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Biomaterial Surfaces for the Isolation of Hematopoietic Stem and Progenitor Cells Read chapter Read first chapter

2012 | OriginalPaper | Chapter

2. Matrix Stiffness: A Regulator of Cellular Behavior and Tissue Formation

Authors : Brooke N. Mason, Joseph P. Califano, Cynthia A. Reinhart-King

Published in: Engineering Biomaterials for Regenerative Medicine

Publisher: Springer New York

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Abstract

The extracellular environment is an essential mediator of cell health and provides both chemical and mechanical stimuli to influence single and collective cell behaviors. While historically there has been significant emphasis placed on chemical regulators within the extracellular matrix, the role of the mechanical environment is less well known. Here, we review the role of matrix mechanics on cell function and tissue integrity. Cellular responses to mechanical signals include differentiation, migration, proliferation, and alterations in cell–cell and cell–matrix adhesion. Interestingly, the mechanical properties of tissues are altered in many disease states, leading to cellular dysfunction and further disease progression. Successful regenerative medicine strategies must consider the native mechanical environment so that they are able to elicit a favorable cellular response and integrate into the native tissue structure.

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Metadata
Title
Matrix Stiffness: A Regulator of Cellular Behavior and Tissue Formation
Authors
Brooke N. Mason
Joseph P. Califano
Cynthia A. Reinhart-King
Copyright Year
2012
Publisher
Springer New York
Book
Engineering Biomaterials for Regenerative Medicine

Print ISBN: 978-1-4614-1079-9

Electronic ISBN: 978-1-4614-1080-5

Copyright Year: 2012

DOI
https://doi.org/10.1007/978-1-4614-1080-5_2

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