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Medical & Biological Engineering & Computing
Published in: Medical & Biological Engineering & Computing 9/2007

01-09-2007 | Original Article

Computer model for the optimization of AV and VV delay in cardiac resynchronization therapy

Authors: Matthias Reumann, Dima Farina, Raz Miri, Stephan Lurz, Brigitte Osswald, Olaf Dössel

Published in: Medical & Biological Engineering & Computing | Issue 9/2007

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Abstract

An optimal electrode position, atrio-ventricular (AV) and interventricular (VV) delay in cardiac resynchronization therapy (CRT) improves its success. An optimization strategy does not yet exist. A computer model of the Visible Man and a patient heart was used to simulate an atrio-ventricular and a left bundle branch block with 0%, 20% and 40% reduction in interventricular conduction velocity, respectively. The minimum error between physiological excitation and pathology/therapy was automatically computed for 12 different electrode positions. AV and VV delay timing was adjusted accordingly. The results show the importance of individually adjusting the electrode position as well as the timing delays to the patient’s anatomy and pathology, which is in accordance with current clinical studies. The presented methods and strategy offer the opportunity to carry out non-invasive, automatic optimization of CRT preoperatively. The model is subject to validation in future clinical studies.
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Metadata
Title
Computer model for the optimization of AV and VV delay in cardiac resynchronization therapy
Authors
Matthias Reumann
Dima Farina
Raz Miri
Stephan Lurz
Brigitte Osswald
Olaf Dössel
Publication date
01-09-2007
Publisher
Springer-Verlag
Published in
Medical & Biological Engineering & Computing / Issue 9/2007
Print ISSN: 0140-0118
Electronic ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-007-0230-x

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