHACS). Results indicated in both cases the positive influence of sericin on the interaction between cells and the surface of the hydrogels. In the absence of HA and CS, specific chondrogenic inducers, CollSS hydrogel is adapted for soft tissue reconstruction, whether the addition of HA and CS transforms CollSSHACS into a suitable hydrogel formula for semihard tissue repair via modern strategies in tissue engineering and regenerative medicine.

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Title: Collagen-Based Hydrogels and Their Applications for Tissue Engineering and Regenerative Medicine
Authors: Sorina Dinescu
Madalina Albu Kaya
Leona Chitoiu
Simona Ignat
Durmus Alpaslan Kaya
Marieta Costache
Publisher: Springer International Publishing
Book: Cellulose-Based Superabsorbent Hydrogels
Print ISBN: 978-3-319-77829-7

Electronic ISBN: 978-3-319-77830-3

Copyright Year: 2019
DOI: https://doi.org/10.1007/978-3-319-77830-3_54

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