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Polymer Bulletin

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19-05-2023 | ORIGINAL PAPER

Hydrophilic matrix system coated by polyvinyl acetate emulsion versus calcium alginate for sustained acetylsalicylic acid release

Authors: Abderrazzaq Essaghraoui, Ahmed Belfkira, Sana Azeroual

Published in: Polymer Bulletin | Issue 3/2024

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Abstract

Maize starch, polyvinyl alcohol, glucose, and magnesium stearate are used as tablet excipients, acetylsalicylic acid as probe, polyvinyl acetate, and calcium alginate as protective membranes. By changing the proportions of the excipients, the nature and the thickness of the protective membrane, it was possible to optimize the formulation of a controlled release tablet. The mechanism and the kinetics of release of the active ingredient are evaluated using kinetic models: zero order, Higuchi, first order, Hixson–Crowell and Krosmeyer–Peppas. The representation of the released quantities using Krosmeyer–Peppas seems to be the most appropriate to describe the release mechanism (R² ~ 1). The k and n values, Krosmeyer–Peppas, indicate that drug release is complex. The release rate of the AI is controlled by the erosion of the membrane and the relaxation of the chains of polymers constituting it. The solubility parameters (δ), according to Hansen, of the hydroxylated ingredients, predict compatibility and stability.

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Efentakis M, Politis S (2006) Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release. Eur Polym J 42:1183–1195CrossRef

Hu Q, Luo Y (2018) Recent advances of polysaccharide-based nanoparticles for oral insulin delivery. Int J Biol Macromol 120:775–782. https://doi.org/10.1016/J.IJBIOMAC.2018.08.152CrossRefPubMed

Araújo F, das Neves J, Martins JP et al (2017) Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals. Prog Mater Sci 89:306–344. https://doi.org/10.1016/J.PMATSCI.2017.05.001CrossRef

Banerjee A, Qi J, Gogoi R et al (2016) Role of nanoparticle size, shape and surface chemistry in oral drug delivery. J Control Release 238:176–185. https://doi.org/10.1016/J.JCONREL.2016.07.051CrossRefPubMedPubMedCentral

Choi HJ, Kim MC, Kang SM, Montemagno CD (2013) The osmotic stress response of split influenza vaccine particles in an acidic environment. Arch Pharmacal Res 3712(37):1607–1616. https://doi.org/10.1007/S12272-013-0257-5CrossRef

Mittal B (2017) Pharmaceutical Unit Operations. How to dev robust solid oral dos forms from concept to post-approval pp. 69–95

Jain S, Jain A, Jain A et al (2016) (2016) Development and evaluation of film coated aceclofenac and chlorzoxazone tablet with enhanced dissolution rate. J Pharm Investig 465(46):467–474. https://doi.org/10.1007/S40005-016-0238-ZCrossRef

Mehta RY, Missaghi S, Tiwari SB, Rajabi-Siahboomi AR (2014) Application of ethylcellulose coating to hydrophilic matrices: a strategy to modulate drug release profile and reduce drug release variability. AAPS PharmSciTech 15:1049–1059. https://doi.org/10.1208/S12249-014-0128-5/TABLES/6CrossRefPubMedPubMedCentral

Yang S, Wang X, Jia J, Li P (2016) Release property study on the novel divalproex sodium enteric-coated capsules. Saudi Pharm J 24:245–249. https://doi.org/10.1016/J.JSPS.2016.04.006CrossRefPubMedPubMedCentral

10.

Lee SH, Bajracharya R, Min JY et al (2020) Strategic approaches for colon targeted drug delivery: an overview of recent advancements. Pharm 12:68. https://doi.org/10.3390/PHARMACEUTICS12010068CrossRef

11.

Seo KS, Bajracharya R, Lee SH, Han HK (2020) Pharmaceutical application of tablet film coating. Pharmaceutics 12:1–20. https://doi.org/10.3390/PHARMACEUTICS12090853CrossRef

12.

Marijnissen WJCM, Van Osch GJVM, Aigner J et al (2002) Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering. Biomaterials 23:1511–1517. https://doi.org/10.1016/S0142-9612(01)00281-2CrossRefPubMed

13.

Park H, Choi B, Hu J, Lee M (2013) Injectable chitosan hyaluronic acid hydrogels for cartilage tissue engineering. Acta Biomater 9:4779–4786. https://doi.org/10.1016/J.ACTBIO.2012.08.033CrossRefPubMed

14.

Freyman TM, Yannas IV, Yokoo R, Gibson LJ (2001) Fibroblast contraction of a collagen-GAG matrix. Biomaterials 22:2883–2891. https://doi.org/10.1016/S0142-9612(01)00034-5CrossRefPubMed

15.

Huang Y, Wang YJ, Wang Y et al (2015) Exploring naturally occurring ivy nanoparticles as an alternative biomaterial. Acta Biomater 25:268–283. https://doi.org/10.1016/J.ACTBIO.2015.07.035CrossRefPubMed

16.

