Top

Published in:

2020 | OriginalPaper | Chapter

Impedimetric Aptamer-Based Biosensors: Applications

Authors : John-Alexander Preuß, Peggy Reich, Nicole Bahner, Janina Bahnemann

Published in: Aptamers in Biotechnology

Publisher: Springer International Publishing

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Impedimetric aptamer-based biosensors show high potential for handheld devices and point-of-care tests. In this review, we report on recent advances in aptamer-based impedimetric biosensors for applications in biotechnology. We detail on analytes relevant in medical and environmental biotechnology as well as food control, for which aptamer-based impedimetric biosensors were developed. The reviewed biosensors are examined for their performance, including sensitivity, selectivity, response time, and real sample validation. Additionally, the benefits and challenges of impedimetric aptasensors are summarized.

Graphical Abstract

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

previous chapter Impedimetric Aptamer-Based Biosensors: Principles and Techniques

next chapter Aptamer-Based Affinity Chromatography for Protein Extraction and Purification

Jo H, Kim SK, Youn H, Lee H, Lee K, Jeong J, Mok J, Kim SH, Park HS, Ban C (2016) A highly sensitive and selective impedimetric aptasensor for interleukin-17 receptor A. Biosens Bioelectron 81:80–86. https://doi.org/10.1016/j.bios.2016.02.050CrossRefPubMed

Ocaña C, del Valle M (2014) Signal amplification for thrombin impedimetric aptasensor: sandwich protocol and use of gold-streptavidin nanoparticles. Biosens Bioelectron 54:408–414. https://doi.org/10.1016/j.bios.2013.10.068CrossRefPubMed

Qi H, Shangguan L, Li C, Li X, Gao Q, Zhang C (2013) Sensitive and antifouling impedimetric aptasensor for the determination of thrombin in undiluted serum sample. Biosens Bioelectron 39(1):324–328. https://doi.org/10.1016/j.bios.2012.07.040CrossRefPubMed

Snyderman R (2012) Personalized health care: from theory to practice. Biotechnol J 7(8):973–979. https://doi.org/10.1002/biot.201100297CrossRefPubMed

Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC, Taubert K, Tracy RP, Vinicor F (2003) Markers of inflammation and cardiovascular disease application to clinical and public health practice – a statement for healthcare professionals from the centers for disease control and prevention and the American Heart Association. Circulation 107(3):499–511. https://doi.org/10.1161/01.Cir.0000052939.59093.45CrossRefPubMed

Qureshi A, Gurbuz Y, Kallempudi S, Niazi JH (2010) Label-free RNA aptamer-based capacitive biosensor for the detection of C-reactive protein. Phys Chem Chem Phys 12(32):9176–9182. https://doi.org/10.1039/c004133eCrossRefPubMed

Piccoli J, Hein R, El-Sagheer AH, Brown T, Cilli EM, Bueno PR, Davis JJ (2018) Redox capacitive assaying of C-reactive protein at a peptide supported aptamer interface. Anal Chem 90(5):3005–3008. https://doi.org/10.1021/acs.analchem.7b05374CrossRefPubMed

Aray A, Chiavaioli F, Arjmand M, Trono C, Tombelli S, Giannetti A, Cennamo N, Soltanolkotabi M, Zeni L, Baldini F (2016) SPR-based plastic optical fibre biosensor for the detection of C-reactive protein in serum. J Biophotonics 9(10):1077–1084. https://doi.org/10.1002/jbio.201500315CrossRefPubMed

Bryan T, Luo XL, Bueno PR, Davis JJ (2013) An optimised electrochemical biosensor for the label-free detection of C-reactive protein in blood. Biosens Bioelectron 39(1):94–98. https://doi.org/10.1016/j.bios.2012.06.051CrossRefPubMed

10.

Bing X, Wang G (2017) Label free C-reactive protein detection based on an electrochemical sensor for clinical application. Int J Electrochem Sci 12(7):6304–6314CrossRef

11.

Wu B, Jiang R, Wang Q, Huang J, Yang XH, Wang KM, Li WS, Chen ND, Li Q (2016) Detection of C-reactive protein using nanoparticle- enhanced surface plasmon resonance using an aptamer-antibody sandwich assay. Chem Commun 52(17):3568–3571. https://doi.org/10.1039/c5cc10486fCrossRef

12.

Zubiate P, Zamarreno CR, Sanchez R, Matias IR, Arregui FJ (2017) High sensitive and selective C-reactive protein detection by means of lossy mode resonance based optical fiber devices. Biosens Bioelectron 93:176–181. https://doi.org/10.1016/j.bios.2016.09.020CrossRefPubMed

13.

Vasilescu A, Wang Q, Li MS, Boukherroub R, Szunerits S (2016) Aptamer-based electrochemical sensing of lysozyme. Chemosensors 4(2):20. https://doi.org/10.3390/chemosensors4020010CrossRef

14.

Peng Y, Zhang D, Li Y, Qi H, Gao Q, Zhang C (2009) Label-free and sensitive faradic impedance aptasensor for the determination of lysozyme based on target-induced aptamer displacement. Biosens Bioelectron 25(1):94–99. https://doi.org/10.1016/j.bios.2009.06.001CrossRefPubMed

15.

Xia Y, Gan S, Xu Q, Qiu X, Gao P, Huang S (2013) A three-way junction aptasensor for lysozyme detection. Biosens Bioelectron 39(1):250–254. https://doi.org/10.1016/j.bios.2012.07.053CrossRefPubMed

16.

Zhang Z, Zhang S, He L, Peng D, Yan F, Wang M, Zhao J, Zhang H, Fang S (2015) Feasible electrochemical biosensor based on plasma polymerization-assisted composite of polyacrylic acid and hollow TiO₂ spheres for sensitively detecting lysozyme. Biosens Bioelectron 74:384–390. https://doi.org/10.1016/j.bios.2015.06.062

17.

Chen ZB, Li LD, Zhao HT, Guo L, Mu XJ (2011) Electrochemical impedance spectroscopy detection of lysozyme based on electrodeposited gold nanoparticles. Talanta 83(5):1501–1506. https://doi.org/10.1016/j.talanta.2010.11.042CrossRefPubMed

18.

Khan NI, Maddaus AG, Song E (2018) A low-cost inkjet-printed aptamer-based electrochemical biosensor for the selective detection of lysozyme. Biosensors 8(1):7. https://doi.org/10.3390/bios8010007CrossRefPubMedCentral

19.

Dong YP, Wang J, Peng Y, Zhu JJ (2017) A novel aptasensor for lysozyme based on electrogenerated chemiluminescence resonance energy transfer between luminol and silicon quantum dots. Biosens Bioelectron 94:530–535. https://doi.org/10.1016/j.bios.2017.03.044CrossRefPubMed

20.

Krenzlin H, Lorenz V, Danckwardt S, Kempski O, Alessandri B (2016) The importance of thrombin in cerebral injury and disease. Int J Mol Sci 17(1):84. https://doi.org/10.3390/ijms17010084CrossRefPubMedCentral

21.

