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Acta Mechanica Sinica
Published in: Acta Mechanica Sinica 6/2019

24-06-2019 | Research Paper

Influence of coronary bifurcation angle on atherosclerosis

Authors: Zhaomiao Liu, Shengwei Zhao, Yunjie Li, Feng Shen, Yipeng Qi, Qi Wang

Published in: Acta Mechanica Sinica | Issue 6/2019

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Abstract

Hemodynamics plays a crucial role in the development and progression of coronary atherosclerosis, which is prone to occur in branch bifurcation. An individual aortic-coronary artery model and three changed bifurcation angle models are constructed by Mimics and Freeform based on computed tomography angiography. The influence of different coronary bifurcation angles between left main (LM), left anterior descending (LAD), and left circumflex (LCX) on the blood flow field and related hemodynamic parameters are studied. It is shown that a wider bifurcation angle between LAD and LCX can cause a wider low-wall shear stress area, leading to atherosclerosis. Similarly, a decreased angle between LM and LAD is predisposed to prevent atherosclerosis. The results help to better understand the hemodynamic causes of atherosclerosis with various bifurcation angles in coronary arteries and to provide guidance for clinical assessment and prevention.
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Metadata
Title
Influence of coronary bifurcation angle on atherosclerosis
Authors
Zhaomiao Liu
Shengwei Zhao
Yunjie Li
Feng Shen
Yipeng Qi
Qi Wang
Publication date
24-06-2019
Publisher
The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences
Published in
Acta Mechanica Sinica / Issue 6/2019
Print ISSN: 0567-7718
Electronic ISSN: 1614-3116
DOI
https://doi.org/10.1007/s10409-019-00878-7

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