Top

Published in:

2019 | OriginalPaper | Chapter

High-Throughput Analytics in the Function of Personalized Medicine

Authors : Djuro Josić, Tamara Martinović, Urh Černigoj, Jana Vidič, Krešimir Pavelić

Published in: Personalized Medicine in Healthcare Systems

Publisher: Springer International Publishing

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Rapid and highly reliable analysis of patient sample is the first premise and simultaneously the first step in the direction of right diagnosis and personalized treatment. However, this fact is frequently neglected. Despite this situation, almost unnoticed activities in this field started 55 years ago with the concept of a biosensor for fast monitoring of blood glucose and diabetes control, and blood glucose determination is still the driving force for optimization of these kinds of high-throughput analytical devices. The development of devices for high-throughput analytical methods for fast and accurate analysis started with the separation of molecules based on different size, charge and hydrophobicity and with the introduction of chromatographic and electrophoretic methods into clinical laboratories. The next step was their optimization towards the strategy for a fast analysis and miniaturization. One of the main tools for such kinds of analyses are different optimized supports and instruments for signal amplification that are used in such devices. The discovery and use of miniaturized chromatographic and electrophoretic systems based on monolithic supports was briefly discussed here. Their development in the direction of further miniaturization towards biosensors and nanobiosensors was also presented.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

previous chapter Patient–Doctor Relationship: Data Protection in the Context of Personalised Medicine

next chapter Bacteria—Human Interactions: Leads for Personalized Medicine

ESF Forward Look (2012).

Bošnjak et al. (2008).

Pavelić et al. (2016).

The Royal Swedish Academy of Sciences (2002).

Josić and Andjelković (2016).

Nobel Lectures Chemistry (1964).

Axén and Porath (1966).

Johansson et al. (1975).

Unger (1979) and Chang et al. (1976).

Josić et al. (1989).

Tennikova et al. (1990).

Hjertén et al. (1989).

Josić et al. (1992).

Josić et al. (1992) and Svec and Huber (2006).

Svec and Huber (2006) and Josić and Buchacher (2001).

Štrancar et al. (1996).

Podgornik et al. (2000).

Wu et al. (2001) and Švec and Lv (2015).

Ručević et al. (2006) and Opal et al. (2007).

Josić and Buchacher (2001).

Opal et al. (2007) and Chaaban et al. (2015).

Breen et al. (2012).

Pučić et al. (2011).

Brgles et al. (2011).

Burke et al. (1988).

Veeraragavan et al. (1991) and Manseth et al. (2004).

Husband et al. (2000).

Veeraragavan et al. (1991).

Manseth et al. (2004).

Brgles et al. (2011) and Šrajer Gajdošik et al. (2012).

Ahrends et al. (2010), Kotasinska et al. (2012) and Trusch et al. (2012).

Shu et al. (2012).

Šrajer Gajdošik et al. (2014).

Burnouf (2007).

Burnouf (2007) and Josić et al. (2000).

Cho (2015).

Schiel et al. (2011).

Černigoj et al. (2015).

Brown et al. (2010).

Brgles et al. (2011).

Brgles et al. (2011), Šrajer Gajdošik et al. (2012), Ahrends et al. (2010), Kotasinska et al. (2012), Trusch et al. (2012) and Josić and Clifton (2007).

Josić et al. (1992) and Abou-Rebyeh et al. (1991).

Štrancar et al. (1996).

Svec and Fréchet (1996).

Brgles et al. (2011), Ahrends et al. (2010) and Šrajer Gajdošik et al. (2014).

Ahrends et al. (2010).

Josić and Clifton (2007).

Trbojević-Akmačić et al. (2016).

Naldi et al. (2017).

Breen et al. (2012), Pučić et al. (2011), Naldi et al. (2017) and Breen et al. (2016).

Peterson et al. (2002).

Makaram et al. (2014).

Nayak et al. (2017).

Wang (2008).

Nayak et al. (2017), Wang (2008) and Witkowska Nery et al. (2016).

Zang et al. (2004).

Chen et al. (2013).

Sheng et al. (2012).

Odom et al. (2013).

Lusczek et al. (2017).

Champagne et al. (2016).

Cavally et al. (2017).

Vander Heiden et al. (2009).

Nayak et al. (2017), Du and Dong (2017) and Liu et al. (2010).

Wang (2008) and Witkowska Nery et al. (2016).

Clark et al. (2016).

Alves et al. (2016).

Zamperi et al. (2017) and Švec and Lv (2015).

Fu et al. (2017), Du and Dong (2017) and Ashley et al. (2017).