Deng CY, Chen JH, Nie LH, Nie Z, Yao SZ (2009) Sensitive bifunctional aptamer-based electrochemical biosensor for small molecules and protein. Anal Chem 81(24):9972–9978. https://doi.org/10.1021/ac901727zCrossRefPubMed

22.

Lu L, Li J, Kang T, Cheng S (2015) Bi-functionalized aptasensor for ultrasensitive detection of thrombin. Talanta 138:273–278. https://doi.org/10.1016/j.talanta.2015.03.016CrossRefPubMed

23.

Heydari-Bafrooei E, Amini M, Ardakani MH (2016) An electrochemical aptasensor based on TiO₂/MWCNT and a novel synthesized Schiff base nanocomposite for the ultrasensitive detection of thrombin. Biosens Bioelectron 85:828–836. https://doi.org/10.1016/j.bios.2016.06.012

24.

Gaffen SL (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 9(8):556–567. https://doi.org/10.1038/nri2586CrossRefPubMedPubMedCentral

25.

Tertiş M, Ciui B, Suciu M, Săndulescu R, Cristea C (2017) Label-free electrochemical aptasensor based on gold and polypyrrole nanoparticles for interleukin 6 detection. Electrochim Acta 258:1208–1218. https://doi.org/10.1016/j.electacta.2017.11.176CrossRef

26.

Jo H, Gu H, Jeon W, Youn H, Her J, Kim SK, Lee J, Shin JH, Ban C (2015) Electrochemical Aptasensor of cardiac troponin I for the early diagnosis of acute myocardial infarction. Anal Chem 87(19):9869–9875. https://doi.org/10.1021/acs.analchem.5b02312CrossRefPubMed

27.

Boriani G, Biffi M, Cervi V, Bronzetti G, Magagnoli G, Zannoli R, Branzi A (2000) Evaluation of myocardial injury following repeated internal atrial shocks by monitoring serum cardiac troponin I levels. Chest 118(2):342–347. https://doi.org/10.1378/chest.118.2.342CrossRefPubMed

28.

Wang B, Jing R, Qi HL, Gao Q, Zhang CX (2016) Label-free electrochemical impedance peptide-based biosensor for the detection of cardiac troponin I incorporating gold nanoparticles modified carbon electrode. J Electroanal Chem 781:212–217. https://doi.org/10.1016/j.jelechem.2016.08.005CrossRef

29.

Akter R, Jeong B, Lee YM, Choi JS, Rahman MA (2017) Femtomolar detection of cardiac troponin I using a novel label-free and reagent-free dendrimer enhanced impedimetric immunosensor. Biosens Bioelectron 91:637–643. https://doi.org/10.1016/j.bios.2017.01.021CrossRefPubMed

30.

Jorgensen P, Chanthap L, Rebueno A, Tsuyuoka R, Bell D (2006) Malaria rapid diagnostic tests in tropical climates: the need for a cool chain. Am J Trop Med Hyg 74(5):750–754. https://doi.org/10.4269/ajtmh.2006.74.750CrossRefPubMed

31.

Lee S, Song KM, Jeon W, Jo H, Shim YB, Ban C (2012) A highly sensitive aptasensor towards plasmodium lactate dehydrogenase for the diagnosis of malaria. Biosens Bioelectron 35(1):291–296. https://doi.org/10.1016/j.bios.2012.03.003CrossRefPubMed

32.

Figueroa-Miranda G, Feng L, Shiu SC-C, Dirkzwager RM, Cheung Y-W, Tanner JA, Schöning MJ, Offenhäusser A, Mayer D (2018) Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability. Sensors Actuators B Chem 255:235–243. https://doi.org/10.1016/j.snb.2017.07.117CrossRef

33.

Kiilerich-Pedersen K, Daprà J, Cherré S, Rozlosnik N (2013) High sensitivity point-of-care device for direct virus diagnostics. Biosens Bioelectron 49:374–379. https://doi.org/10.1016/j.bios.2013.05.046CrossRefPubMed

34.

Otero C, Penaloza JP, Rodas PI, Fernandez-Ramires R, Velasquez L, Jung JE (2014) Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases. Fundam Clin Pharmacol 28(6):593–607. https://doi.org/10.1111/fcp.12080CrossRefPubMed

35.

Zhao F, Xie Q, Xu M, Wang S, Zhou J, Liu F (2015) RNA aptamer based electrochemical biosensor for sensitive and selective detection of cAMP. Biosens Bioelectron 66:238–243. https://doi.org/10.1016/j.bios.2014.11.024CrossRefPubMed

36.

Wang Y, Feng J, Tan Z, Wang H (2014) Electrochemical impedance spectroscopy aptasensor for ultrasensitive detection of adenosine with dual backfillers. Biosens Bioelectron 60:218–223. https://doi.org/10.1016/j.bios.2014.04.022CrossRefPubMed

37.

Feng L, Chen Y, Ren J, Qu X (2011) A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cells. Biomaterials 32(11):2930–2937. https://doi.org/10.1016/j.biomaterials.2011.01.002CrossRefPubMed

38.

Kashefi-Kheyrabadi L, Mehrgardi MA, Wiechec E, Turner AP, Tiwari A (2014) Ultrasensitive detection of human liver hepatocellular carcinoma cells using a label-free aptasensor. Anal Chem 86(10):4956–4960. https://doi.org/10.1021/ac500375pCrossRefPubMed

39.

Hashkavayi AB, Raoof JB, Ojani R, Kavoosian S (2017) Ultrasensitive electrochemical aptasensor based on sandwich architecture for selective label-free detection of colorectal cancer (CT26) cells. Biosens Bioelectron 92:630–637. https://doi.org/10.1016/j.bios.2016.10.042CrossRefPubMed

40.

Shen H, Yang J, Chen Z, Chen X, Wang L, Hu J, Ji F, Xie G, Feng W (2016) A novel label-free and reusable electrochemical cytosensor for highly sensitive detection and specific collection of CTCs. Biosens Bioelectron 81:495–502. https://doi.org/10.1016/j.bios.2016.03.048CrossRefPubMed

41.

Tsuchiya N, Sawada Y, Endo I, Saito K, Uemura Y, Nakatsura T (2015) Biomarkers for the early diagnosis of hepatocellular carcinoma. World J Gastroenterol 21(37):10573–10583. https://doi.org/10.3748/wjg.v21.i37.10573CrossRefPubMedPubMedCentral

42.

Laboria N, Fragoso A, Kemmner W, Latta D, Nilsson O, Botero ML, Drese K, O’Sullivan CK (2010) Amperometric immunosensor for carcinoembryonic antigen in colon cancer samples based on monolayers of dendritic bipodal scaffolds. Anal Chem 82(5):1712–1719. https://doi.org/10.1021/ac902162eCrossRefPubMed

43.

Shekari Z, Zare HR, Falahati A (2017) Developing an impedimetric aptasensor for selective label–free detection of CEA as a cancer biomarker based on gold nanoparticles loaded in functionalized mesoporous silica films. J Electrochem Soc 164(13):B739–B745. https://doi.org/10.1149/2.1991713jesCrossRef

44.

