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Published in:
Intelligent Hydrogels as Drug Delivery Systems Read chapter Read first chapter

2018 | OriginalPaper | Chapter

12. Injectable Hydrogels for Cartilage Regeneration

Authors : Cenk Celik, Vishal T. Mogal, James Hoi Po Hui, Xian Jun Loh, Wei Seong Toh

Published in: Hydrogels

Publisher: Springer Singapore

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Abstract

Articular cartilage injuries have a limited potential to heal, which over time, may lead to osteoarthritis, an inflammatory and degenerative joint disease associated with activity-related pain, swelling, and impaired mobility. Regeneration and restoration of joint tissue and function remain unmet challenges. Intra-articular injections of therapeutic agents are effective to some extent, but often require multiple injections. In the past decade, injectable hydrogels have emerged as promising biomaterials, due largely to their biocompatibility, tissue extracellular matrix (ECM) mimicry, excellent permeability, and easy adaptation for minimal-invasive procedures. Moreover, hydrogels can be designed as carriers for sustained release of therapeutic agents and protective matrices for cell delivery. This chapter provides an overview of the injectable hydrogel systems currently being applied together with therapeutic drug delivery and/or cell therapy for treatment of cartilage lesions and osteoarthritis.

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previous chapter Cellulose Hydrogels; Fabrication, Properties, and Their Application to Biocompatible and Tissue Engineering
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Metadata
Title
Injectable Hydrogels for Cartilage Regeneration
Authors
Cenk Celik
Vishal T. Mogal
James Hoi Po Hui
Xian Jun Loh
Wei Seong Toh
Copyright Year
2018
Publisher
Springer Singapore
Book
Hydrogels

Print ISBN: 978-981-10-6076-2

Electronic ISBN: 978-981-10-6077-9

Copyright Year: 2018

DOI
https://doi.org/10.1007/978-981-10-6077-9_12

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