Top

Journal of Computational Neuroscience

Published in:

19-04-2020

Modelling acute and lasting effects of tDCS on epileptic activity

Authors: Yves Denoyer, Isabelle Merlet, Fabrice Wendling, Pascal Benquet

Published in: Journal of Computational Neuroscience | Issue 2/2020

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Transcranial Direct brain stimulation (tDCS) is commonly used in order to modulate cortical networks activity during physiological processes through the application of weak electrical fields with scalp electrodes. Cathodal stimulation has been shown to decrease brain excitability in the context of epilepsy, with variable success. However, the cellular mechanisms responsible for the acute and the long-lasting effect of tDCS remain elusive. Using a novel approach of computational modeling that combines detailed but functionally integrated neurons we built a physiologically-based thalamocortical column. This model comprises 10,000 individual neurons made of pyramidal cells, and 3 types of gamma-aminobutyric acid (GABA) -ergic cells (VIP, PV, and SST) respecting the anatomy, layers, projection, connectivity and neurites orientation. Simulating realistic electric fields in term of intensity, main results showed that 1) tDCS effects are best explained by modulation of the presynaptic probability of release 2) tDCS affects the dynamic of cortical network only if a sufficient number of neurons are modulated 3)VIP GABAergic interneurons of the superficial layer of the cortex are especially affected by tDCS 4) Long lasting effect depends on glutamatergic synaptic plasticity.

previous article A computational model for grid maps in neural populations

next article A hierarchical model of perceptual multistability involving interocular grouping

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Abraham, W. C. (2008). Metaplasticity: Tuning synapses and networks for plasticity. Nature Reviews Neuroscience, 9(5), 387–387. https://doi.org/10.1038/nrn2356.CrossRefPubMed

Arain, F. M., Boyd, K. L., & Gallagher, M. J. (2012). Decreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor α1 subunit. Epilepsia, 53(8), e161–e165. https://doi.org/10.1111/j.1528-1167.2012.03596.x.CrossRefPubMedPubMedCentral

Attwell, D., & Gibb, A. (2005). Neuroenergetics and the kinetic design of excitatory synapses. Nature Reviews Neuroscience, 6(11), 841–849. https://doi.org/10.1038/nrn1784.CrossRefPubMed

Avramescu, S., & Timofeev, I. (2008). Synaptic strength modulation after cortical trauma: A role in Epileptogenesis. Journal of Neuroscience, 28(27), 6760–6772. https://doi.org/10.1523/JNEUROSCI.0643-08.2008.CrossRefPubMed

Biabani, M., Aminitehrani, M., Zoghi, M., Farrell, M., Egan, G., & Jaberzadeh, S. (2018). The effects of transcranial direct current stimulation on short-interval intracortical inhibition and intracortical facilitation: A systematic review and meta-analysis. Reviews in the Neurosciences, 29(1), 99–114. https://doi.org/10.1515/revneuro-2017-0023.CrossRefPubMed

Bienenstock, E. L., Cooper, L. N., & Munro, P. W. (1982). Theory for the development of neuron selectivity: Orientation specificity and binocular interaction in visual cortex. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 2(1), 32–48.CrossRef

Bikson, M., Ghai, R. S., Baraban, S. C., & Durand, D. M. (1999). Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity. Journal of Neurophysiology, 82, 2262–2270.CrossRef

Bikson, M., Inoue, M., Akiyama, H., Deans, J. K., Fox, J. E., Miyakawa, H., & Jefferys, J. G. R. (2004). Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro. The Journal of Physiology, 557(Pt 1), 175–190. https://doi.org/10.1113/jphysiol.2003.055772.CrossRefPubMedPubMedCentral

Braitenberg, V., & Schüz, A. (2013). Cortex: Statistics and geometry of neuronal connectivity. Springer Science & Business Media.