Wang W, Ge L, Sun X, Hou T, Li F (2015) Graphene-assisted label-free homogeneous electrochemical biosensing strategy based on aptamer-switched bidirectional DNA polymerization. ACS Appl Mater Interfaces 7(51):28566–28575. https://doi.org/10.1021/acsami.5b09932CrossRefPubMed

45.

Guo C, Su F, Song Y, Hu B, Wang M, He L, Peng D, Zhang Z (2017) Aptamer-templated silver nanoclusters embedded in zirconium metal-organic framework for bifunctional electrochemical and SPR aptasensors toward carcinoembryonic antigen. ACS Appl Mater Interfaces 9(47):41188–41199. https://doi.org/10.1021/acsami.7b14952CrossRefPubMed

46.

Wang K, He MQ, Zhai FH, He RH, Yu YL (2017) A novel electrochemical biosensor based on polyadenine modified aptamer for label-free and ultrasensitive detection of human breast cancer cells. Talanta 166:87–92. https://doi.org/10.1016/j.talanta.2017.01.052CrossRefPubMed

47.

Zhou F, Yuan L, Wang H, Li D, Chen H (2011) Gold nanoparticle layer: a promising platform for ultra-sensitive cancer detection. Langmuir 27:2155–2158. https://doi.org/10.1021/la1049937CrossRefPubMed

48.

Qureshi A, Gurbuz Y, Niazi JH (2015) Capacitive aptamer–antibody based sandwich assay for the detection of VEGF cancer biomarker in serum. Sensors Actuators B Chem 209:645–651. https://doi.org/10.1016/j.snb.2014.12.040CrossRef

49.

Tabrizi MA, Shamsipur M, Farzin L (2015) A high sensitive electrochemical aptasensor for the determination of VEGF(165) in serum of lung cancer patient. Biosens Bioelectron 74:764–769. https://doi.org/10.1016/j.bios.2015.07.032CrossRef

50.

Salven P, Perhoniemi V, Tykkä H, Mäenpää H, Joensuu H (1999) Serum VEGF levels in women with a benign breast tumor or breast cancer. Breast Cancer Res Treat 53(2):161–166CrossRef

51.

Liu C, Liu X, Qin Y, Deng C, Xiang J (2016) A simple regenerable electrochemical aptasensor for the parallel and continuous detection of biomarkers. RSC Adv 6(63):58469–58476. https://doi.org/10.1039/C6RA09284ECrossRef

52.

Teke M, Sayikli C, Canbaz C, Sezgintürk MK (2014) A novel biosensing system using biological receptor for analysis of vascular endothelial growth factor. Int J Pept Res Ther 20(2):221–230. https://doi.org/10.1007/s10989-013-9386-4CrossRef

53.

Pan LH, Kuo SH, Lin TY, Lin CW, Fang PY, Yang HW (2017) An electrochemical biosensor to simultaneously detect VEGF and PSA for early prostate cancer diagnosis based on graphene oxide/ssDNA/PLLA nanoparticles. Biosens Bioelectron 89:598–605. https://doi.org/10.1016/j.bios.2016.01.077CrossRefPubMed

54.

Da HM, Liu HY, Zheng YN, Yuan R, Chai YQ (2018) A highly sensitive VEGF(165) photoelectrochemical biosensor fabricated by assembly of aptamer bridged DNA networks. Biosens Bioelectron 101:213–218. https://doi.org/10.1016/j.bios.2017.10.032CrossRefPubMed

55.

Achard C, Surendran A, Wedge ME, Ungerechts G, Bell J, Ilkow CS (2018) Lighting a fire in the tumor microenvironment using oncolytic immunotherapy. EBioMedicine 31:17–24. https://doi.org/10.1016/j.ebiom.2018.04.020CrossRefPubMedPubMedCentral

56.

Labib M, Zamay AS, Muharemagic D, Chechik A, Bell JC, Berezovski MV (2012) Electrochemical sensing of aptamer-facilitated virus immunoshielding. Anal Chem 84(3):1677–1686. https://doi.org/10.1021/ac202978rCrossRefPubMed

57.

Scudder J, Ye JY (2018) Limulus amoebocyte lysate test via an open-microcavity optical biosensor. J Biomed Opt 23(2):6. https://doi.org/10.1117/1.Jbo.23.2.027001CrossRef

58.

Su W, Kim SE, Cho M, Nam JD, Choe WS, Lee Y (2013) Selective detection of endotoxin using an impedance aptasensor with electrochemically deposited gold nanoparticles. Innate Immun 19(4):388–397. https://doi.org/10.1177/1753425912465099CrossRefPubMed

59.

Posha B, Nambiar SR, Sandhyarani N (2018) Gold atomic cluster mediated electrochemical aptasensor for the detection of lipopolysaccharide. Biosens Bioelectron 101:199–205. https://doi.org/10.1016/j.bios.2017.10.030CrossRefPubMed

60.

Kim SE, Su W, Cho M, Lee Y, Choe WS (2012) Harnessing aptamers for electrochemical detection of endotoxin. Anal Biochem 424(1):12–20. https://doi.org/10.1016/j.ab.2012.02.016CrossRefPubMed

61.

Zandieh M, Hosseini SN, Vossoughi M, Khatami M, Abbasian S, Moshaii A (2018) Label-free and simple detection of endotoxins using a sensitive LSPR biosensor based on silver nanocolumns. Anal Biochem 548:96–101. https://doi.org/10.1016/j.ab.2018.02.023CrossRefPubMed

62.

Walter JG, Heilkenbrinker A, Austerjost J, Timur S, Stahl F, Scheper T (2012) Aptasensors for small molecule detection. ZNaturforsch(B) 67(10):976–986. https://doi.org/10.5560/znb.2012-0147CrossRef

63.

Roushani M, Shahdost-Fard F (2018) Impedimetric detection of cocaine by using an aptamer attached to a screen printed electrode modified with a dendrimer/silver nanoparticle nanocomposite. Microchim Acta 185(4):8. https://doi.org/10.1007/s00604-018-2709-6CrossRef

64.

Roushani M, Shandost-fard F (2017) Ultra-sensitive detection of ibuprofen (IBP) by electrochemical aptasensor using the dendrimer-quantum dot (Den-QD) bioconjugate as an immobilization platform with special features. Mater Sci Eng C Mater Biol Appl 75:1091–1096. https://doi.org/10.1016/j.msec.2017.03.023CrossRefPubMed

65.

Alsirawan MB, Mohammad M, Al-kasmi B, Alhareth K, El-Hammadi M (2013) Development and validation of a simple HPLC method for the determination of ibuprofen sticking onto punch faces. Int J Pharm Pharm Sci 5(Suppl 4):227–231

66.

Stephenson JB, Flater ML, Bain LT (2016) Analysis of Valproic acid, salicylic acid and ibuprofen in whole blood by GC-MS. J Anal Toxicol 40(8):649–652. https://doi.org/10.1093/jat/bkw079CrossRefPubMed

67.

