2016 | OriginalPaper | Buchkapitel
Dendritic Nanomaterials for Therapeutic and Diagnostic Applications
verfasst von : Ja Hye Myung, Kevin A. Tam, Seungpyo Hong
Erschienen in: Biomedical Engineering: Frontier Research and Converging Technologies
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
Dendritic nanomaterials have attracted a great deal of scientific interest for use in various biomedical applications primarily due to their well-defined structure and capacity for multifunctionalization. In this chapter, we present a comprehensive overview of the recent advances in various dendrimers and their modified dendritic materials with a particular focus on their applications such as drug delivery, gene delivery, diagnostics and prognostics, and detoxification/prophylaxis. We also discuss the fundamentals of the biological interactions of dendritic nanomaterials in regard to non-specific cell interactions, multivalent binding, stimuli-responsive processes, and biodistribution. In addition, this chapter highlights the current drawbacks of dendrimers that have hindered their rapid clinical translation and introduce recent approaches to overcoming these challenges.