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2020 | OriginalPaper | Chapter

Comparison of Corneal Morphologic Parameters and High Order Aberrations in Keratoconus and Normal Eyes

Authors : Jose Sebastián Velázquez, Francisco Cavas, Jose Miguel Bolarín, Jorge Alió

Published in: Bioinformatics and Biomedical Engineering

Publisher: Springer International Publishing

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Abstract

The aim of this study is evaluating the influence of corneal geometry in the optical system’s aberrations, and its usefulness as diagnostic criterion for keratoconus.159 normal eyes (normal group, mean age 37.8 ± 11.6 years) and 292 eyes with the diagnosis of keratoconus (keratoconus group, mean age 42.2 ± 17.6 years) were included in this study. All eyes received a comprehensive ophthalmologic examination. A virtual 3D model of each eye was made using CAD software and different anatomical parameters related with surface and volume were measured. Statistically significant differences were found for all anatomical parameters (all p < 0.001). AUROC analysis showed that all parameters reached values above 0.7, with the exception of the total corneal surface area (TCSAA-S). In conclusion, the methodology explained in this research, that bases in anatomical parameters obtained from a virtual corneal model, allow to analyze the diagnostic value of corneal geometry correlation with optical aberrations in keratoconus pathology.

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Title: Comparison of Corneal Morphologic Parameters and High Order Aberrations in Keratoconus and Normal Eyes
Authors: Jose Sebastián Velázquez
Francisco Cavas
Jose Miguel Bolarín
Jorge Alió
Publisher: Springer International Publishing
Book: Bioinformatics and Biomedical Engineering
Print ISBN: 978-3-030-45384-8

Electronic ISBN: 978-3-030-45385-5

Copyright Year: 2020
DOI: https://doi.org/10.1007/978-3-030-45385-5_8

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