Lenaghan SC, Serpersu K, Xia L et al (2011) A naturally occurring nanomaterial from the Sundew (Drosera) for tissue engineering. Bioinspir Biomim. https://doi.org/10.1088/1748-3182/6/4/046009CrossRefPubMed

17.

de Oliveira Cardoso VM, Stringhetti Ferreira Cury B, Evangelista RC, Daflon Gremião MP (2017) Development and characterization of cross-linked gellan gum and retrograded starch blend hydrogels for drug delivery applications. J Mech Behav Biomed Mater 65:317–333. https://doi.org/10.1016/J.JMBBM.2016.08.005CrossRefPubMed

18.

Ratnayake W, Jackson D (2008) Thermal behavior of resistant starches RS 2, RS 3, and RS 4. J Food Sci 73(5):356–366CrossRef

19.

Sharma A, Yadav B, Ritika (2008) Resistant starch: physiological roles and food applications. Food Rev Int 24: 193–234

20.

Augst A, Kong H, Mooney D (2006) Alginate hydrogels as biomaterials. Macromol Biosci 6:623–633CrossRefPubMed

21.

Lee K, Mooney D (2012) Alginate: properties and biomedical applications. Prog Polym Sci 37:106–126CrossRefPubMedPubMedCentral

22.

Tiwari S, Dinunzio J, Rajabi-Siahboomi A (2011) Drug polymer matrices for extended release. Springer, New York, pp 131–160

23.

Ensslin S, Moll K, Haefele-Racin T, Mäder K (2009) Safety and robustness of coated pellets: self-healing film properties and storage stability. Pharm Res 26:1534–1543. https://doi.org/10.1007/s11095-009-9866-6CrossRefPubMed

24.

Vyskocilova E, Lusticka I, Paterova I et al (2014) Modified MCM-41 as a drug delivery system for acetylsalicylic acid. Solid State Sci 38:85–89CrossRef

25.

HealthCare. ED for the Q of M& (2007) European pharmacopoeia/European Directorate for the Quality of Medicines & HealthCare

26.

Fertah M, Belfkira A, Dahmane E et al (2014) Extraction and characterization of sodium alginate from Moroccan Laminaria digitata brown seaweed. Arab J Chem. https://doi.org/10.1016/j.arabjc.2014.05.003CrossRef

27.

Huggins ML (1942) The viscosity of dilute solutions of long-chain molecules. IV. Dependence on concentration. J Am Chem Soc 64:2716–2718CrossRef

28.

Tanford C (1961) Physical chemistry of macromolecules. Wiley, New York, pp 390–412

29.

Essaghraoui A, Khatib K, Hamdaoui B et al (2021) Handsheet coated by polyvinyl acetate as a drug release system. J Pharm Innov 2021:1–11. https://doi.org/10.1007/S12247-021-09548-3CrossRef

30.

Ritger P, Peppas N (1987) Simple equation for description of solute release II. Fickian and anomalous release from swellable devices. J Control Release 5:37–42CrossRef

31.

Wang N, Sun H, Dong J, Ouyang D (2021) PharmDE: a new expert system for drug-excipient compatibility evaluation. Int J Pharm 607:120962. https://doi.org/10.1016/j.ijpharm.2021.120962CrossRefPubMed

32.

Dave V, Haware R V., Sangave NA, et al (2015) Drug-excipient compatibility studies in formulation development: current trends and techniques

33.

Sin LT, Rahman WAWA, Rahmat AR, Samad AA (2010) Computational modeling and experimental infrared spectroscopy of hydrogen bonding interactions in polyvinyl alcohol–starch blends. Polymer (Guildf) 51:1206–1211. https://doi.org/10.1016/J.POLYMER.2010.01.021CrossRef

34.

Hansen CM (2007) Methods of characterization - surfaces. Hansen Solubility Parameters A Users Handbook, Second Ed 113–123. https://doi.org/10.1201/9781420006834/HANSEN-SOLUBILITY-PARAMETERS-CHARLES-HANSEN

35.

Belfkira A, Montheard J-P (1994) Solubility parameters of poly(4-substituted α-acetoxystyrenes) and alternating copolymers of vinylidene cyanide with substituted styrenes. J Appl Polym Sci 51:1849–1859. https://doi.org/10.1002/APP.1994.070511102CrossRef

36.

Imam SH, Cinelli P, Gordon SH, Chiellini E (2005) Characterization of biodegradable composite films prepared from blends of poly(vinyl alcohol), cornstarch, and lignocellulosic fiber. J Polym Environ 13:47–55. https://doi.org/10.1007/S10924-004-1215-6/METRICSCrossRef

37.

Agnes E, Ortega G (2003) Modelos matemáticos e físico-química da difusão. Cad Farm 19:9–19

38.

Clare K, Algin (1993) In: Whistler RL, BeMiller JN (eds) Industrial Gums, 3^rd edition, Academic Press: New York

39.

Sriamornsak P, Kennedy R (2006) Development of polysaccharide gel coated pellets for oral administration. 2 Calcium alginate. Eur J Pharm Sci 29:139–147CrossRefPubMed

Title: Hydrophilic matrix system coated by polyvinyl acetate emulsion versus calcium alginate for sustained acetylsalicylic acid release
Authors: Abderrazzaq Essaghraoui
Ahmed Belfkira
Sana Azeroual
Publication date: 19-05-2023
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 3/2024
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-023-04861-y

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