Top

Journal of Materials Science

Published in:

16-05-2021 | Polymers & biopolymers

Injectable hydrogels with two different rates of drug release based on pluronic/water system filled with poly(ε-caprolactone) microcapsules

Authors: Beatriz Delgado, Henrique Carrêlo, Mónica V. Loureiro, Ana C. Marques, João Paulo Borges, Maria Teresa Cidade

Published in: Journal of Materials Science | Issue 23/2021

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

The present paper regards the preparation and characterization of Pluronic F127 + F68/water/poly (ε-caprolactone) microcapsules (MCs) composite systems for tissue repair. The first part of the work relates to the production of poly(ε-caprolactone) (PCL) MCs via water-in-oil-in-water (W/O/W) double emulsion system combined with solvent evaporation method. The study of different process parameters in the final MCs characteristics and their drug release profile is herein reported. Different percentages of PCL, emulsion stabilizer, and volume proportions of the emulsion constituents have been tested, leading to considerable differences in the MCs size distributions. The selected MCs, containing an aqueous solution of methylene blue (MB) as a model drug, were then used to fill a Pluronic F127 + F68/water system leading to the final composite system (5 and 10 wt % MB loaded PCL MCs). The composite systems were characterised in the second part of the work in terms of its rheological behaviour and drug release performance. They were found to gellify at 30 °C, and present an extended drug release to a total of 18 days. The models that best define the release profiles were also studied, with the release of MB occurring mostly by Fick diffusion and polymer chain relaxation. Pluronic F127 + F68/water/poly (ε-caprolactone) MCs composite system is shown to be a promising injectable system, with two different drug release rates, for tissue repair.

previous article Design of a double aging treatment for the improvement of mechanical and microstructural properties of pulse micro-plasma arc welded alloy 718

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Kan GM (2001) Controlled release oral dosage forms: some recent advances in matrix type drug delivery systems. J Med Sci 1:350–354CrossRef

Tomaro-Duchesneau C, Saha S, Malhotra M, Kahouli I, Prakash S (2013) Microencapsulation for the therapeutic delivery of drugs, live mammalian and bacterial cells, and other biopharmaceutics: current status and future directions. J Pharm. https://doi.org/10.1155/2013/103527CrossRef

Varde NK, Pack DW (2004) Microcapsules for controlled release drug delivery. Expert Opin Biol Ther 4:35–41CrossRef

Davoodi P, Lee LY, Xu Q, Sunil V, Sun Y, Soh S, Wang C-H (2018) Drug delivery systems for programmed and on-demand release. Adv Drug Deliv Rev 132:104–138CrossRef

Wang X, Wang Y, Wei K, Zhao N, Zhang S, Chen J (2009) Drug distribution within poly(ε-caprolactone) microcapsules and in vitro release. J Mater Process Technol 209:348–354CrossRef

Pohlmann AR, Fonseca FN, Paese K, Detoni CB, Coradini K, Beck RC, Guterres SS (2013) Poly(e-caprolactone) microcapsules and nanocapsules in drug delivery. Expert Opin Drug Deliv 10:623–638CrossRef

Iqbal M, Valour J-P, Fessi H, Elaissari A (2015) Preparation of biodegradable PCL particles via double emulsion evaporation method using ultrasound technique. Colloid Polym Sci 293:861–873CrossRef

Lamprecht A, Ubrich N, Pérez MH, Lehr C-M, Hoffman M, Maincent P (2000) Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int J Pharm 196:177–182CrossRef

Hwang Y-M, Pan C-T, Lin Y-M, Zeng S-W, Yen C-K, Wang S-Y, Kuo S-W, Ju S-P, Liang S-S, Liu Z-H (2019) Preparation of biodegradable polycaprolactone microcarriers with doxorubicin hydrochloride by ultrasonic-assisted emulsification technology. Sens Mater 31:301–310

10.

Imbrogno A, Dragosavac MM, Piacentini E, Vladisavljević GT, Holdich RG, Giorno L (2015) Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes. Colloids Surf B Biointerfaces 135:116–125CrossRef

11.

Yang Y-Y, Chung T-S, Ng N-P (2001) Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microcapsules containing protein fabricated by double-emulsion solvent extraction/evaporation method. Biomaterials 22:231–241CrossRef

12.

