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LAURDAN Fluorescence Properties in Membranes: A Journey from the Fluorometer to the Microscope Read chapter Read first chapter

2013 | OriginalPaper | Chapter

Lateral Membrane Heterogeneity Probed by FRET Spectroscopy and Microscopy

Authors : Luís M. S. Loura, Manuel Prieto

Published in: Fluorescent Methods to Study Biological Membranes

Publisher: Springer Berlin Heidelberg

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Abstract

Förster resonance energy transfer (FRET) is a photophysical process highly dependent on interchromophore distance. Due to this feature, it is very sensitive to membrane lateral heterogeneity, as the donor and acceptor fluorophores involved in FRET tend to have different preference for distinct types of lipid bilayer domains. In this chapter, the basic formalisms of FRET in situations of increasing complexity (from a single donor-acceptor pair at a fixed distance to non-random probe distribution) are presented and illustrated with selected examples from the literature. The importance of time-resolved fluorescence data is emphasized. It is shown that FRET can be used to study the occurrence of domain formation, allowing their detection as well as size estimation. Lateral lipid distribution heterogeneity may also result from peptide- or protein-lipid interaction. Formalisms that apply to these situations are also presented, as well as selected examples of their use. Applications of FRET under the microscope have recently come to the fore, and representative studies are mentioned.

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previous chapter 3-Hydroxychromone Probes Precisely Located and Oriented in Lipid Bilayers: A Toolkit for Biomembrane Research
next chapter FRET Analysis of Protein-Lipid Interactions
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Metadata
Title
Lateral Membrane Heterogeneity Probed by FRET Spectroscopy and Microscopy
Authors
Luís M. S. Loura
Manuel Prieto
Copyright Year
2013
Publisher
Springer Berlin Heidelberg
Book
Fluorescent Methods to Study Biological Membranes

Print ISBN: 978-3-642-33127-5

Electronic ISBN: 978-3-642-33128-2

Copyright Year: 2013

DOI
https://doi.org/10.1007/4243_2012_59

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