Wen et al. (2017).

Yang et al. (2017).

Du and Dong (2017).

Ashley et al. (2017).

Ručević et al. (2006).

Švec and Lv (2015) and Malik et al. (2013).

Huang et al. (2016a).

Fu et al. (2017).

Nayak et al. (2017), Wang (2008) and Witkowska Nery et al. (2016).

Wang (2008).

Witkowska Nery et al. (2016).

Lupinek et al. (2014).

Huang et al. (2016a).

Huang et al. (2016b).

Zhong et al. (2016).

Fu et al. (2017).

Du and Dong (2017).

Wen et al. (2017).

Jianrong et al. (2004).

MacKenzie et al. (2009) and Zeng et al. (2011).

Malik et al. (2013) and Jianrong et al. (2004).

MacKenzie et al. (2009) and Zeng et al. (2011).

Tiwari and Turner (2014).

Abou-Rebyeh H, Körber F, Schubert-Rehberg K, Reusch J, Josić D (1991) Carrier membrane as a stationary phase for affinity chromatography and kinetic studies of membrane bound enzymes. J Chromatogr B 566:341–350CrossRef

Ahrends R, Lichtner B, Bertsch A, Kohlbacher O, Hildebrand D, Trusch M, Schlüter H (2010) Application of displacement chromatography for the proteome analysis of a human plasma protein fraction. J Chromatogr A 1217:3321–3329CrossRef

Alves RC, Barroso MF, González-García MB, Oliveira MB, Delerue-Matos C (2016) New trends in food allergens detection: toward biosensing strategies. Crit Rev Food Sci Nutr 56:2304–2319CrossRef

Ashley J, Piekarska M, Segers C, Trinth L, Rodgers T, Willey R, Tothill IE (2017) An SPR based sensor for allergens detection. Biosens Bioelectron 88:109–113CrossRef

Axén R, Porath J (1966) Chemical coupling of enzymes to cross-linked dextran (“Sephadex”). Nature 210:367–369CrossRef

Bošnjak H, Pavelić K, Kraljević Pavelić S (2008) Towards preventive medicine. High-throughput methods from molecular biology are about to change daily clinical practice. EMBO Rep 9:1056–1060CrossRef

Breen L, Cao L, Eom L, Šrajer Gajdošik M, Camara L, Giacometti J, Dupuy D, Josić D (2012) High-throughput fractionation of human plasma for fast enrichment of low- and high-abundance proteins. Blood Trans 10(Suppl 2):S89–S100

Breen L, Pučić-Baković M, Vučković F, Reiding K, Trbojević-Akmačić I, Šrajer Gajdošik M, Cook MI, Lopez M, Wuhrer M, Camara LM, Andjelković U, Dupuy DE, Josić D (2016) IgG and IgM glycosylation patterns in patients undergoing image-guided tumor ablation. Biochim Biophys Acta Gen Subj 1860:1786–1794CrossRef

Brgles M, Clifton J, Walsh R, Huang F, Ručević M, Cao L, Hixson D, Müller E, Josić D (2011) Selectivity of monolithic supports under overloading conditions and their use for separation of human plasma and isolation of low abundance proteins. J Chromatogr A 1218:2389–2395CrossRef

Brown A, Bill J, Tully T, Radhamohan A, Dowd C (2010) Overloading ion-exchange membranes as a purification step for monoclonal antibodies. Biotechnol Appl Biochem 56:59–70CrossRef

Burke LTW, Mant CT, Hodges RS (1988) A novel approach to reversed-phase preparative high-performance liquid chromatography of peptides. J Liq Chromat 11:1229–1247CrossRef

Burnouf T (2007) Modern plasma fractionation. Transfusion Med Rev 21:101–117CrossRef

Cavally G, Justice JN, Boyle KE, D’Alessandro A, Eisenmesser EZ, Herrera JJ (2017) Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Proc Natl Acad Sci USA 114:2313–2318CrossRef

Černigoj U, Martinuč U, Cardoso S, Sekirnik R, Lendero Kranjc N, Štrancar A (2015) Sample displacement chromatography of plasmid DNA forms. J Chromatogr A 1414:103–109CrossRef

Chaaban H, Keshari RS, Silasi-Mansat R, Popescu NI, Mehta-D’Souza P, Lim Y-P, Lupu F (2015) Inter-α-inhibitor protein and its associated glycosaminolglycans protect against histone-induced injury. Blood 125:2286–2296CrossRef

