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Advances in Manufacturing
Published in: Advances in Manufacturing 3/2021

13-06-2020

Modeling the density gradient of 3D nanofiber scaffolds fabricated by divergence electrospinning

Authors: Muhammad Adib Uz Zaman, Dilshan Sooriyaarachchi, Ying-Ge Zhou, George Z. Tan, Dong-Ping Du

Published in: Advances in Manufacturing | Issue 3/2021

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Abstract

Following recent insights on structure-cell-function interactions and the critical role of the extracellular matrix (ECM), the latest biofabrication approaches have increasingly focused on designing materials with biomimetic microarchitecture. Divergence electrospinning is a novel fabrication method for three-dimensional (3D) nanofiber scaffolds. It is introduced to produce 3D nanofiber mats that have numerous applications in regenerative medicine and tissue engineering. One of the most important characteristics of 3D nanofiber mats is the density gradient. This study provides a statistical analysis and response surface modeling framework based on experimental data to evaluate the manner by which the geometric designs of double-bevel collectors influence the fiber density gradient. Specifically, variance of analysis and sensitivity analysis were performed to identify parameters that had significant effects, and a response surface model embedded with seven location indicators was developed to predict the spatial distribution of fiber density for different collector designs. It was concluded that the collector height, bevel angle, and their interactions were significant factors influencing the density gradient. This study revealed the sensitivity of system configuration and provided an optimization tool for process controllability of microstructure gradients.
previous article Failure mode analysis on compression of lattice structures with internal cooling channels produced by laser powder bed fusion
next article Three-dimensional modeling and reconstructive change of residual stress during machining process of milling, polishing, heat treatment, vibratory finishing, and shot peening of fan blade

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Metadata
Title
Modeling the density gradient of 3D nanofiber scaffolds fabricated by divergence electrospinning
Authors
Muhammad Adib Uz Zaman
Dilshan Sooriyaarachchi
Ying-Ge Zhou
George Z. Tan
Dong-Ping Du
Publication date
13-06-2020
Publisher
Shanghai University
Published in
Advances in Manufacturing / Issue 3/2021
Print ISSN: 2095-3127
Electronic ISSN: 2195-3597
DOI
https://doi.org/10.1007/s40436-020-00307-0

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