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24-04-2018 | Ceramics

Highly porous 45S5 bioglass-derived glass–ceramic scaffolds by gelcasting of foams

Authors: Lilian de Siqueira, Rubia F. Gouveia, Liliana Grenho, Fernando J. Monteiro, Maria H. Fernandes, Eliandra S. Trichês

Published in: Journal of Materials Science | Issue 15/2018

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Abstract

Several types of alloplastic (artificial) grafts, known as scaffolds, have been developed for the treatment of bone defects caused by trauma and/or infection. Among the materials used to manufacture scaffolds, 45S5 Bioglass is a bioceramic that arouses significant interest due to ease preparation and excellent bioactive response. Among the various processing methods cited in the literature for the production of bioactive glass scaffolds, gelcasting is a method that produces macroporous structures, with interconnected and spherical pores and high mechanical strength. However, in the literature there are few reports about bioactive glass scaffolds produced by gelcasting method. In this work, 45S5-BG scaffolds were produced by gelcasting of foams varying the amount of foaming agent in order to optimize the desirable characteristics of the scaffold. The scaffolds show porosity between 70 and 86% and compressive strength of 1.22 ± 0.7 and 0.78 ± 0.4 MPa. In the biological studies, all 45S5-BG scaffolds showed cytocompatibility towards human osteoblastic cells and bioactive properties using SBF assay.

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Monteiro F, Román JS (2004) Introducción y Desarollo Histórico, 1st edn. Faenza Editrice Ibérica, España, pp 17–26

Ratner B (2004) Biomaterials science: an introduction to materials in medicine, 2nd edn. Academic Press, Cambridge, pp 1–19

Soares G (2005) Biomateriais. In: Fórum de Biotecnologia Biomateriais. UFRJ, Rio de Janeiro, pp 24–28

Holzapfel BM, Reichert JC, Schantz J-T, Gbureck U, Rackwitz L, Nöth U, Jakob F, Rudert M, Groll J, Hutmacher DW (2012) How smart do biomaterials need to be? A translational science and clinical point of view. Adv Drug Deliv Rev 65:581–603. https://doi.org/10.1016/j.addr.2012.07.009 CrossRef

Da Rocha DN, Gobbo LA, Da Silva MHP (2013) Production and characterization of niobate apatite. J Mater Res Technol 2:24–29. https://doi.org/10.1016/j.jmrt.2013.04.007 CrossRef

Hench LL, Wilson J (1993) An introduction to bioceramics, vol 1. Advanced series in ceramic. World Scientific Singapore, Singapore, pp 41–62CrossRef

Hench LL, Splinter RJ, Allen WC, Greenlee TK (1971) Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res 5:117–141. https://doi.org/10.1002/jbm.820050611 CrossRef

Jones JR, Brauer DS, Hupa L, Greenspan DC (2016) Bioglass and bioactive glasses and their impact on healthcare. Int J Appl Glass Sci 7:423–434. https://doi.org/10.1111/ijag.12252 CrossRef

Chen Q-Z, Thouas G (2011) Fabrication and characterization of sol–gel derived 45S5 Bioglass^®–ceramic scaffolds. Acta Biomater 7:3616–3626. https://doi.org/10.1016/j.act.bio.2011.06.005 CrossRef

10.

Chen QZ, Thompson ID, Boccaccini AR (2006) 45S5 Bioglass^®—derived glass–ceramic scaffolds for bone tissue engineering. Biomaterials 27:2414–2425. https://doi.org/10.1016/j.biomaterials.2005.11.025 CrossRef

11.

Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB, Bonewald LF, Tomsia AP (2011) Bioactive glass in tissue engineering. Acta Biomater 7:2355–2373. https://doi.org/10.1016/j.actbio.2011.03.016 CrossRef

12.

Gerhardt L-C, Boccaccini AR (2010) Bioactive glass and glass–ceramic scaffolds for bone tissue engineering. Materials 3:3867–3910. https://doi.org/10.3390/ma3073867 CrossRef

13.

Boccaccini AR, Ma PX (2014) Tissue engineering using ceramics and polymers, 2nd edn. Woodhead Publishing, Cambridge, pp 67–114

14.

