2015 | OriginalPaper | Chapter
Magnetic Resonance Imaging Depiction of Non Thermal Irreversible Electroporation Treated Liver
Authors : Mohammad Hjouj, Jacob Lavee, Dianne Daniels, Shirley Sharabi, Yael Mardor, David Last, David Guez, Boris Rubinsky
Published in: 6th European Conference of the International Federation for Medical and Biological Engineering
Publisher: Springer International Publishing
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Non-thermal irreversible electroporation (NTIRE) is a minimally invasive tissue ablation modality in which pulsed electric fields are delivered across the cell to produce nanoscale defects in the cell membrane and cell death. Medical imaging is of great importance for any ablation technology for obtaining maximum treatment efficacy with minimum damage to surrounding normal tissue. Previous studies of medical imaging of NTIRE have focused primarily on the correlation between the extent of tissue ablation and the image. The purpose of the presented study was to seek a physiological interpretation of MRI images of NTIRE, rather than a correlation between the image and the extent of tissue death. To develop a fundamental understanding of the physiological significance of the MRI images, we compared MR imaging sequences of T1W, T2W, PD, T2 SPAIR, and STIR acquired after NTIRE treatment in a rodent liver model. The parameters that were studied include the presence or absence of a contrast agent and
in vivo
and
ex-vivo
NTIRE treatments in the same liver. The most striking observations is that the same MRI sequences that produce an image after NTIRE
in vivo
fail to produce an MRI image when NTIRE is delivered
ex-vivo
, within minutes after the excision of the organ. This tentatively suggests that the physiological interpretation of the MRI images is related to blood flow and blood flow phenomena.