Branco, T., & Staras, K. (2009). The probability of neurotransmitter release: Variability and feedback control at single synapses. Nature Reviews Neuroscience, 10(5), 373–383.CrossRef

Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L. H., & Moore, C. I. (2009). Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature, 459(7247), 663–667. https://doi.org/10.1038/nature08002.CrossRefPubMedPubMedCentral

Cooper, L. N., & Bear, M. F. (2012). The BCM theory of synapse modification at 30: Interaction of theory with experiment. Nature Reviews Neuroscience, 13(11), 798–810.CrossRef

Cossart, R., Dinocourt, C., Hirsch, J. C., Merchan-Perez, A., De Felipe, J., Ben-Ari, Y., et al. (2001). Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy. Nature Neuroscience, 4(1), 52–62. https://doi.org/10.1038/82900.CrossRefPubMed

Datta, A., Bansal, V., Diaz, J., Patel, J., Reato, D., & Bikson, M. (2009). Gyri-precise head model of transcranial direct current stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad. Brain Stimulation, 2, 201–207.e1.

Dayan, E., Censor, N., Buch, E. R., Sandrini, M., & Cohen, L. G. (2013). Noninvasive brain stimulation: From physiology to network dynamics and back. Nature Neuroscience, 16(7), 838–844. https://doi.org/10.1038/nn.3422.CrossRefPubMedPubMedCentral

Esmaeilpour, Z., Marangolo, P., Hampstead, B. M., Bestmann, S., Galletta, E., Knotkova, H., et al. (2018). Incomplete evidence that increasing current intensity of tDCS boosts outcomes. Brain Stimulation, 11, 310–321.CrossRef

Farrant, M., & Nusser, Z. (2005). Variations on an inhibitory theme: Phasic and tonic activation of GABAA receptors. Nature Reviews Neuroscience, 6(3), 215–229. https://doi.org/10.1038/nrn1625.CrossRefPubMed

Fauth, M., Wörgötter, F., & Tetzlaff, C. (2015). The formation of multi-synaptic connections by the interaction of synaptic and structural plasticity and their functional consequences. PLoS Computational Biology, 11(1), e1004031. https://doi.org/10.1371/journal.pcbi.1004031.CrossRefPubMedPubMedCentral

Filmer, H. L., Dux, P. E., & Mattingley, J. B. (2014). Applications of transcranial direct current stimulation for understanding brain function. Trends in Neurosciences, 37(12), 742–753. https://doi.org/10.1016/j.tins.2014.08.003.CrossRefPubMed

Fisher, R. S., van Emde Boas, W., Blume, W., Elger, C., Genton, P., Lee, P., & Engel, J. (2005). Epileptic seizures and epilepsy: definitions proposed by the international league against epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 46(4), 470–472. https://doi.org/10.1111/j.0013-9580.2005.66104.x.CrossRefPubMed

Fritsch, B., Reis, J., Martinowich, K., Schambra, H. M., Ji, Y., Cohen, L. G., & Lu, B. (2010). Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning. Neuron, 66(2), 198–204. https://doi.org/10.1016/j.neuron.2010.03.035.CrossRefPubMedPubMedCentral

Ghai, R. S., Bikson, M., & Durand, D. M. (2000). Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices. Journal of Neurophysiology, 84, 274–280.CrossRef

Gil, Z., Connors, B. W., & Amitai, Y. (1999). Efficacy of Thalamocortical and Intracortical synaptic connections: Quanta, innervation, and reliability. Neuron, 23(2), 385–397. https://doi.org/10.1016/S0896-6273(00)80788-6.CrossRefPubMed

González, O. C., Krishnan, G. P., Chauvette, S., Timofeev, I., Sejnowski, T., & Bazhenov, M. (2015). Modeling of age-dependent Epileptogenesis by differential homeostatic synaptic scaling. Journal of Neuroscience, 35(39), 13448–13462. https://doi.org/10.1523/JNEUROSCI.5038-14.2015.CrossRefPubMed

Gschwind, M., & Seeck, M. (2016). Transcranial direct-current stimulation as treatment in epilepsy. Expert Review of Neurotherapeutics, 16(12), 1427–1441. https://doi.org/10.1080/14737175.2016.1209410.CrossRefPubMed

Harris, K. D., & Mrsic-Flogel, T. D. (2013). Cortical connectivity and sensory coding. Nature, 503(7474), 51–58. https://doi.org/10.1038/nature12654.CrossRefPubMed

Harris, K. D., & Shepherd, G. M. G. (2015). The neocortical circuit: Themes and variations. Nature Neuroscience, 18(2), 170–181. https://doi.org/10.1038/nn.3917.CrossRefPubMedPubMedCentral

