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2020 | OriginalPaper | Chapter

Deep Learning Approach with Rotate-Shift Invariant Input to Predict Protein Homodimer Structure

Authors : Anna Hadarovich, Alexander Kalinouski, Alexander V. Tuzikov

Published in: Bioinformatics Research and Applications

Publisher: Springer International Publishing

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Abstract

The ability to predict protein complexes is important for applications in drug design and generating models of high accuracy in the cell. Recently deep learning techniques showed a significant success in protein structure prediction, but a protein docking problem is unsolved yet. We developed a two-staged approach which consists of deep convolutional neural network to predict protein contact map for homodimers and optimization procedure based on gradient descent to build the homodimer structure from the contact map. Neural network uses the distance map calculated as all pairwise Euclidian distances between CB atoms of protein 3D structure as input, which is invariant to rotation and translation. The network has a large receptive filed to capture patterns in contacts between residues. The suggested approach could be generalized to heterodimers because it does not depend on symmetry features inherent in homodimers. The presented algorithm could be also used for scoring protein homodimers models in docking.

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Title: Deep Learning Approach with Rotate-Shift Invariant Input to Predict Protein Homodimer Structure
Authors: Anna Hadarovich
Alexander Kalinouski
Alexander V. Tuzikov
Publisher: Springer International Publishing
Book: Bioinformatics Research and Applications
Print ISBN: 978-3-030-57820-6

Electronic ISBN: 978-3-030-57821-3

Copyright Year: 2020
DOI: https://doi.org/10.1007/978-3-030-57821-3_27

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