Seifriz W (1925) Studies in Emulsions III-V. J Phys Chem 29:738–749CrossRef

13.

Cesari A, Loureiro MV, Vale M, Yslas EI, Dardanelli M, Marques AC (2020) Polycaprolactone microcapsules containing citric acid and naringin for plant growth and sustainable agriculture physico-chemical properties and release behaviour. Sci Total Environ 703:135548. https://doi.org/10.1016/j.scitotenv.2019.135548CrossRef

14.

Loureiro MV, Vale M, Galhano Lopes R, Matos S, Bordado JC, Pinho I, Marques AC (2020) Microencapsulation of isocyanate in biodegradable poly(ε-caprolactone) capsules and application in monocomponent green adhesives. ACS Appl Polym Mater 2(11):4425–4438. https://doi.org/10.1021/acsapm.0c00535CrossRef

15.

Ibraheem D, Iqbal M, Agusti G, Fessi H, Elaissari A (2014) Effects of process parameters on the colloidal properties of polycaprolactone microparticles prepared by double emulsion like process. Colloids Surf A Physicochem Eng Asp 445:79–91. https://doi.org/10.1016/j.colsurfa.2014.01.012CrossRef

16.

Caramella C, Conti B, Modena T, Ferrari F, Bonferoni MC, Genta I, Rossi S, Torre ML, Sandri G, Sorrenti M, Catenacci L, Dorati R, Tripodo G (2016) Controlled delivery systems for tissue repair and regeneration. J Drug Deliv Sci Technol 32:206–228CrossRef

17.

Wang P, Johnston TP (1991) Kinetics of sol-to-gel transition for poloxamer polyols. J Appl Polym Sci 43:283–292CrossRef

18.

Zhang Y, Song W, Geng J, Chitgupi U, Unsal H, Federizon J, Rzayev J, Sukumaran DK, Alexandridis P, Lovell JF (2016) Therapeutic surfactant-stripped frozen micelles. Nat. Commun. 7(1):1–9

19.

Zhang Y, Wang D, Goel S, Sun B, Chitgupi U, Geng J, Sun H, Barnhart TE, Cai W, Xia J (2016) Surfactant-stripped frozen pheophytin micelles for multimodal gut imaging. Adv Mater 28:8524–8530CrossRef

20.

Hoffman AS (2012) Hydrogels for biomedical applications. Adv Drug Deliv Rev 64:18–23CrossRef

21.

Peppas NA, Bures P, Leobandung W, Ichikawa H (2007) Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50:27–46CrossRef

22.

Gnavi S, Di Blasio L, Tonda-Turo C, Macardi A, Primo L, Ciardelli G, Gambarotta G, Geuna S, Perroteau I (2014) Gelatin based hydrogels as delivery systems for vascular endothelial growth factor release in peripheral nerve tissue engineering. J Tissue Eng Regen Med 11:459–470CrossRef

23.

Tonda-Turo C, Gnavi S, Ruini F, Gambarotta G, Gioffredi E, Chiono V, Perroteau I, Ciardelli G (2014) Development and characterisation of novel agar and gelatin injectable hydrogel as filler for peripheral nerve guidance channel. J Tissue Eng Regen Med 11(197):208

24.

Tan H, Marra KG (2010) Injectable, biodegradable hydrogels for tissue engineering applications. Materials 3:1746–1767CrossRef

25.

Tipton AJ (2000) Dunn, In situ gelling systems. In: Senior J, Radomsky ML (eds) Sustained-release injectable products, 1st edn. CRC Press, Boca Raton, FL, USA, pp 241–278CrossRef

26.

Hollister LE (1989) Site-specific drug delivery to CNS: Old and new. Neurobiol Aging 10:631CrossRef

27.

Alexandridis P, Hatton TA (1995) Poly (ethylene oxide)- poly (propylene oxide)- poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surf A 96:1–46CrossRef

28.

Wanka G, Hoffmann H, Ulbricht W (1994) Phase diagrams and aggregation behavior of poly (oxyethylene)-poly (oxypropylene)-poly (oxyethylene) triblock copolymers in aqueous solutions. Macromolecules 27:4145–4159CrossRef

29.

