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Microsystem Technologies

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05-01-2021 | Technical Paper

Development of spear-shaped microneedle and applicator for tip insertion into artificial skin

Authors: Mizuki Sakamoto, Yoshihiro Hasegawa, Mitsuhiro Shikida

Published in: Microsystem Technologies | Issue 10/2021

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Abstract

A micro-machined tip-separable microneedle structure fabricated using a molding process was placed on the end of a metal rod with the outer diameter of 2.0 mm to produce a spear-shaped microneedle, and an applicator for inserting this microneedle into the skin based on a commercially available stamp mechanism was developed. The fabricated spear-shaped microneedle with the needle holder was inserted into the stamp mechanism and a load cell was embedded between the push button and the microneedle for quantitatively evaluating the applied force during microneedle insertion. A PDMS sheet with the Young’s modulus of 0.8 MPa, similar to that of human skin, was used as the artificial skin sample. The tip part was separated from the base and successfully embedded into the skin when the relatively large force of 64.9 N was applied within the time period of 426 ms. The tip was completely embedded to the depth of 0.305 mm below the skin surface, and thus the puncture marks generated by the insertion were almost completely closed thanks to the elasticity of the PDMS at the surface.

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Campbell PK, Jones KE, Huber RJ, Horch KW, Normann RA (1991) A silicon-based three dimensional neural interface: manufacturing process for an intracortical electrode array. IEEE Trans Biomed Eng 38:758CrossRef

Gardeniers JGE, Berenschot JW, de Boer MJ, Yeshurun Y, Hefetz M, van ‘t Oever R, van den Berg A (2002) Silicon micromachined hollow microneedles for transdermal liquid transfer. Tech. digest. MEMS, Las Vegas, pp 141–144

Gingerich MD, Hetke JF, Anderson DJ, Wise KD, “A 256-site 3D CMOS microelectrode array for multipoint stimulation and recording in the central nervous system,” Tech. digest. of The 11th International Conference on Solid-State Sensors and Actuators (Trandcures 2001), June, Munich, Germany, pp. 416–419 (2001)

Griss P, Stemme G, “Novel, side opened out-plane microneedles for micro-fluidic transdermal interfacing,” Tech. Digest of MEMS 2002, Las Vegas, USA, pp. 467–470 (2002)

Henry S, McAllister DV, Allen MG, Prausnitz MR (1998) Micromachined needles for the transdermal delivery of drugs. In: Proc. micro electro mechanical systems workshop, pp. 494–498

Imaeda K, Bessho K, Shikida M (2015) Sharp tip-separable microneedle device for trans-dermal drug delivery systems. In: Technical digest of the 18th international conference on solid-state sensors and actuators (Transducers 2015), Anchorage, Alaska, June, pp. 1715–1717 (2015)

Kim J, Paik S-J, Wang P-C, Kim S-H, Allen MG (2011) Maskless fabrication of high aspect ratio structures by combination of micromolding and direct drawing. Tech. Digest of MEMS 2011, Cancun, Mexico, pp. 280–284

Najafi K, Wise KD, Mochizuki T (1985) A high-yield IC-compatible multichannel recording array. IEEE Trans Electron Devices 32:1206CrossRef

Paik S-J, Kim S-H, Wang P-C, Wester BA, Allen MG (2010) Dissolvable-tipped, drug-reservoir integrated microneedle array for transdermal drug delivery. Tech. Digest of MEMS 2010, Hong Kong, China, pp. 312–315 (2010)

Park J-H, Davis S, Yoon Y-K, Prausnitz MR, Allen MG (2003) Micromachined biodegradable microstructure. Tech. Digest of MEMS 2003, Kyoto, Japan, pp. 371–374

Petersen K (1982) Silicon as a mechanical material. In: Proc. IEEE, 70, 5, pp. 420–457

Roxhed N, Griss P, Stemme G (2005) Reliable in-vivo penetration and transdermal injection using ultra-sharp hollow microneedles. In: Tech. Digest of The 13th international conference on solid-state sensors and actuators (Transduceres 2005), pp. 213–216

Sakamoto M, Hasegawa Y, Taniguchi K, Shikida M (2019) Four-sided Tip-separable Micro-Needle device with large barb formed by anisotropic wet etching for trans-dermal drug delivery system. In: Tech. Dig. of the 20th international conference solid-state sensors, actuators and microsystems (Transducers2019), Berlin, Germany, Jun., pp. 1760–1763

Sakamoto M, Hasegawa Y, Taniguchi K, Shikida M (2020) Development of spear-shaped tip-separable microneedle device with guide tube for trans-dermal drug delivery system. In: Proceedings of 33rd international microprocesses and nanotechnology conference (MNC2020), Online, Nov, 2020-5-24 (2020)

Sakata M, Goryu A, Ikedo A, Harimoto T, Ishida M, Kawano T (2011) A vertical micro-scale light guiding silicon dioxide tube array for optical neurostimulator. In: Tech. Digest. MEMS 2011, Cancun, Mexico, pp. 1015–1018

Shandhi MMH, Leber M, Hogan A, Bhandari R, Negi S (2015) A Novel method of fabricating high channel density neural array for large neuronal mapping. In: Tech. digest the 18th international conference on solid-state sensors and actuators (Transducres2015), Anchorage, Alaska, June, pp. 1759–1762 (2015)

Shikida M, Odagaki M, Todoroki N, Ando M, Ishihara Y, Sato K, Asaumi K (2004) Non-photolithographic pattern transfer for fabricating arrayed 3-D microstructures by chemical anisotropic etching. Sens Actuat A 116:264–271CrossRef

Shikida M, Hasada T, Sato K (2006) Fabrication of densely arrayed micro-needles with flow channels by mechanical dicing and anisotropic wet etching. J Micromech Microeng 16:1740–1747CrossRef

Shikida M, Kitamura S, Miyake C, Bessho K (2014) Micromachined pyramidal shaped biodegradable microneedle and its skin penetration capability. Microsyst Technol 20:2239–2245CrossRef

Son Y, Lee HJ, Kim J, Lee CJ, Yoon E-S, Kim TG (2015) A new monolithically integrated multi-functional MEMS neural probe for optical stimulation and drug delivery. Estoril, Porgugal, pp 158–161 Technical Digest of MEMS 2015

Trautmann A, Heuck F, Denfeld R, Ruther P, Paul O (2006) Detachable silicon microneedle stamps for allergy skin prick testing. Tech. Digest of MEMS 2006. Istanbul, Turkey, pp 434–437

Title: Development of spear-shaped microneedle and applicator for tip insertion into artificial skin
Authors: Mizuki Sakamoto
Yoshihiro Hasegawa
Mitsuhiro Shikida
Publication date: 05-01-2021
Publisher: Springer Berlin Heidelberg
Published in: Microsystem Technologies / Issue 10/2021
Print ISSN: 0946-7076
Electronic ISSN: 1432-1858
DOI: https://doi.org/10.1007/s00542-020-05195-9

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