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Introduction to Protein Mass Spectrometry Read chapter Read first chapter

2013 | OriginalPaper | Chapter

8. Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization

Authors : Hui Wei, Adrienne A. Tymiak, Guodong Chen

Published in: Characterization of Protein Therapeutics using Mass Spectrometry

Publisher: Springer US

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Abstract

As some of the most essential molecules of life, proteins fulfill a plethora of biochemical functions within every living organism. They are involved in virtually all cell functions, such as cell division, cell death, immune response, signal transduction, and ligand binding. In contrast to small molecules, proteins are significantly more complicated in structure. In biophysical conditions, proteins fold into unique three-dimensional structures in solution that are flexible and dynamic.

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previous chapter Mass Spectrometry of Antibody–Drug Conjugates in Plasma and Tissue in Drug Development
next chapter Fast Photochemical Oxidation of Proteins for Structural Characterization
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Metadata
Title
Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization
Authors
Hui Wei
Adrienne A. Tymiak
Guodong Chen
Copyright Year
2013
Publisher
Springer US
Book
Characterization of Protein Therapeutics using Mass Spectrometry

Print ISBN: 978-1-4419-7861-5

Electronic ISBN: 978-1-4419-7862-2

Copyright Year: 2013

DOI
https://doi.org/10.1007/978-1-4419-7862-2_8

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