Hiratani, N., & Fukai, T. (2018). Redundancy in synaptic connections enables neurons to learn optimally. Proceedings of the National Academy of Sciences of the United States of America, 115(29), E6871–E6879. https://doi.org/10.1073/pnas.1803274115.CrossRefPubMedPubMedCentral

Jackson, M. P., Rahman, A., Lafon, B., Kronberg, G., Ling, D., Parra, L. C., & Bikson, M. (2016). Animal models of transcranial direct current stimulation: Methods and mechanisms. Clinical Neurophysiology, 127(11), 3425–3454. https://doi.org/10.1016/j.clinph.2016.08.016.CrossRefPubMedPubMedCentral

Jefferys, J. G. R., Deans, J., Bikson, M., & Fox, J. (2003). Effects of weak electric fields on the activity of neurons and neuronal networks. Radiation Protection Dosimetry, 106, 321–323.

Jehi, L. (2018). The epileptogenic zone: Concept and definition. Epilepsy Currents, 18(1), 12–16. https://doi.org/10.5698/1535-7597.18.1.12.CrossRefPubMedPubMedCentral

Ji, X., Zingg, B., Mesik, L., Xiao, Z., Zhang, L. I., & Tao, H. W. (2016). Thalamocortical innervation pattern in mouse auditory and visual cortex: Laminar and cell-type specificity. Cerebral Cortex (New York, NY), 26(6), 2612–2625. https://doi.org/10.1093/cercor/bhv099.CrossRef

Jiang, X., Shen, S., Cadwell, C. R., Berens, P., Sinz, F., Ecker, A. S., et al. (2015). Principles of connectivity among morphologically defined cell types in adult neocortex. Science (New York, N.Y.), 350(6264), aac9462. https://doi.org/10.1126/science.aac9462.CrossRef

Kabakov, A. Y., Muller, P. A., Pascual-Leone, A., Jensen, F. E., & Rotenberg, A. (2012). Contribution of axonal orientation to pathway-dependent modulation of excitatory transmission by direct current stimulation in isolated rat hippocampus. Journal of Neurophysiology, 107(7), 1881–1889. https://doi.org/10.1152/jn.00715.2011.CrossRefPubMedPubMedCentral

Krause, B., Márquez-Ruiz, J., & Kadosh, R. C. (2013). The effect of transcranial direct current stimulation: A role for cortical excitation/inhibition balance? Frontiers in Human Neuroscience, 7. https://doi.org/10.3389/fnhum.2013.00602.

Kuramoto, E., Furuta, T., Nakamura, K. C., Unzai, T., Hioki, H., & Kaneko, T. (2009). Two types of Thalamocortical projections from the motor thalamic nuclei of the rat: A single neuron-tracing study using viral vectors. Cerebral Cortex, 19(9), 2065–2077. https://doi.org/10.1093/cercor/bhn231.CrossRefPubMed

Kurbatova, P., Wendling, F., Kaminska, A., Rosati, A., Nabbout, R., Guerrini, R., et al. (2016). Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome. Experimental Neurology, 283(Pt A), 57–72. https://doi.org/10.1016/j.expneurol.2016.05.037.CrossRef

Lefaucheur, J.-P., Antal, A., Ayache, S. S., Benninger, D. H., Brunelin, J., Cogiamanian, F., Cotelli, M., de Ridder, D., Ferrucci, R., Langguth, B., Marangolo, P., Mylius, V., Nitsche, M. A., Padberg, F., Palm, U., Poulet, E., Priori, A., Rossi, S., Schecklmann, M., Vanneste, S., Ziemann, U., Garcia-Larrea, L., & Paulus, W. (2017). Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology, 128(1), 56–92. https://doi.org/10.1016/j.clinph.2016.10.087.CrossRef

Leite, J. P., Neder, L., Arisi, G. M., Carlotti, C. G., Assirati, J. A., & Moreira, J. E. (2005). Plasticity, synaptic strength, and epilepsy: What can we learn from ultrastructural data? Epilepsia, 46(s5), 134–141.CrossRef

Lévesque, M., Herrington, R., Hamidi, S., & Avoli, M. (2016). Interneurons spark seizure-like activity in the entorhinal cortex. Neurobiology of Disease, 87, 91–101. https://doi.org/10.1016/j.nbd.2015.12.011.CrossRefPubMed