Liang G, Man Y, Jin X, Pan L, Liu X (2016) Aptamer-based biosensor for label-free detection of ethanolamine by electrochemical impedance spectroscopy. Anal Chim Acta 936:222–228. https://doi.org/10.1016/j.aca.2016.06.056CrossRefPubMed

68.

Pilehvar S, Dierckx T, Blust R, Breugelmans T, De Wael K (2014) An electrochemical impedimetric aptasensing platform for sensitive and selective detection of small molecules such as chloramphenicol. Sensors 14(7):12059–12069. https://doi.org/10.3390/s140712059CrossRefPubMed

69.

Bahner N, Reich P, Frense D, Menger M, Schieke K, Beckmann D (2018) An aptamer-based biosensor for detection of doxorubicin by electrochemical impedance spectroscopy. Anal Bioanal Chem 410(5):1453–1462. https://doi.org/10.1007/s00216-017-0786-8CrossRefPubMed

70.

Erdem A, Karadeniz H, Caliskan A (2011) Dendrimer modified graphite sensors for detection of anticancer drug Daunorubicin by voltammetry and electrochemical impedance spectroscopy. Analyst 136(5):1041–1045. https://doi.org/10.1039/c0an00357cCrossRefPubMed

71.

Zhu B, Alsager OA, Kumar S, Hodgkiss JM, Travas-Sejdic J (2015) Label-free electrochemical aptasensor for femtomolar detection of 17beta-estradiol. Biosens Bioelectron 70:398–403. https://doi.org/10.1016/j.bios.2015.03.050CrossRefPubMed

72.

Lin Z, Chen L, Zhang G, Liu Q, Qiu B, Cai Z, Chen G (2012) Label-free aptamer-based electrochemical impedance biosensor for 17beta-estradiol. Analyst 137(4):819–822. https://doi.org/10.1039/c1an15856bCrossRefPubMed

73.

Contreras Jiménez G, Eissa S, Ng A, Alhadrami H, Zourob M, Siaj M (2015) Aptamer-based label-free impedimetric biosensor for detection of progesterone. Anal Chem 87(2):1075–1082. https://doi.org/10.1021/ac503639sCrossRefPubMed

74.

Commission Regulation (EC) No 181/2003 (2003) 2003/181/EC: commission decision of 13 March 2003 amending decision 2002/657/EC as regards the setting of minimum required performance limits (MRPLs) for certain residues in food of animal origin

75.

Brosel-Oliu S, Ferreira R, Uria N, Abramova N, Gargallo R, Muñoz-Pascual F-X, Bratov A (2018) Novel impedimetric aptasensor for label-free detection of Escherichia coli O157:H7. Sensors Actuators B Chem 255:2988–2995. https://doi.org/10.1016/j.snb.2017.09.121CrossRef

76.

Eissa S, Siaj M, Zourob M (2015) Aptamer-based competitive electrochemical biosensor for brevetoxin-2. Biosens Bioelectron 69:148–154. https://doi.org/10.1016/j.bios.2015.01.055CrossRefPubMed

77.

Zhao Z, Chen H, Ma L, Liu D, Wang Z (2015) A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites. Analyst 140(16):5570–5577. https://doi.org/10.1039/c5an00704fCrossRefPubMed

78.

Lin Z, Huang H, Xu Y, Gao X, Qiu B, Chen X, Chen G (2013) Determination of microcystin-LR in water by a label-free aptamer based electrochemical impedance biosensor. Talanta 103:371–374. https://doi.org/10.1016/j.talanta.2012.10.081CrossRefPubMed

79.

Madianos L, Tsekenis G, Skotadis E, Patsiouras L, Tsoukalas D (2018) A highly sensitive impedimetric aptasensor for the selective detection of acetamiprid and atrazine based on microwires formed by platinum nanoparticles. Biosens Bioelectron 101:268–274. https://doi.org/10.1016/j.bios.2017.10.034CrossRefPubMed

80.

Azadbakht A, Roushani M, Abbasi AR, Derikvand Z (2016) A novel impedimetric aptasensor, based on functionalized carbon nanotubes and prussian blue as labels. Anal Biochem 512:58–69. https://doi.org/10.1016/j.ab.2016.08.006CrossRefPubMed

81.

Kazane I, Gorgy K, Gondran C, Spinelli N, Zazoua A, Defrancq E, Cosnier S (2016) Highly sensitive bisphenol-A electrochemical aptasensor based on poly(Pyrrole-Nitrilotriacetic acid)-aptamer film. Anal Chem 88(14):7268–7273. https://doi.org/10.1021/acs.analchem.6b01574CrossRefPubMed

82.

Ma Y, Liu J, Li H (2017) Diamond-based electrochemical aptasensor realizing a femtomolar detection limit of bisphenol A. Biosens Bioelectron 92:21–25. https://doi.org/10.1016/j.bios.2017.01.041CrossRefPubMed

83.

Flewelling LJ, Naar JP, Abbott JP, Baden DG, Barros NB, Bossart GD, Bottein M-YD, Hammond DG, Haubold EM, Heil CA, Henry MS, Jacocks HM, Leighfield TA, Pierce RH, Pitchford TD, Rommel SA, Scott PS, Steidinger KA, Truby EW, Van Dolah FM, Landsberg JH (2005) Red tides and marine mammal mortalities. Nature 435:755. https://doi.org/10.1038/nature435755aCrossRefPubMedPubMedCentral

84.

Tang D, Tang J, Su B, Chen G (2011) Gold nanoparticles-decorated amine-terminated poly(amidoamine) dendrimer for sensitive electrochemical immunoassay of brevetoxins in food samples. Biosens Bioelectron 26(5):2090–2096. https://doi.org/10.1016/j.bios.2010.09.012CrossRefPubMed

85.

Bazin E, Huet S, Jarry G, Hégarat LL, Munday JS, Humpage AR, Fessard V (2012) Cytotoxic and genotoxic effects of cylindrospermopsin in mice treated by gavage or intraperitoneal injection. Environ Toxicol 27(5):277–284. https://doi.org/10.1002/tox.20640CrossRefPubMed

86.

Eaglesham GK, Norris RL, Shaw GR, Smith MJ, Chiswell RK, Davis BC, Neville GR, Seawright AA, Moore MR (1999) Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue–green algal toxin, for public health purposes. Environ Toxicol 14(1):151–154. https://doi.org/10.1002/(SICI)1522-7278(199902)14:1<151::AID-TOX19>3.0.CO;2-DCrossRef

87.

Guzmán-Guillén R, Prieto AI, González AG, Soria-Díaz ME, Cameán AM (2012) Cylindrospermopsin determination in water by LC-MS/MS: optimization and validation of the method and application to real samples. Environ Toxicol Chem 31(10):2233–2238. https://doi.org/10.1002/etc.1954CrossRefPubMed

88.