Ghomi H, Fathi MH, Edris H (2011) Fabrication and characterization of bioactive glass/hydroxyapatite nanocomposite foam by gelcasting method. Ceram Int 37:1819–1824. https://doi.org/10.1016/j.ceramint.2011.03.002 CrossRef

15.

De Sousa E, Ortega FS, Pandolfelli VC (2009) Produção e caracterização de espumas de alumina pelo processo gelcasting sem controle atmosférico. Cerâmica 55:151–156CrossRef

16.

De Sousa E, Rambo CR, Ortega FS, De Oliveira APN, Pandolfelli VC (2009) Espumas vítreas do sistema Li₂O–ZrO₂–SiO₂–Al₂O₃ produzidas pelo processo gelcasting. Cerâmica 55:157–162CrossRef

17.

Sepulveda P, Binner JG (1999) Processing of cellular ceramics by foaming and in situ polymerisation of organic monomers. J Eur Ceram Soc 19:2059–2066. https://doi.org/10.1016/s0955-2219(99)00024-2 CrossRef

18.

Ortega FS, Valenzuela FAO, Scuracchio CH, Pandolfelli VC (2003) Alternative gelling agents for the gelcasting of ceramic foams. J Eur Ceram Soc 23:75–80. https://doi.org/10.1016/s0955-2219(02)00075-4 CrossRef

19.

Jones JR, Hench L (2003) Regeneration of trabecular bone using porous ceramics. Curr Opin Solid State Mater Sci 7:301–307. https://doi.org/10.1016/j.cossms.2003.09.012 CrossRef

20.

Sepulveda R, Ortega FS, Innocentini MDM, Pandolfelli VC (2000) Properties of highly porous hydroxyapatite obtained by the gelcasting of foams. J Am Ceram Soc 83:3021–3024. https://doi.org/10.1111/j.1151-2916.2000.tb01677.x CrossRef

21.

Sepulveda P, Pandolfelli VC, Rogero SO, Higa OZ, Bressiani JC (1999) Hidroxiapatita porosa produzida através do ‘gelcasting’ de espumas visando aplicações biomédicas. Cerâmica 45:198–202. https://doi.org/10.1590/s0366-6913199000600007 CrossRef

22.

Meng G, Wang H, Zheng W, Liu X (2000) Preparation of porous ceramics by gelcasting approach. Mater. Lett. 45:224–227. https://doi.org/10.1016/s0167-577x(00)00109-9 CrossRef

23.

Wu ZY, Hill RG, Yue S, Nightingale S, Lee PD, Jones JR (2011) Melt-derived bioactive glass scaffolds produced by a gel-cast foaming technique. Acta Biomater 7:1807–1816. https://doi.org/10.1016/j.actbio.2010.11.041 CrossRef

24.

Aguilar-Reyes EA, León-Patiño CA, Jacinto-Diaz B, Lefebvre LP (2012) Structural characterization and mechanical evaluation of bioactive glass 45S5 foams obtained by a powder technology approach. J Am Ceram Soc 95:3776–3780. https://doi.org/10.1111/j.1551-2916.2012.05465.x CrossRef

25.

Nommeots-Nomm A, Labbaf S, Devlin A, Todd N, Geng H, Solanki AK, Tang HM, Perdika P, Pinna A, Ejeian F, Tsigkou O, Lee PD, Esfahani MHN, Mitchell CA, Jones JR (2017) Highly degradable porous melt-derived bioactive glass foam scaffolds for bone regeneration. Acta Biomater 57:449–461. https://doi.org/10.1016/j.actbio.2017.04.030 CrossRef

26.

Elsayed H, Romero AR, Ferroni L, Gardin C, Zavan B, Bernardo E (2017) Bioactive glass–ceramic scaffolds from novel ‘inorganic gel casting’ and sinter crystallization. Materials 10:1–15. https://doi.org/10.3390/ma10020171 CrossRef

27.

Lefebvre L, Chevalier J, Gremillard L, Zenati R, Thollet G, Bernache-Assolant D, Govin A (2007) Structural transformations of bioactive glass 45S5 with thermal treatments. Acta Mater 55:3305–3313. https://doi.org/10.1016/j.actamat.2007.01.029 CrossRef

28.

