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Journal of Nanoparticle Research

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01-11-2020 | Research paper

Impact of palladium nanoparticles (Pd-NPs) on the biology of neutrophils in vitro and on leukocyte attraction in vivo

Authors: Pierrette Kwemo, Abdelaziz Saafane, Marion Vanharen, Isabelle Durocher, Denis Girard

Published in: Journal of Nanoparticle Research | Issue 11/2020

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Abstract

Recently, palladium nanoparticles (Pd-NPs) have been shown to possess pro-inflammatory activities. Herein, we investigated potential in vitro effects of Pd-NPs (primary size of 1–10 nm) on the biology of neutrophils, key player cells in inflammation. Also, the aim of this study was to evaluate the pro-inflammatory activity of Pd-NPs using the murine air pouch model, a model previously proposed to be used as a standard assay for testing in vivo pro-inflammatory effects of NPs. Although the positive controls used in vitro give the expected results in all biological functions tested, Pd-NPs do not affect the production of reactive oxygen species and that of interleukin-1β (IL-1β), IL-6, and IL-8. Pd-NPs moderately increase cellular adhesion of neutrophils onto human endothelial cells and significantly increase the capacity of neutrophils to migrate and to delay apoptosis. We conclude that Pd-NPs possess some pro-inflammatory activity in vitro but do not attract leukocytes in vivo regardless of sex.

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Title: Impact of palladium nanoparticles (Pd-NPs) on the biology of neutrophils in vitro and on leukocyte attraction in vivo
Authors: Pierrette Kwemo
Abdelaziz Saafane
Marion Vanharen
Isabelle Durocher
Denis Girard
Publication date: 01-11-2020
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 11/2020
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-020-05079-z

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