Seccia S, Fidente P, Barbini DA, Morrica P (2005) Multiresidue determination of nicotinoid insecticide residues in drinking water by liquid chromatography with electrospray ionization mass spectrometry. Anal Chim Acta 553(1):21–26. https://doi.org/10.1016/j.aca.2005.08.006CrossRef

89.

Verdian A (2018) Apta-nanosensors for detection and quantitative determination of acetamiprid – A pesticide residue in food and environment. Talanta 176:456–464. https://doi.org/10.1016/j.talanta.2017.08.070CrossRefPubMed

90.

Tanner G, Czerwenka C (2011) LC-MS/MS analysis of neonicotinoid insecticides in honey: methodology and residue findings in Austrian honeys. J Agric Food Chem 59(23):12271–12277. https://doi.org/10.1021/jf202775mCrossRefPubMed

91.

Dujaković N, Grujić S, Radišić M, Vasiljević T, Laušević M (2010) Determination of pesticides in surface and ground waters by liquid chromatography–electrospray–tandem mass spectrometry. Anal Chim Acta 678(1):63–72. https://doi.org/10.1016/j.aca.2010.08.016CrossRefPubMed

92.

Zhang B, Pan X, Venne L, Dunnum S, McMurry ST, Cobb GP, Anderson TA (2008) Development of a method for the determination of 9 currently used cotton pesticides by gas chromatography with electron capture detection. Talanta 75(4):1055–1060. https://doi.org/10.1016/j.talanta.2008.01.032CrossRefPubMed

93.

Mateu-Sánchez M, Moreno M, Arrebola FJ, Martínez Vidal JL (2003) Analysis of acetamiprid in vegetables using gas chromatography-tandem mass spectrometry. Anal Sci 19(5):701–704. https://doi.org/10.2116/analsci.19.701CrossRefPubMed

94.

Wanatabe S, Ito S, Kamata Y, Omoda N, Yamazaki T, Munakata H, Kaneko T, Yuasa Y (2001) Development of competitive enzyme-linked immunosorbent assays (ELISAs) based on monoclonal antibodies for chloronicotinoid insecticides imidacloprid and acetamiprid. Anal Chim Acta 427(2):211–219. https://doi.org/10.1016/S0003-2670(00)01126-0CrossRef

95.

Fan L, Zhao G, Shi H, Liu M, Li Z (2013) A highly selective electrochemical impedance spectroscopy-based aptasensor for sensitive detection of acetamiprid. Biosens Bioelectron 43:12–18. https://doi.org/10.1016/j.bios.2012.11.033CrossRefPubMed

96.

Fei A, Liu Q, Huan J, Qian J, Dong X, Qiu B, Mao H, Wang K (2015) Label-free impedimetric aptasensor for detection of femtomole level acetamiprid using gold nanoparticles decorated multiwalled carbon nanotube-reduced graphene oxide nanoribbon composites. Biosens Bioelectron 70:122–129. https://doi.org/10.1016/j.bios.2015.03.028CrossRefPubMed

97.

Jiang D, Du X, Liu Q, Zhou L, Dai L, Qian J, Wang K (2015) Silver nanoparticles anchored on nitrogen-doped graphene as a novel electrochemical biosensing platform with enhanced sensitivity for aptamer-based pesticide assay. Analyst 140(18):6404–6411. https://doi.org/10.1039/c5an01084eCrossRefPubMed

98.

Wang W, Yang X, Gu Y-X, Ding C-F, Wan J (2015) Preparation and properties of bisphenol A sensor based on multiwalled carbon nanotubes/Li₄Ti₅O₁₂-modified electrode. Ionics 21(3):885–893. https://doi.org/10.1007/s11581-014-1217-x

99.

Commission Regulation (EU) No 10/2011 (2011) Commission Regulation (EU) No 10/2011 of 14 January 2011 on plastic materials and articles intended to come into contact with food

100.

Ghoshal G (2018) Chapter 2 – biotechnology in food processing and preservation: an overview. In: Holban AM, Grumezescu AM (eds) Advances in biotechnology for food industry. Academic Press, Cambridge, pp 27–54. https://doi.org/10.1016/B978-0-12-811443-8.00002-5CrossRef

101.

Kuchenmüller T, Hird S, Stein C, Kramarz P, Nanda A, Havelaar AH (2009) Estimating the global burden of foodborne diseases – a collaborative effort. Eur Secur 14(18):19195. https://doi.org/10.2807/ese.14.18.19195-enCrossRef

102.

Frisvad JC, Thrane U, Samson RA, Pitt JI (2006) Important mycotoxins and the fungi which produce them. In: Advances in food mycology. Springer, Boston, pp 3–31CrossRef

103.

Vidal JC, Bonel L, Ezquerra A, Hernández S, Bertolín JR, Cubel C, Castillo JR (2013) Electrochemical affinity biosensors for detection of mycotoxins: a review. Biosens Bioelectron 49:146–158. https://doi.org/10.1016/j.bios.2013.05.008CrossRefPubMed

104.

Prabhakar N, Matharu Z, Malhotra BD (2011) Polyaniline Langmuir-Blodgett film based aptasensor for ochratoxin A detection. Biosens Bioelectron 26(10):4006–4011. https://doi.org/10.1016/j.bios.2011.03.014CrossRefPubMed

105.

Castillo G, Lamberti I, Mosiello L, Hianik T (2012) Impedimetric DNA Aptasensor for sensitive detection of Ochratoxin A in food. Electroanalysis 24(3):512–520. https://doi.org/10.1002/elan.201100485CrossRef

106.

Evtugyn G, Porfireva A, Sitdikov R, Evtugyn V, Stoikov I, Antipin I, Hianik T (2013) Electrochemical APTASENSOR for the determination of Ochratoxin A at the Au electrode modified with Ag nanoparticles decorated with macrocyclic ligand. Electroanalysis 25(8):1847–1854. https://doi.org/10.1002/elan.201300164CrossRef

107.

Hayat A, Sassolas A, Marty JL, Radi AE (2013) Highly sensitive ochratoxin A impedimetric aptasensor based on the immobilization of azido-aptamer onto electrografted binary film via click chemistry. Talanta 103:14–19. https://doi.org/10.1016/j.talanta.2012.09.048CrossRefPubMed

108.

Rivas L, Mayorga-Martinez CC, Quesada-González D, Zamora-Gálvez A, de la Escosura-Muñiz A, Merkoçi A (2015) Label-free impedimetric aptasensor for ochratoxin-A detection using iridium oxide nanoparticles. Anal Chem 87(10):5167–5172. https://doi.org/10.1021/acs.analchem.5b00890CrossRefPubMed

109.

Mejri-Omrani N, Miodek A, Zribi B, Marrakchi M, Hamdi M, Marty JL, Korri-Youssoufi H (2016) Direct detection of OTA by impedimetric aptasensor based on modified polypyrrole-dendrimers. Anal Chim Acta 920:37–46. https://doi.org/10.1016/j.aca.2016.03.038CrossRefPubMed

110.

