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The Emperor’s New Body: Seeking for a Blueprint of Limb Regeneration in Humans Read chapter Read first chapter

2011 | OriginalPaper | Chapter

Endothelial Progenitor Cells for Vascular Repair

Authors : Melissa A. Brown, Cindy S. Cheng, George A. Truskey

Published in: Stem Cell Engineering

Publisher: Springer Berlin Heidelberg

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Abstract

Endothelial progenitor cells (EPCs), present in the blood and bone marrow, represent a potential source of endothelial cells for repair of injured blood vessels, neovascularization, and tissue engineering. EPCs are present at low levels in peripheral blood, although their numbers increase in response to cytokines, VEGF, and statins. There are at least two types of EPCs characterized following in vitro culture: colony-forming unit ECs (CFU-ECs) and endothelial colony-forming cells (ECFCs). CFU-ECs appear early in culture, have limited ability to proliferate, and share markers for endothelial cells and monocytes. In contrast, ECFCs appear later in culture, grow rapidly, and to large numbers express only endothelial cell markers. This chapter examines the properties of these EPCs, in vitro and in vivo studies using these two cell types, and the potential of these EPCs for therapeutic applications.

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Metadata
Title
Endothelial Progenitor Cells for Vascular Repair
Authors
Melissa A. Brown
Cindy S. Cheng
George A. Truskey
Copyright Year
2011
Publisher
Springer Berlin Heidelberg
Book
Stem Cell Engineering

Print ISBN: 978-3-642-11864-7

Electronic ISBN: 978-3-642-11865-4

Copyright Year: 2011

DOI
https://doi.org/10.1007/978-3-642-11865-4_13