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2014 | OriginalPaper | Chapter

83. Design, Synthesis and Biological Evaluation of the Novel Antitumor Agent 2-benzyl-3, 4-dihydroisoquinolin-1(2H)-one and Its Derivatives

Authors : Jian Lv, Lei Lv, Xiaomin Zhang, Yao Zhou, Kui Lu, Yifei lu, Yuou Teng, Hua Sun, Peng Yu

Published in: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Publisher: Springer Berlin Heidelberg

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Abstract

Tetrahydroisoquinoline and its derivatives have a wide range of biological activities, such as antitumor, antimicrobial, and analgesic properties and so on. Some tetrahydroisoquinoline alkaloid derivatives have been studied as antitumor drug molecules, but 2-benzyl-7-substituted-ethoxy]-3, 4-dihydro-1(2H)-isoquinolinone series have not been reported yet. In this paper, we would like to report the design, synthesis, and biological evaluation of the novel tetrahydroisoquinoline derivatives. Among those compounds, four new tetrahydroisoquinoline derivatives have not been reported before. All the newly synthesized compounds were characterized by 1H NMR and their antitumor activities were evaluated by using HT-29, K562 and HepG2 cell line. 2-Benzyl-7-[2-(tert-butyl-4-piperazinecarboxylate) ethoxy]-3, 4-dihydro-1(2H)-isoquinolinone demonstrated good antitumor activity against K562 cancer cell with an IC50 of 1.58 μM.

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Metadata
Title
Design, Synthesis and Biological Evaluation of the Novel Antitumor Agent 2-benzyl-3, 4-dihydroisoquinolin-1(2H)-one and Its Derivatives
Authors
Jian Lv
Lei Lv
Xiaomin Zhang
Yao Zhou
Kui Lu
Yifei lu
Yuou Teng
Hua Sun
Peng Yu
Copyright Year
2014
Publisher
Springer Berlin Heidelberg
Book
Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Print ISBN: 978-3-642-37921-5

Electronic ISBN: 978-3-642-37922-2

Copyright Year: 2014

DOI
https://doi.org/10.1007/978-3-642-37922-2_83

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