Wei M, Zhang W (2017) A novel impedimetric aptasensor based on AuNPs–carboxylic porous carbon for the ultrasensitive detection of ochratoxin A. RSC Adv 7(46):28655–28660. https://doi.org/10.1039/c7ra04209dCrossRef

111.

Simão EP, Cao-Milán R, Costa-Pedro G, De Melo CP, Cao R, Oliveira MDL, Andrade CAS (2017) Simple and fast picomolar detection of ochratoxin A using a reusable label free aptasensor built with a layer-by-layer procedure. Electroanalysis 29(10):2268–2275. https://doi.org/10.1002/elan.201700290CrossRef

112.

Castillo G, Spinella K, Poturnayová A, Šnejdárková M, Mosiello L, Hianik T (2015) Detection of aflatoxin B 1 by aptamer-based biosensor using PAMAM dendrimers as immobilization platform. Food Control 52:9–18. https://doi.org/10.1016/j.foodcont.2014.12.008CrossRef

113.

Li Q, Lu Z, Tan X, Xiao X, Wang P, Wu L, Shao K, Yin W, Han H (2017) Ultrasensitive detection of aflatoxin B1 by SERS aptasensor based on exonuclease-assisted recycling amplification. Biosens Bioelectron 97:59–64. https://doi.org/10.1016/j.bios.2017.05.031CrossRefPubMed

114.

Istamboulié G, Paniel N, Zara L, Reguillo Granados L, Barthelmebs L, Noguer T (2016) Development of an impedimetric aptasensor for the determination of aflatoxin M1 in milk. Talanta 146:464–469. https://doi.org/10.1016/j.talanta.2015.09.012CrossRefPubMed

115.

Chen X, Huang Y, Ma X, Jia F, Guo X, Wang Z (2015) Impedimetric aptamer-based determination of the mold toxin fumonisin B1. Microchim Acta 182(9–10):1709–1714. https://doi.org/10.1007/s00604-015-1492-xCrossRef

116.

Commission Regulation (EU) No 165/2010 (2010) Commission Regulation (EU) No 165/2010 of 26 February 2010 amending Regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards aflatoxins

117.

Karapetis S, Nikolelis D, Hianik T (2018) Label-free and redox markers-based electrochemical aptasensors for aflatoxin M1 detection. Sensors 18(12):4218. https://doi.org/10.3390/s18124218CrossRef

118.

Malir F, Ostry V, Pfohl-Leszkowicz A, Malir J, Toman J (2016) Ochratoxin A: 50 years of research. Toxins 8(7):191. https://doi.org/10.3390/toxins8070191CrossRefPubMedCentral

119.

Amézqueta S, González-Peñas E, Murillo M, López de Cerain A (2004) Validation of a high-performance liquid chromatography analytical method for ochratoxin A quantification in cocoa beans. Food Addit Contam 21(11):1096–1106. https://doi.org/10.1080/02652030400019422CrossRefPubMed

120.

Yoo SM, Lee SY (2016) Optical biosensors for the detection of pathogenic microorganisms. Trends Biotechnol 34(1):7–25. https://doi.org/10.1016/j.tibtech.2015.09.012CrossRefPubMed

121.

Amiri M, Bezaatpour A, Jafari H, Boukherroub R, Szunerits S (2018) Electrochemical methodologies for the detection of pathogens. ACS Sensors 3(6):1069–1086. https://doi.org/10.1021/acssensors.8b00239CrossRefPubMed

122.

Arora P, Sindhu A, Dilbaghi N, Chaudhury A (2011) Biosensors as innovative tools for the detection of food borne pathogens. Biosens Bioelectron 28(1):1–12. https://doi.org/10.1016/j.bios.2011.06.002CrossRefPubMed

123.

Teng J, Yuan F, Ye Y, Zheng L, Yao L, Xue F, Chen W, Li B (2016) Aptamer-based technologies in foodborne pathogen detection. Front Microbiol 7:1426–1426. https://doi.org/10.3389/fmicb.2016.01426CrossRefPubMedPubMedCentral

124.

Kant K, Shahbazi M-A, Dave VP, Ngo TA, Chidambara VA, Than LQ, Bang DD, Wolff A (2018) Microfluidic devices for sample preparation and rapid detection of foodborne pathogens. Biotechnol Adv 36(4):1003–1024. https://doi.org/10.1016/j.biotechadv.2018.03.002CrossRefPubMed

125.

Labib M, Zamay AS, Kolovskaya OS, Reshetneva IT, Zamay GS, Kibbee RJ, Sattar SA, Zamay TN, Berezovski MV (2012) Aptamer-based viability impedimetric sensor for bacteria. Anal Chem 84(21):8966–8969. https://doi.org/10.1021/ac302902sCrossRefPubMed

126.

Jia F, Duan N, Wu S, Dai R, Wang Z, Li X (2015) Impedimetric Salmonella aptasensor using a glassy carbon electrode modified with an electrodeposited composite consisting of reduced graphene oxide and carbon nanotubes. Microchim Acta 183(1):337–344. https://doi.org/10.1007/s00604-015-1649-7CrossRef

127.

Bagheryan Z, Raoof JB, Golabi M, Turner APF, Beni V (2016) Diazonium-based impedimetric aptasensor for the rapid label-free detection of Salmonella typhimurium in food sample. Biosens Bioelectron 80:566–573. https://doi.org/10.1016/j.bios.2016.02.024CrossRefPubMed

128.

Sheikhzadeh E, Chamsaz M, Turner APF, Jager EWH, Beni V (2016) Label-free impedimetric biosensor for Salmonella typhimurium detection based on poly [pyrrole-co-3-carboxyl-pyrrole] copolymer supported aptamer. Biosens Bioelectron 80:194–200. https://doi.org/10.1016/j.bios.2016.01.057CrossRefPubMed

129.

Ma X, Jiang Y, Jia F, Yu Y, Chen J, Wang Z (2014) An aptamer-based electrochemical biosensor for the detection of Salmonella. J Microbiol Methods 98:94–98. https://doi.org/10.1016/j.mimet.2014.01.003CrossRefPubMed

130.

Ranjbar S, Shahrokhian S, Nurmohammadi F (2018) Nanoporous gold as a suitable substrate for preparation of a new sensitive electrochemical aptasensor for detection of Salmonella typhimurium. Sensors Actuators B Chem 255:1536–1544. https://doi.org/10.1016/j.snb.2017.08.160CrossRef

131.

Salam F, Tothill IE (2009) Detection of Salmonella typhimurium using an electrochemical immunosensor. Biosens Bioelectron 24(8):2630–2636. https://doi.org/10.1016/j.bios.2009.01.025CrossRefPubMed

132.

Ozalp VC, Bayramoglu G, Kavruk M, Keskin BB, Oktem HA, Arica MY (2014) Pathogen detection by core-shell type aptamer-magnetic preconcentration coupled to real-time PCR. Anal Biochem 447:119–125. https://doi.org/10.1016/j.ab.2013.11.022CrossRefPubMed

133.

