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Biomaterial Surfaces for the Isolation of Hematopoietic Stem and Progenitor Cells Read chapter Read first chapter

2012 | OriginalPaper | Chapter

3. Oxygen Supply for Tissue Engineering

Authors : Whitney L. Stoppel, Susan C. Roberts

Published in: Engineering Biomaterials for Regenerative Medicine

Publisher: Springer New York

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Abstract

Adequate oxygen transport is vital to the success of a tissue-engineered construct. Modulating oxygen tension within tissue-engineered constructs is necessary for the creation of devices with optimal functionality. Oxygen tension significantly influences cellular behavior through mechanisms which promote both cell proliferation and apoptosis. Given the negative consequences of low oxygen tension for most grafted tissues, many investigators have worked to improve oxygen tension within tissue engineered scaffolds through the use of synthetic oxygen carriers, natural or artificial heme, and polymeric oxygen generating thin films, or by inducing blood vessel growth into the matrix. Cellular oxygen consumption and transport within a scaffold can be calculated and predicted using diffusion models to improve device design. This section explores the interplay between fundamental engineering and biological processes used to modulate oxygen tension for the creation of functional tissue-engineered devices.

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previous chapter Matrix Stiffness: A Regulator of Cellular Behavior and Tissue Formation
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Metadata
Title
Oxygen Supply for Tissue Engineering
Authors
Whitney L. Stoppel
Susan C. Roberts
Copyright Year
2012
Publisher
Springer New York
Book
Engineering Biomaterials for Regenerative Medicine

Print ISBN: 978-1-4614-1079-9

Electronic ISBN: 978-1-4614-1080-5

Copyright Year: 2012

DOI
https://doi.org/10.1007/978-1-4614-1080-5_3

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