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The Complex Geometry of the Mandelbrot Set Read chapter Read first chapter

2014 | OriginalPaper | Chapter

Inference of Optimized Control Strategies for Genetic Networks

Author : Natalja Strelkowa

Published in: ISCS 2013: Interdisciplinary Symposium on Complex Systems

Publisher: Springer Berlin Heidelberg

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Abstract

In this chapter we present the application of control theoretical concepts to stochastic dynamical systems which are based on the current knowledge of genetic networks. We showcase the application of reinforcement learning algorithm inferring an optimized control strategy for a genetic switch reversal. The approach does not require precise knowledge of gene network mathematical equations and is therefore also applicable to experimentally obtained time traces.

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Literature
1.
Csete, M.E., Doyle, J.C.: Reverse engineering of biological complexity. Science 295, 1664–1669 (2002)CrossRef
2.
Ivanova, N., Dobrin, R., Lu, R., Kotenko, I., Levorse, J., et al.: Dissecting self-renewal in stem cells with rna interference. Nature 442, 533–538 (2006)CrossRef
3.
Liu, Y., Asakura, M., Inoue, H., Nakamura, T., Sano, M., et al.: Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc. Natl. Acad. Sci. USA 104, 3859–3864 (2007)CrossRef
4.
Mettetal, J.T., Muzzey, D., Gomez-Uribe, C., van Oudenaarden, A.: The frequency dependence of Osmo-adaptation in Saccharomyces cerevisiae. Science 319, 482–484 (2008)CrossRef
5.
Shimizu-Sato, S., Huq, E., Tepperman, J.M., Quail, P.H.: A light-switchable gene promoter system. Nat. Biotech. 20, 1041–1044 (2002)CrossRef
6.
Levskaya, A., Weiner, O.D., Lim, W.A., Voigt, C.A.: Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature 461, 997–1001 (2009)CrossRef
7.
Ernst, D., Geurts, P., Wehenkel, L.: Tree-based batch mode reinforcement learning. J. Mach. Learn. Res. 6, 503–556 (2005)MATHMathSciNet
8.
Andrianantoandro, E., Basu, S., Karig, D.K., Weiss, R.: Synthetic biology: new engineering rules for an emerging discipline. Mol. Sys. Bio. 2(2006), 0028 (2006)
9.
Waddington, C.H.: Organisers and Genes. Cambridge Univ Press, Cambridge, UK (1940)
10.
Graf, T., Enver, T.: Forcing cells to change lineages. Nature 462, 587–594 (2009)CrossRef
11.
12.
Strelkowa, N., Barahona, M.: Switchable genetic oscillator operating in quasi-stable mode. J. R. Soc. Interface 7, 1071–1082 (2010)CrossRef
13.
Strelkowa, N.: How Nature Works. Springer International Publishing, Switzerland (chapter Stochastic Complexity Analysis in Synthetic Biology. Emergence, Complexity and Computation, Vol. 5) (2013)
14.
Gardner, T., Cantor, C.R., Collins, J.J.: Construction of a genetic toggle switch in escherichia coli. Nature 403, 339–342 (2000)CrossRef
15.
Guantes, R., Poyatos, J.F.: Dynamical principles of two-component genetic oscillators. PLoS Comput. Biol. 2, e30 (2006)CrossRef
16.
Swain, P.S., Elowitz, M.B., Siggia, E.D.: Intrinsic and extrinsic contributions to stochasticity in gene expression. Proceedings of the National Academy of Sciences of the United States of America, vol. 99, pp. 12795–12800 (2002)
17.
Geurts, P., Ernst, D., Wehenkel, L.: Extremely randomized trees. Mach. Learn. 63, 3–42 (2006)CrossRefMATH
18.
Cai, L., Friedman, N., Xie, X.S.: Stochastic protein expression in individual cells at the single molecule level. Nature 440, 358–362 (2006)CrossRef
19.
Bennett, M.R., Hasty, J.: Microfluidic devices for measuring gene network dynamics in single cells. Nat. Rev. Genet. 10, 628–638 (2009)CrossRef
Metadata
Title
Inference of Optimized Control Strategies for Genetic Networks
Author
Natalja Strelkowa
Copyright Year
2014
Publisher
Springer Berlin Heidelberg
Book
ISCS 2013: Interdisciplinary Symposium on Complex Systems

Print ISBN: 978-3-642-45437-0

Electronic ISBN: 978-3-642-45438-7

Copyright Year: 2014

DOI
https://doi.org/10.1007/978-3-642-45438-7_26

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