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Technical Physics
Published in: Technical Physics 9/2018

01-09-2018 | DEVELOPMENT OF PROCESS TECHNOLOGIES, DIAGNOSTIC METHODS, AND FUNCTIONAL MATERIALS AND STRUCTURES

Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica

Authors: S. V. Shmakov, V. V. Klimenko, S. V. Konyakhin, D. A. Eurov, D. A. Kurdyukov, V. G. Golubev

Published in: Technical Physics | Issue 9/2018

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Abstract

Сomposite particles based on monodisperse spherical mesoporous silica particles (MSMSPs) are synthesized by noncovalent binding of organic active components (propidium iodide fluorescent dye and Radakchlorin photosensitizer) from aqueous solutions. Hybrid particles with a core–shell structure are synthesized, which are MSMSPs filled with Fe3O4 and coated with mesoporous silica, the internal surface of which is modified by Fluorescein isothiocyanate (FITC) fluorescence dye by means of chemisorption. The toxicity and penetration of the obtained particles into the cells of the HeLa and K-562 cell lines were studied. The effective photodynamic action of MSMSPs containing Radachlorin in mesopores is demonstrated, which indicates the promise of using the synthesized composite particles for medical purposes.
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Metadata
Title
Investigation of Toxic Effect and Penetration into Cells of Monodisperse Spherical Composite Particles Based on Mesoporous Silica
Authors
S. V. Shmakov
V. V. Klimenko
S. V. Konyakhin
D. A. Eurov
D. A. Kurdyukov
V. G. Golubev
Publication date
01-09-2018
Publisher
Pleiades Publishing
Published in
Technical Physics / Issue 9/2018
Print ISSN: 1063-7842
Electronic ISSN: 1090-6525
DOI
https://doi.org/10.1134/S1063784218090190

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