Liebetanz, D., Nitsche, M. A., Tergau, F., & Paulus, W. (2002). Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain: A Journal of Neurology, 125(Pt 10), 2238–2247.CrossRef

Lopantsev, V., Both, M., & Draguhn, A. (2009). Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges. European Journal of Neuroscience, 29(6), 1153–1164. https://doi.org/10.1111/j.1460-9568.2009.06663.x.CrossRefPubMed

Lopes da Silva, F. H., Vos, J. E., Mooibroek, J., & van Rotterdam, A. (1980). Relative contributions of intracortical and thalamo-cortical processes in the generation of alpha rhythms, revealed by partial coherence analysis. Electroencephalography and Clinical Neurophysiology, 50(5), 449–456. https://doi.org/10.1016/0013-4694(80)90011-5.CrossRefPubMed

Malenka, R. C., & Bear, M. F. (2004). LTP and LTD: An embarrassment of riches. Neuron, 44(1), 5–21.CrossRef

Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004). Interneurons of the neocortical inhibitory system. Nature Reviews Neuroscience, 5(10), 793–807. https://doi.org/10.1038/nrn1519.CrossRefPubMed

Márquez-Ruiz, J., Leal-Campanario, R., Sánchez-Campusano, R., Molaee-Ardekani, B., Wendling, F., Miranda, P. C., Ruffini, G., Gruart, A., & Delgado-García, J. M. (2012). Transcranial direct-current stimulation modulates synaptic mechanisms involved in associative learning in behaving rabbits. Proceedings of the National Academy of Sciences of the United States of America, 109(17), 6710–6715. https://doi.org/10.1073/pnas.1121147109.CrossRefPubMedPubMedCentral

McGuire, B. A., Wiesel, T. N., & Gilbert, C. D. (1984). Input to layer 4 of cat striate. The Journal of Neuroscience, 4(12), 13.

Meador, K. J. (2007). The basic science of memory as it applies to epilepsy: Basic science of memory as it applies to epilepsy. Epilepsia, 48, 23–25. https://doi.org/10.1111/j.1528-1167.2007.01396.x.CrossRefPubMed

Meyer, H. S., Wimmer, V. C., Oberlaender, M., de Kock, C. P. J., Sakmann, B., & Helmstaedter, M. (2010). Number and laminar distribution of neurons in a Thalamocortical projection column of rat Vibrissal cortex. Cerebral Cortex, 20(10), 2277–2286. https://doi.org/10.1093/cercor/bhq067.CrossRefPubMed

Miranda, P. C., Lomarev, M., & Hallett, M. (2006). Modeling the current distribution during transcranial direct current stimulation. Clinical Neurophysiology, 117, 1623–1629.

Modolo, J., Denoyer, Y., Wendling, F., Benquet, P. (2018). Physiological effects of low-magnitude electric fields on brain activity: advances from in vitro, in vivo and in silico models. Current Opinion Biomedical Engineering, 8, 38–44.CrossRef

Mohan, H., Verhoog, M. B., Doreswamy, K. K., Eyal, G., Aardse, R., Lodder, B. N., Goriounova, N. A., Asamoah, B., B Brakspear, A. B., Groot, C., van der Sluis, S., Testa-Silva, G., Obermayer, J., Boudewijns, Z. S., Narayanan, R. T., Baayen, J. C., Segev, I., Mansvelder, H. D., & de Kock, C. P. (2015). Dendritic and axonal architecture of individual pyramidal neurons across layers of adult human Neocortex. Cerebral Cortex, 25(12), 4839–4853. https://doi.org/10.1093/cercor/bhv188.CrossRef

Mountcastle, V. B. (1997). The columnar organization of the neocortex. Brain, 120(4), 701–722. https://doi.org/10.1093/brain/120.4.701.CrossRef

Murakami, S., & Okada, Y. (2006). Contributions of principal neocortical neurons to magnetoencephalography and electroencephalography signals: MEG/EEG signals of neocortical neurons. The Journal of Physiology, 575(3), 925–936. https://doi.org/10.1113/jphysiol.2006.105379.CrossRefPubMedPubMedCentral

Naruse, Y., Matani, A., Miyawaki, Y., & Okada, M. (2010). Influence of coherence between multiple cortical columns on alpha rhythm: A computational modeling study. Human Brain Mapping, 31(5), 703–715. https://doi.org/10.1002/hbm.20899.CrossRefPubMed