Zhang M, Djabourov M, Bourgaux C, Bouchemal K (2013) Nanostructured fluids from pluronic® mixtures. Int J Pharm 454:599–610CrossRef

30.

Al Khateb K, Ozhmukhametova EK, Mussin MN, Seilkhanov SK, Rakhypbekov TK, ManLau W, Khutoryanskiy VV (2016) In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery. Int J Pharm 502:70–79CrossRef

31.

Cidade MT, Ramos DJ, Santos J, Carrelo H, Calero N, Borges JP (2019) Injectable hydrogels based on pluronic/water systems filled with alginate microparticles for biomedical applications. Materials 12:1083CrossRef

32.

Weidenauer U, Bodmer D, Kissel T (2003) Microencapsulation of hydrophilic drug substances using biodegradable polyesters. Part I: evaluation of different techniques for the encapsulation of pamidronate disodium salt. J Microencapsul. 20:509–524CrossRef

33.

Zhou J, Fang T, Wen J, Shao Z (2011) Silk coating on poly(ε-caprolactone) microcapsules for the delayed release of vancomycin. J Microencapsul 28:99–107CrossRef

34.

Yu X, Wang N, Lv S (2016) Crystal and multiple melting behaviors of PCL lamellae in ultrathin films. J Cryst Growth 438:11–18CrossRef

35.

Smith B (2017) The carbonyl group, part I: introduction. Spectroscopy 32:31–36

36.

Elzein T, Nasser-Eddine M, Delaite C, Bistac S, Dumas P (2004) FTIR study of polycaprolactone chain organization at interfaces. J Colloid Interface Sci 273:381–387CrossRef

37.

Ovchinniko OV, Evtukhova AV, Kondratenko TS, Smirnov MS, Khokhlov VY, Erina OV (2016) Manifestation of intermolecular interactions in FTIR spectra of methylene blue molecules. Vib Spectrosc 86:181–189CrossRef

38.

Xia Y, Yao Q, Zhang W, Zhang Y, Zhao M (2015) Comparative adsorption of methylene blue by magnetic baker’s yeast and EDTAD-modified magnetic baker’s yeast: equilibrium and kinetic study. Arab J Chem 12:2448–2456CrossRef

39.

Batenburg LF, Fischer H (2001) PlanoColors® a combination of organic dyes and layered silicates with nanometer dimensions. e-Polymers

40.

Lu X, Katz JS, Schmitt AK, Moore JS (2018) A robust oil-in-oil emulsion for the nonaqueous encapsulation of hydrophilic payloads. J Am Chem Soc 140:3619–3625CrossRef

41.

Calero N, Santos J, Echevarría C, Muñoz J, Cidade MT (2018) Time-dependent behavior in analyte-, temperature-, and shear-sensitive pluronic pe9400/water systems. Colloid Polym Sci 296:1515–1522CrossRef

42.

Lau BK, Wang Q, Sun W, Li L (2004) Micellization to gelation of a triblock copolymer in water: thermoreversibility and scaling. J Polym Sci B 42:2014–2025CrossRef

Title: Injectable hydrogels with two different rates of drug release based on pluronic/water system filled with poly(ε-caprolactone) microcapsules
Authors: Beatriz Delgado
Henrique Carrêlo
Mónica V. Loureiro
Ana C. Marques
João Paulo Borges
Maria Teresa Cidade
Publication date: 16-05-2021
Publisher: Springer US
Published in: Journal of Materials Science / Issue 23/2021
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-021-06156-x

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Other articles of this Issue 23/2021

pH-responsive smart superwetting Fe foam for efficient in situ on-demand oil/water separation

Novel synthesis and electrochemical investigations of ZnO/C composites for lithium-ion batteries

Boronate affinity-modified magnetic β-cyclodextrin polymer for selective separation and adsorption of shikimic acid

The synthesis and nanostructure investigation of noble metal-based nanocomposite materials

Structural and electronic characteristics of Fe-doped β-Ga2O3 single crystals and the annealing effects

Investigation on crack behavior of Ni60A alloy coating produced by coaxial laser cladding

Premium Partners