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2012 | OriginalPaper | Chapter

9. Metal-Containing Nano-Antimicrobials: Differentiating the Impact of Solubilized Metals and Particles

Authors : Angela Ivask, Saji George, Olesja Bondarenko, Anne Kahru

Published in: Nano-Antimicrobials

Publisher: Springer Berlin Heidelberg

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Abstract

Metal-based antiseptics like silver, zinc oxide, copper and titanium dioxide have proven their efficacy long time before nanorevolution. The rapid development of nanotechnology during the past ten years has allowed even further increases in their antimicrobial potency. Indeed, the development and use of nano-Ag or nano-Cu/CuO coated surfaces and application of ZnO and TiO2 nanoparticles in personal care products is rapidly increasing. The main reason for the increased efficacy of nano-size metal-based antiseptics compared to their micro-sized counterparts is their increased relative surface area that translates into higher reactivity, e.g., improved dissolution of inhibitory concentrations of metal ions. In this chapter, we discuss the recent findings on the antimicrobial mechanisms of metal-based nanomaterials with special emphasis on metal dissolution. We also discuss the (bio)analytical methods that have been developed and/or applied to discriminate between the toxic effects mediated by metal dissolution and nanomaterials per se. The discrimination between these two mechanisms of toxicity is important for basic mechanistic research as well as for designing new nano-antimicrobials.

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Metadata
Title
Metal-Containing Nano-Antimicrobials: Differentiating the Impact of Solubilized Metals and Particles
Authors
Angela Ivask
Saji George
Olesja Bondarenko
Anne Kahru
Copyright Year
2012
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-24428-5_9