Kokubo T, Hata K, Nakamura T, Yamamura T (1991) Apatite formation on ceramics, metals, and polymers induced by a CaO–SiO₂-based glass in simulated body fluid. In: Bonfield W, Hastings GW, Tanner KE (eds) Bioceramics, vol 4. Butterworth-Heinemann, London, pp 113–120. ISBN 978-0-7506-0269-3CrossRef

29.

Bellucci D, Cannillo V, Sola A, Chiellini F, Gazzarri M, Migone C (2011) Macroporous Bioglass^®—derived scaffolds for bone tissue regeneration. Ceram Int 37:1575–1585. https://doi.org/10.1016/j.ceramint.2011.01.023 CrossRef

30.

Lopes JH, Magalhaes JA, Gouveia RF, Bertran CA, Motisuke M, Camargo SEA, Triches ES (2016) Hierarchical structures of β-TCP/45S5 bioglass hybrid scaffolds prepared by gelcasting. J Mech Behav Biomed Mater 62:10–23. https://doi.org/10.1016/j.jmbbm.2016.04.028 CrossRef

31.

Gibson LJ, Ashby MF (1999) Cellular solids: structure and properties, 2nd edn. Cambridge University Press, Cambridge, pp 429–452

32.

Bretcanu O, Chatzistavrou X, Paraskevopoulos K, Conradt R, Thompson I, Boccaccini AR (2009) Sintering and crystallisation of 45S5 bioglass^® powder. J Eur Ceram Soc 16:3299–3306. https://doi.org/10.1016/j.jeurceramsoc.2009.06.035 CrossRef

33.

Bellucci D, Sola A, Cannillo V (2011) A revised replication method for bioceramic scaffolds. Bioceram Dev Appl 1:1–8. https://doi.org/10.4303/bda/d110401 CrossRef

34.

Sola A, Bellucci D, Raucci MG, Zeppetelli S, Ambrosio L, Cannillo V (2012) Heat treatment of Na₂O–CaO–P₂O₅–SiO₂ bioactive glasses: densification processes and postsintering bioactivity. J Biomed Mater Res Part A 100:305–322. https://doi.org/10.1002/jbm.a.33276 CrossRef

35.

Farag MM, Rüssel C (2012) Glass–ceramic scaffolds derived from bioglass and glass with low crystallization affinity for bone regeneration. Mater Lett 73:161–165. https://doi.org/10.1016/j.matlet.2011.12.110 CrossRef

36.

Yao Q, Li W, Yu S, Ma L, Jin D, Boccaccini AR (2015) Multifunctional chitosan/polyvinyl pyrrolidone/45S5 Bioglass^® scaffolds for MC3T3-E1 cell stimulation and drug release. Mater Sci Eng C 56:473–480. https://doi.org/10.1016/j.msec.2015.06.046 CrossRef

37.

Motealleh A, Eqtesadi S, Civantos A, Pajares A, Miranda P (2017) Robocast 45S5 bioglass scaffolds: in vitro behavior. J Mater Sci 52:9179–9191. https://doi.org/10.1007/s10853-017-0775-5 CrossRef

38.

Fernandes MH, Gomes PS (2016) Bone cells dynamics during peri-implantitis: a theoretical analysis. JOMR 7:1–19. https://doi.org/10.5037/jomr.2016.7306 CrossRef

39.

Rahaman MN, Xiao W, Fu Q, Huang W (2017) Review—bioactive glass implants for potential application in structural bone repair. Biomed Glasses 3:56–66. https://doi.org/10.1515/bglass-2017-0005 CrossRef

Title: Highly porous 45S5 bioglass-derived glass–ceramic scaffolds by gelcasting of foams
Authors: Lilian de Siqueira
Rubia F. Gouveia
Liliana Grenho
Fernando J. Monteiro
Maria H. Fernandes
Eliandra S. Trichês
Publication date: 24-04-2018
Publisher: Springer US
Published in: Journal of Materials Science / Issue 15/2018
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-018-2337-x

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