Champagne DP, Hatle KM, Fortner KA, D’Alessandro A, Thornton TM, Yang R, Torraba D, Tomás-Cortázar J, Jun YW, Ahn KH, Hansen KC, Haynes L, Anguita J, Rincon M (2016) Fine tuning of CD8 (+) T cell mitochondrial metabolism by the respiratory chain repressor MCJ dictates protection to influenza virus. Immunity 44:1299–1311CrossRef

Chang S-H, Noel R, Regnier FE (1976) High speed ion exchange chromatography of proteins. Anal Chem 48:1839–1845CrossRef

Chen P, Peng Y, He M, Yan X-C, Zhang Y, Liu X-N (2013) Sensitive electrochemical detection of creatinine at disposable screnn-printed carbon electrode mixed with ferrocenemethanol. Int J Electrochem Sci 8:8931–8939

Cho W (2015) Displacement phenomena in lectin affinity chromatography. Anal Chem 87:9612–9620CrossRef

Clark KD, Zhang C, Anderson JL (2016) Sample preparation for bioanalytical and pharmaceutical analysis. Anal Chem 88:11262–11270CrossRef

Du Y, Dong S (2017) Nucleic acid biosensors: recent advances and perspectives. Anal Chem 89:189–215CrossRef

ESF Forward Look (2012) Personalised medicine for the European citizen. Towards more precise medicine for the diagnosis, treatment and prevention of disease (iPM). European Science Foundation, Strasbourg

Fu X, Chen L, Choo J (2017) Optical probes for ultrasensitive immunoassay. Anal Chem 89:124–137CrossRef

Hjertén S, Liao JL, Zhang R (1989) High-performance liquid chromatography on continuous polymer beds. J Chromatogr A 473:273–275CrossRef

Huang X, Aguilar ZP, Xu H, Li W, Xiong Y (2016a) Membrane-based lateral flow immunochromatograhic strip with nanoparticles as reporters for detection: a review. Biosens Bioelctron 75:166–180CrossRef

Huang H, Jiang D, Zhu P, Pi F, Ji J, Sun C, Sun J, Sun X (2016b) A novel mast cell co-culture microfluidic chip for the electrochemical evaluation of food allergen. Biosens Bioelctron 83:126–133CrossRef

Husband DL, Mant CT, Hodges RS (2000) Development of simultaneous purification methodology for multiple synthetic peptides by reversed-phase sample displacement chromatography. J Chromatogr A 893:81–94CrossRef

Jain KK (2008) The handbook of nanomedicine. Humana Press, Basel, pp 91–116CrossRef

Jianrong C, Yuging M, Nongyne H, Xiaohua W, Sijiao L (2004) Nanotechnology and biosensors. Biotech Adv 22:505–518CrossRef

Johansson KE, Blomqvist J, Hjertén S (1975) Purification of membrane proteins from Acholeplasma laidlawii by agarose suspension electrophoresis in Tween 20 and polyacrylamide and dextran gel electrophoresis in detergent-free media. J Biol Chem 250:2463–2469CrossRef

Josić D, Andjelković U (2016) The role of proteomics in personalized medicine. In: Bodiroga-Vukobrat N, Pavelić K, Rukavina D, Sander GG (eds) Personalised medicine: a new medical and social challenge (Europeanization and globalization). Springer International Publishing, Switzerland, pp 179–218CrossRef

Josić D, Buchacher A (2001) Application of monoliths as supports for affinity chromatography and fast enzymatic conversion. J Biochem Biophys Methods 49:153–174CrossRef

Josić D, Clifton JG (2007) Use of monolithic supports in proteomics technology. J Chromatogr A 1144:2–13CrossRef

Josić D, Zeilinger K, Lim Y-P, Raps M, Hofmann W, Reutter W (1989) Preparative isolation of glycoproteins from plasma membranes of different rat organs. J Chromatogr A 484:327–335CrossRef

Josić D, Reusch J, Löster K, Baum O, Reutter W (1992) High performance membrane chromatography of serum and plasma membrane proteins. J Chromatogr A 590:59–76CrossRef

Josić D, Hoffer L, Buchacher A, Schwill F, Biesert L, Klöcking H-P, Hellstern P, Rokicka-Milewska R, Klukowska A (2000) Manufacturing of prothrombin complex concentrate aiming a low thrombinicity. Thromb Res 100:433–441CrossRef

Kotasinska M, Richter W, Thiemann J, Schlüter H (2012) Cation exchange displacement batch chromatography of proteins guided by screening of protein purification parameters. Electrophoresis 35:3170–3176

Liu J, Chen C-F, Chang C-W, DeVoe DL (2010) Flow-through immunosensors using antibody-immobilized polymer monoliths. Biosens Bioelectron 26:182–188CrossRef