Labib M, Zamay AS, Kolovskaya OS, Reshetneva IT, Zamay GS, Kibbee RJ, Sattar SA, Zamay TN, Berezovski MV (2012) Aptamer-based impedimetric sensor for bacterial typing. Anal Chem 84(19):8114–8117. https://doi.org/10.1021/ac302217uCrossRefPubMed

134.

Dua P, Ren S, Lee SW, Kim JK, Shin HS, Jeong OC, Kim S, Lee DK (2016) Cell-SELEX based identification of an RNA aptamer for Escherichia coli and its use in various detection formats. Mol Cells 39(11):807–813. https://doi.org/10.14348/molcells.2016.0167CrossRefPubMedPubMedCentral

135.

Burrs SL, Bhargava M, Sidhu R, Kiernan-Lewis J, Gomes C, Claussen JC, McLamore ES (2016) A paper based graphene-nanocauliflower hybrid composite for point of care biosensing. Biosens Bioelectron 85:479–487. https://doi.org/10.1016/j.bios.2016.05.037CrossRefPubMed

136.

Yao L, Wang L, Huang F, Cai G, Xi X, Lin J (2018) A microfluidic impedance biosensor based on immunomagnetic separation and urease catalysis for continuous-flow detection of E. coli O157:H7. Sensors Actuators B Chem 259:1013–1021. https://doi.org/10.1016/j.snb.2017.12.110CrossRef

137.

Vanegas DC, Rong Y, Schwalb N, Hills KD, Gomes C, McLamore ES (2015) Rapid detection of listeria spp. using an internalin A aptasensor based on carbon-metal nanohybrid structures. In: Proceedings of SPIE – smart biomedical and physiological sensor technology XIISPIE Sensing Technology + Applications. SPIE, Baltimore. https://doi.org/10.1117/12.2177441CrossRef

138.

Sidhu R, Rong Y, Vanegas DC, Claussen J, McLamore ES, Gomes C (2016) Impedance biosensor for the rapid detection of listeria spp. based on aptamer functionalized Pt-interdigitated microelectrodes array. In: Cullum BM, Kiehl D, McLamore ES (eds) Proceedings of SPIE – smart biomedical and physiological sensor technology XIIISPIE Commercial + Scientific Sensing and Imaging. SPIE, Baltimore. https://doi.org/10.1117/12.2223443CrossRef

139.

Jia F, Duan N, Wu S, Ma X, Xia Y, Wang Z, Wei X (2014) Impedimetric aptasensor for Staphylococcus aureus based on nanocomposite prepared from reduced graphene oxide and gold nanoparticles. Microchim Acta 181(9–10):967–974. https://doi.org/10.1007/s00604-014-1195-8CrossRef

140.

Reich P, Stoltenburg R, Strehlitz B, Frense D, Beckmann D (2017) Development of an impedimetric aptasensor for the detection of Staphylococcus aureus. Int J Mol Sci 18(11):2484. https://doi.org/10.3390/ijms18112484CrossRefPubMedCentral

141.

Xiong X, Shi X, Liu Y, Lu L, You J (2018) An aptamer-based electrochemical biosensor for simple and sensitive detection of staphylococcal enterotoxin B in milk. Anal Methods 10(3):365–370. https://doi.org/10.1039/c7ay02452eCrossRef

142.

Commission Regulation (EC) No 2073/2005 (2005) Commission Regulation (EC) No 2073/2005 of 15 November 2005 on microbiological criteria for foodstuffs

143.

Lee YJ, Han SR, Maeng J-S, Cho Y-J, Lee S-W (2012) In vitro selection of Escherichia coli O157:H7-specific RNA aptamer. Biochem Biophys Res Commun 417(1):414–420. https://doi.org/10.1016/j.bbrc.2011.11.130CrossRefPubMed

144.

Rubab M, Shahbaz HM, Olaimat AN, Oh D-H (2018) Biosensors for rapid and sensitive detection of Staphylococcus aureus in food. Biosens Bioelectron 105:49–57. https://doi.org/10.1016/j.bios.2018.01.023CrossRefPubMed

145.

Evenson ML, Ward Hinds M, Bernstein RS, Bergdoll MS (1988) Estimation of human dose of staphylococcal enterotoxin A from a large outbreak of staphylococcal food poisoning involving chocolate milk. Int J Food Microbiol 7(4):311–316. https://doi.org/10.1016/0168-1605(88)90057-8CrossRefPubMed

146.

Benvidi A, Banaei M, Tezerjani MD, Molahosseini H, Jahanbani S (2017) Impedimetric PSA aptasensor based on the use of a glassy carbon electrode modified with titanium oxide nanoparticles and silk fibroin nanofibers. Mikrochim Acta 185(1):50. https://doi.org/10.1007/s00604-017-2589-1CrossRefPubMed

147.

Yang ZH, Zhuo Y, Yuan R, Chai YQ (2017) Amplified impedimetric aptasensor combining target-induced DNA hydrogel formation with pH-stimulated signal amplification for the heparanase assay. Nanoscale 9(7):2556–2562. https://doi.org/10.1039/c6nr08353fCrossRefPubMed

148.

He L, Zhang S, Ji H, Wang M, Peng D, Yan F, Fang S, Zhang H, Jia C, Zhang Z (2016) Protein-templated cobaltous phosphate nanocomposites for the highly sensitive and selective detection of platelet-derived growth factor-BB. Biosens Bioelectron 79:553–560. https://doi.org/10.1016/j.bios.2015.12.095CrossRefPubMed

149.

Jahanbani S, Benvidi A (2016) Comparison of two fabricated aptasensors based on modified carbon paste/oleic acid and magnetic bar carbon paste/Fe3O4@oleic acid nanoparticle electrodes for tetracycline detection. Biosens Bioelectron 85:553–562. https://doi.org/10.1016/j.bios.2016.05.052CrossRefPubMed

150.

Jarczewska M, Kékedy-Nagy L, Nielsen JS, Campos R, Kjems J, Malinowska E, Ferapontova EE (2015) Electroanalysis of pM-levels of urokinase plasminogen activator in serum by phosphorothioated RNA aptamer. Analyst 140(11):3794–3802. https://doi.org/10.1039/c4an02354dCrossRefPubMed

151.

Chen Z, Chen L, Ma H, Zhou T, Li X (2013) Aptamer biosensor for label-free impedance spectroscopy detection of potassium ion based on DNA G-quadruplex conformation. Biosens Bioelectron 48:108–112. https://doi.org/10.1016/j.bios.2013.04.007CrossRefPubMed

152.

Shi P, Zhang Y, Yu Z, Zhang S (2017) Label-free electrochemical detection of ATP based on amino-functionalized metal-organic framework. Sci Rep 7(1):6500. https://doi.org/10.1038/s41598-017-06858-wCrossRefPubMedPubMedCentral

153.

Gopinath SC (2007) Methods developed for SELEX. Anal Bioanal Chem 387(1):171–182. https://doi.org/10.1007/s00216-006-0826-2CrossRefPubMed

154.

