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2011 | OriginalPaper | Chapter

The Emperor’s New Body: Seeking for a Blueprint of Limb Regeneration in Humans

Authors : Ilya Digel, Aysegül Temiz Artmann

Published in: Stem Cell Engineering

Publisher: Springer Berlin Heidelberg

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Abstract

Aspiring to comprehend and control regeneration – the ability to recreate lost or damaged cells, tissues, organs or even limbs – has been the mind-boggling challenge for over 250 years. Regeneration is a common feature in many animal species, whereas its capacity in mammals is notoriously limited. The partial or complete loss of digits or limbs and the deformation of facial injuries profoundly affect the quality of life of the wounded and present a set of challenges for the medical community. This chapter is devoted to some of the problems and prospects of human limb regeneration. It briefly reviews the appearance of regenerative abilities in different tribes across the animal kingdom as well as the genes and cellular signaling pathways involved. Special emphasis is placed upon blastema and scar formation as well as on morphogenetic pattering.

The analysis of evolutionary manifestations of regeneration ability, the apparent relation to the embryonic development mechanisms, as well as consideration of some existing clinical approaches suggest the possibility to “awaken” the regeneration ability in mammals and even in human beings. The ultimate goal of further research will be to identify ways for enhancing the capacity for wound healing and tissue restoration in humans. This would open new exciting prospects for future regenerative medicine.

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Title: The Emperor’s New Body: Seeking for a Blueprint of Limb Regeneration in Humans
Authors: Ilya Digel
Aysegül Temiz Artmann
Publisher: Springer Berlin Heidelberg
Book: Stem Cell Engineering
Print ISBN: 978-3-642-11864-7

Electronic ISBN: 978-3-642-11865-4

Copyright Year: 2011
DOI: https://doi.org/10.1007/978-3-642-11865-4_1