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A Brief Study on the Heterogeneity of the P91 Welded Joint Read chapter Read first chapter

2020 | OriginalPaper | Chapter

Influence of Particle Morphologies of Mesoporous Hydroxyapatite Nanopowders on Controlled Delivery of Vancomycin Drug

Authors : Ravinder Pal Singh, Jagdeep Singh

Published in: Advances in Materials Science and Engineering

Publisher: Springer Singapore

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Abstract

Mesoporous hydroxyapatite (HAP) nanopowders (NPs) with distinct particle morphologies of nanorods (HAP-NR) and hierarchically nanostructured microspheres (HAP-MS) were synthesized. HAP was a major phase in both products. Crystals were nanodimensional and exposed to tensile strain. HAP-NR was more crystalline than HAP-MS NP. Particles of HAP-NR and HAP-MS NPs were nanorod-like (aspect ratio of five to six) and hierarchically nanostructured microspheres in shape, respectively. Average particle size was 88 ± 30 nm (along c-axis) for HAP-NR and 1.5–2 µm for HAP-MS NP. EDX results were in agreement with XRD phase analysis. Specific surface areas of HAP-NR and HAP-MS NPs were 15 m2 g−1 and 22 m2 g1, respectively. HAP-MS NP was more porous than HAP-NR and, therefore, exhibited 45% higher vancomycin loading efficiency than HAP-NR NP. In addition, drug-releasing rate of HAP-MS NP was more than HAP-NR in simulated conditions.

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Metadata
Title
Influence of Particle Morphologies of Mesoporous Hydroxyapatite Nanopowders on Controlled Delivery of Vancomycin Drug
Authors
Ravinder Pal Singh
Jagdeep Singh
Copyright Year
2020
Publisher
Springer Singapore
Book
Advances in Materials Science and Engineering

Print ISBN: 978-981-15-4058-5

Electronic ISBN: 978-981-15-4059-2

Copyright Year: 2020

DOI
https://doi.org/10.1007/978-981-15-4059-2_7

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