Lupinek C, Wollmann E, Baar A, Banerjee S, Breiteneder H, Broecker BM et al (2014) Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip. Methods 66:106–119CrossRef

Lusczek ER, Muratore SL, Dubick MA, Beilman J (2017) Assessment of key plasma metabolites in combat causalities. J Trauma Acute Care Surg 82:309–316CrossRef

MacKenzie R, Auzelyte V, Olliges S et al (2009) Nanowire development and characterization for applications in biosensing. In: Micheli G, Leblebici Y, Gijs M, Vörös J (eds) Nanosyst design & technology. Springer, pp 143–173

Makaram P, Owens D, Aceros J (2014) Trends in nanomaterial-based non-invasive diabetes sensing technologies. Diagnostica (Basel) 4:27–46

Malik P, Katyal V, Malik V, Asatkar A, Inwati G, Mukherjee TK (2013) ISRN nanobiosensors: concepts and variations nanomaterials. Article ID 327435

Manseth E, Skjervold PO, Flengsrud R (2004) Sample displacement chromatography of Atlantic Salmon (Salmo salar) thrombin. J Biochem Biophys Methods 60:39–47CrossRef

Naldi M, Černogoj U, Štrancar A, Bartolini M (2017) Towards automation in protein digestion: development of monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis. Talanta 167:143–157CrossRef

Nayak S, Blumenfeld NR, Laksanasopin T, Sia SK (2017) Point-of-care diagnostic: recent developments in connected age. Anal Chem 89:102–123CrossRef

Nobel Lectures Chemistry 1942–1962 (1964) Elsevier, Amsterdam

Odom SR, Howell MD, Silva GS, Nielsen VM, Grupta A, Shapiro NI, Talmor D (2013) Lactate clearance as a predictor of mortality in trauma patients. J Trauma Acute Care Surg 74:999–1004CrossRef

Opal SM, Lim Y-P, Siryaporn E, Moldawer LL, Pribble JP, Palardy JE, Souza S (2007) Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis. Crit Care Med 35:387–392CrossRef

Pavelić K, Sedić M, Pavelić Kraljević S (2016) Introduction to personalized medicine. In: Bodiroga-Vukobrat N, Pavelić K, Rukavina D, Sander GG (eds) Personalised medicine: a new medical and social challenge (Europeanization and globalization). Springer International Publishing, Switzerland, pp 300–320

Peterson DS, Rohr T, Svec F, Fréchet MJ (2002) Enzymatic microreactor-on-a-chip: protein mapping using trypsin immobilized on porous polymer monoliths moulded in channels of microfluidic devices. Anal Chem 74:4081–4088CrossRef

Podgornik A, Barut M, Štrancar A, Josić D, Koloini T (2000) Construction of large-volume monolithic columns. Anal Chem 72:5693–5699CrossRef

Pučić M, Knežević A, Vidič J, Adamczyk B, Novoknet M, Polašek O (2011) High throughput isolation and glycosylation analysis of IgG-variability and heritability of the IgG glycome in three isolated human populations. Mol Cell Proteomics 10:M111.010090CrossRef

Ručević M, Clifton JG, Huang F, Li X, Callanan H, Hixson DC, Josić D (2006) Use of short monolithic columns for isolation of low abundance membrane proteins. J Chromatogr A 1123:199–204CrossRef

Schiel JE, Tong Z, Sakulthaew C, Hage DS (2011) Development of a flow-based ultafast immunoextraction and reverse displacement immunoassay: analysis of free drug fractions. Anal Chem 83:9387–9390CrossRef

Sheng Z-H, Zheng X-Q, Xu J-Y, Bao W-J, Wang F-B, Xia X-H (2012) Electrochemical sensor based on nitrogen doped graphene: simultaneous determination of ascorbic acid, dopamine and uric acid. Biosens Biolectron 34:125–131CrossRef

Shu Q-H, Shi Z-C, Sun Y (2012) Dynamic behavior of binary component ion-exchange displacement chromatography of proteins visualized by confocal laser scanning microscopy. J Chromatogr A 1257:48–57CrossRef

Šrajer Gajdošik M, Clifton J, Josić D (2012) Sample displacement chromatography as a method for purification of proteins and peptides from complex mixtures. J Chromatogr A 1239:1–9CrossRef

Šrajer Gajdošik M, Kovač S, Malatesti N, Müller E, Josić D (2014) Ion-exchange sample displacement chromatography as a method for fast and simple isolation of low- and high-abundance proteins from complex biological mixtures. Food Technol Biotechnol 52:58–63

