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Published in:
2016 | OriginalPaper | Chapter
Dendritic Nanomaterials for Therapeutic and Diagnostic Applications
Authors : Ja Hye Myung, Kevin A. Tam, Seungpyo Hong
Published in: Biomedical Engineering: Frontier Research and Converging Technologies
Publisher: Springer International Publishing
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Dendritic nanomaterials have attracted a great deal of scientific interest for use in various biomedical applications primarily due to their well-defined structure and capacity for multifunctionalization. In this chapter, we present a comprehensive overview of the recent advances in various dendrimers and their modified dendritic materials with a particular focus on their applications such as drug delivery, gene delivery, diagnostics and prognostics, and detoxification/prophylaxis. We also discuss the fundamentals of the biological interactions of dendritic nanomaterials in regard to non-specific cell interactions, multivalent binding, stimuli-responsive processes, and biodistribution. In addition, this chapter highlights the current drawbacks of dendrimers that have hindered their rapid clinical translation and introduce recent approaches to overcoming these challenges.