Stoltenburg R, Reinemann C, Strehlitz B (2007) SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands. Biomol Eng 24(4):381–403. https://doi.org/10.1016/j.bioeng.2007.06.001CrossRefPubMed

155.

Wehbe M, Labib M, Muharemagic D, Zamay AS, Berezovski MV (2015) Switchable aptamers for biosensing and bioseparation of viruses (SwAps-V). Biosens Bioelectron 67:280–286. https://doi.org/10.1016/j.bios.2014.08.033CrossRefPubMed

156.

Radi AE, O’Sullivan CK (2006) Aptamer conformational switch as sensitive electrochemical biosensor for potassium ion recognition. Chem Commun 32:3432–3434. https://doi.org/10.1039/b606804aCrossRef

157.

Zhang Z, Yang W, Wang J, Yang C, Yang F, Yang X (2009) A sensitive impedimetric thrombin aptasensor based on polyamidoamine dendrimer. Talanta 78(4–5):1240–1245. https://doi.org/10.1016/j.talanta.2009.01.034CrossRefPubMed

158.

Su W, Lin M, Lee H, Cho M, Choe WS, Lee Y (2012) Determination of endotoxin through an aptamer-based impedance biosensor. Biosens Bioelectron 32(1):32–36. https://doi.org/10.1016/j.bios.2011.11.009CrossRefPubMed

159.

Xu H, Gorgy K, Gondran C, Le Goff A, Spinelli N, Lopez C, Defrancq E, Cosnier S (2013) Label-free impedimetric thrombin sensor based on poly(pyrrole-nitrilotriacetic acid)-aptamer film. Biosens Bioelectron 41:90–95. https://doi.org/10.1016/j.bios.2012.07.044CrossRefPubMed

160.

Tran DT, Vermeeren V, Grieten L, Wenmackers S, Wagner P, Pollet J, Janssen KP, Michiels L, Lammertyn J (2011) Nanocrystalline diamond impedimetric aptasensor for the label-free detection of human IgE. Biosens Bioelectron 26(6):2987–2993. https://doi.org/10.1016/j.bios.2010.11.053CrossRefPubMed

161.

Du Y, Li B, Wei H, Wang Y, Wang E (2008) Multifunctional label-free electrochemical biosensor based on an integrated aptamer. Anal Chem 80(13):5110–5117. https://doi.org/10.1021/ac800303cCrossRefPubMed

162.

Yurkovetsky ZR, Linkov FY, Malehorn DE, Lokshin AE (2006) Multiple biomarker panels for early detection of ovarian cancer. Future Oncol 2(6):733–741. https://doi.org/10.2217/14796694.2.6.733CrossRefPubMed

163.

Komarova E, Reber K, Aldissi M, Bogomolova A (2010) New multispecific array as a tool for electrochemical impedance spectroscopy-based biosensing. Biosens Bioelectron 25(6):1389–1394. https://doi.org/10.1016/j.bios.2009.10.034CrossRefPubMed

164.

Lee J, Cho S, Lee J, Ryu H, Park J, Lim S, Oh B, Lee C, Huang W, Busnaina A, Lee H (2013) Wafer-scale nanowell array patterning based electrochemical impedimetric immunosensor. J Biotechnol 168(4):584–588. https://doi.org/10.1016/j.jbiotec.2013.08.029CrossRefPubMed

165.

Periyakaruppan A, Arumugam PU, Meyyappan M, Koehne JE (2011) Detection of ricin using a carbon nanofiber based biosensor. Biosens Bioelectron 28(1):428–433. https://doi.org/10.1016/j.bios.2011.07.061CrossRefPubMed

166.

Qureshi A, Gurbuz Y, Niazi JH (2010) Label-free detection of cardiac biomarker using aptamer based capacitive biosensor. Procedia Eng 5:828–830. https://doi.org/10.1016/j.proeng.2010.09.236CrossRef

167.

Lim T, Lee SY, Yang J, Hwang SY, Ahn Y (2016) Microfluidic biochips for simple impedimetric detection of thrombin based on label-free DNA aptamers. Biochip J 11(2):109–115. https://doi.org/10.1007/s13206-016-1203-7CrossRef

168.

Lum J, Wang R, Hargis B, Tung S, Bottje W, Lu H, Li Y (2015) An impedance aptasensor with microfluidic chips for specific detection of H5N1 avian influenza virus. Sensors 15(8):18565–18578. https://doi.org/10.3390/s150818565CrossRefPubMed

169.

Wang Y, Ye Z, Ping J, Jing S, Ying Y (2014) Development of an aptamer-based impedimetric bioassay using microfluidic system and magnetic separation for protein detection. Biosens Bioelectron 59:106–111. https://doi.org/10.1016/j.bios.2014.03.015CrossRefPubMed

170.

Zubtsov DA, Ivanov SM, Rubina AY, Dementieva EI, Chechetkin VR, Zasedatelev AS (2006) Effect of mixing on reaction–diffusion kinetics for protein hydrogel-based microchips. J Biotechnol 122(1):16–27. https://doi.org/10.1016/j.jbiotec.2005.08.010CrossRefPubMed

171.

Feng S, Chen C, Wang W, Que L (2018) An aptamer nanopore-enabled microsensor for detection of theophylline. Biosens Bioelectron 105:36–41. https://doi.org/10.1016/j.bios.2018.01.016CrossRefPubMed

172.

Liao W, Cui XT (2007) Reagentless aptamer based impedance biosensor for monitoring a neuro-inflammatory cytokine PDGF. Biosens Bioelectron 23(2):218–224. https://doi.org/10.1016/j.bios.2007.04.004CrossRefPubMed

173.

Keefe AD, Cload ST (2008) SELEX with modified nucleotides. Curr Opin Chem Biol 12(4):448–456. https://doi.org/10.1016/j.cbpa.2008.06.028CrossRefPubMed

174.

The Eyetech Study Group (2003) Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results. Ophthalmology 110(5):979–986. https://doi.org/10.1016/S0161-6420(03)00085-XCrossRef

175.

González-Fernández E, de-los-Santos-Álvarez N, Lobo-Castañón MJ, Miranda-Ordieres AJ, Tuñón-Blanco P (2011) Impedimetric aptasensor for tobramycin detection in human serum. Biosens Bioelectron 26(5):2354–2360. https://doi.org/10.1016/j.bios.2010.10.011CrossRefPubMed

176.

Rowe AA, Miller EA, Plaxco KW (2010) Reagentless measurement of aminoglycoside antibiotics in blood serum via an electrochemical, ribonucleic acid aptamer-based biosensor. Anal Chem 82(17):7090–7095. https://doi.org/10.1021/ac101491dCrossRefPubMedPubMedCentral

Title: Impedimetric Aptamer-Based Biosensors: Applications
Authors: John-Alexander Preuß
Peggy Reich
Nicole Bahner
Janina Bahnemann
Publisher: Springer International Publishing
Book: Aptamers in Biotechnology
Print ISBN: 978-3-030-54060-9

Electronic ISBN: 978-3-030-54061-6

Copyright Year: 2020
DOI: https://doi.org/10.1007/10_2020_125