Štrancar A, Koselj P, Schwinn H, Josić D (1996) Application of compact, porous disks for fast separation of biopolymers and in-process control in biotechnology. Anal Chem 68:3483–3488CrossRef

Svec F, Fréchet JM (1996) New designs of macroporous polymers and supports: from separation to biocatalysis. Science 273:205–211CrossRef

Svec F, Huber F (2006) Monolithic materials: promises, challenges, achievements. Anal Chem 78:2101–2107CrossRef

Švec F, Lv Y (2015) Advances and recent trends in the field of monolithic columns for chromatography. Anal Chem 87:250–273CrossRef

Tennikova TB, Svec F, Belenkii BG (1990) High performance membrane chromatography. A novel method for protein separation. J Liquid Chromatogr 13:63–70CrossRef

The Royal Swedish Academy of Sciences (2002) Advanced Information on the Nobel Prize in Chemistry 2002. www.nobel.se/chemistry/laureates/2002/chemady.pdf

Tiwari A, Turner PF (eds) (2014) Biosensors nanotehnology. Wiley, Scrivene Publishing, USA

Trbojević-Akmačić I, Nemec B, Vidič U, Malić S, Miklić K, Černogoj U, Vidič J, Lendero Kranjc N, Štrancar A, Lauc G, Lenac Roviš T, Pučić-Baković M (2016) Chromatographic monoliths for high-throughput immunoaffinity isolation of transferrin from human plasma. Croat Chem Acta 89:203–211CrossRef

Trusch M, Tillack K, Kwiatkowski M, Bertsch A, Ahrends R, Kohlbacher O, Martin R, Sospedra M, Schlüter H (2012) Displacement chromatography as a first separating step in online two-dimensional chromatography coupled to mass spectrometry analysis of complex protein sample – the proteome of neutrophils. J Chromatogr A 1232:288–294CrossRef

Unger KK (1979) Porous silica: its properties and use in column liquid chromatography. J Chromatogr Library, Elsevier

Vander Heiden MG, Cantley LC, Thompson B (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029–1033CrossRef

Veeraragavan K, Bernier A, Braendli E (1991) Sample displacement mode chromatography: purification of proteins by use of a high-performance anion-exchange column. J Chromatogr A 541:207–220CrossRef

Wang J (2008) Electrochemical glucose biosensors. Chem Rev 108:814–825CrossRef

Wen W, Yan X, Zhu C, Du D, Lin Y (2017) Recent advances in electrochemical immunoassays. Anal Chem 89:138–156CrossRef

Witkowska Nery E, Kundys M, Jeleń PS, Jönsson-Niedziółka M (2016) Electrochemical glucose sensing: is there still room for improvement. Anal Chem 88:11271–11282CrossRef

Wu C, Davey MH, Svec F, Fréchet MJ (2001) Monolithic porous polymer for on-chip solid phase extraction and preconcentration prepared by photoinitiated in situ polymerization within a microfluidic device. Anal Chem 71:5088–5096

Yang Y, Noviana E, Nguyen MP, Geiss BJ, Dandy DS, Henry CS (2017) Paper-based microfluidic devices: emerging themes and applications. Anal Chem 89:71–91CrossRef

Zamperi M, Sekar K, Zamboni N, Sauer U (2017) Frontiers of high-throughput metabolomics. Curr Opin Chem Biol 36:15–23CrossRef

Zang F, Wang X, Ai S, Sun Z, Wan Q, Zhu Z, Xian Y, Jin L, Yamamoto K (2004) Immobilization of uricase on ZnO nanorods for a reagentless uric acid biosensor. Anal Chim Acta 519:155–160CrossRef

Zeng S, Yong K-T, Roy I, Dinh X-Q, Yu X, Luan F (2011) A review on functionalized gold nanoparticles for biosensing applications. Plasmonics 6:491–506CrossRef

Zhong X, Qiao L, Gasilova N, Liu B, Girault HH (2016) Mass barcode signal amplification for multiplex allergy diagnosis by MALDI-MS. Anal Chem 88:6184–6189CrossRef

Title: High-Throughput Analytics in the Function of Personalized Medicine
Authors: Djuro Josić
Tamara Martinović
Urh Černigoj
Jana Vidič
Krešimir Pavelić
Publisher: Springer International Publishing
Book: Personalized Medicine in Healthcare Systems
Print ISBN: 978-3-030-16464-5

Electronic ISBN: 978-3-030-16465-2

Copyright Year: 2019
DOI: https://doi.org/10.1007/978-3-030-16465-2_6