Nitsche, M. A., & Paulus, W. (2001). Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology, 57(10), 1899–1901.CrossRef

Nitsche, M. A., Fricke, K., Henschke, U., Schlitterlau, A., Liebetanz, D., Lang, N., et al. (2003). Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans. The Journal of Physiology, 553(Pt 1), 293–301. https://doi.org/10.1113/jphysiol.2003.049916.CrossRefPubMedPubMedCentral

O’Kusky, J., & Colonnier, M. (1982). A laminar analysis of the number of neurons, glia, and synapses in the visual cortex (area 17) of adult macaque monkeys. The Journal of Comparative Neurology, 210(3), 278–290. https://doi.org/10.1002/cne.902100307.CrossRefPubMed

Packer, A. M., McConnell, D. J., Fino, E., & Yuste, R. (2013). Axo-dendritic overlap and laminar projection can explain interneuron connectivity to pyramidal cells. Cerebral Cortex (New York, N.Y.: 1991), 23(12), 2790–2802. https://doi.org/10.1093/cercor/bhs210.CrossRef

Pelletier, S. J., Lagacé, M., St-Amour, I., Arsenault, D., Cisbani, G., Chabrat, A., et al. (2015). The morphological and molecular changes of brain cells exposed to direct current electric field stimulation. International Journal of Neuropsychopharmacology, 18(5). https://doi.org/10.1093/ijnp/pyu090.CrossRef

Peters, A., Payne, B. R., & Budd, J. (1994). A numerical analysis of the Geniculocortical input to striate cortex in the monkey. Cerebral Cortex, 4(3), 215–229. https://doi.org/10.1093/cercor/4.3.215.CrossRefPubMed

Pitkänen, A., & Engel, J. (2014). Past and present definitions of Epileptogenesis and its biomarkers. Neurotherapeutics, 11(2), 231–241. https://doi.org/10.1007/s13311-014-0257-2.CrossRefPubMedPubMedCentral

Prönneke, A., Scheuer, B., Wagener, R. J., Möck, M., Witte, M., & Staiger, J. F. (2015). Characterizing VIP neurons in the barrel cortex of VIPcre/tdTomato mice reveals layer-specific differences. Cerebral Cortex, 25(12), 4854–4868. https://doi.org/10.1093/cercor/bhv202.CrossRefPubMed

Purves, D., Augustine, G. J., Fitzpatrick, D., Katz, L. C., LaMantia, A.-S., McNamara, J. O., & Williams, S. M. (2001). An Overview of Cortical Structure. http://www.ncbi.nlm.nih.gov/books/NBK10870/. .

Rahman, A., Reato, D., Arlotti, M., Gasca, F., Datta, A., Parra, L. C., & Bikson, M. (2013). Cellular effects of acute direct current stimulation: Somatic and synaptic terminal effects. The Journal of Physiology, 591(10), 2563–2578.CrossRef

Rahman, A., Lafon, B., Parra, L. C., & Bikson, M. (2017). Direct current stimulation boosts synaptic gain and cooperativity in vitro. The Journal of Physiology, 595(11), 3535–3547. https://doi.org/10.1113/JP273005.CrossRefPubMedPubMedCentral

Reato, D., Rahman, A., Bikson, M., & Parra, L. C. (2010). Low-intensity electrical stimulation affects network dynamics by modulating population rate and spike timing. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 30(45), 15067–15079. https://doi.org/10.1523/JNEUROSCI.2059-10.2010.CrossRef

Rudy, B., Fishell, G., Lee, S., & Hjerling-Leffler, J. (2011). Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons. Developmental Neurobiology, 71(1), 45–61. https://doi.org/10.1002/dneu.20853.CrossRefPubMedPubMedCentral

Sadleir, R. J., Vannorsdall, T. D., Schretlen, D. J., & Gordon, B. (2010). Transcranial direct current stimulation (tDCS) in a realistic head model. NeuroImage, 51, 1310–1318.

San-juan, D., Morales-Quezada, L., Orozco Garduño, A. J., Alonso-Vanegas, M., González-Aragón, M. F., Espinoza López, D. A., et al. (2015). Transcranial direct current stimulation in epilepsy. Brain Stimulation, 8(3), 455–464. https://doi.org/10.1016/j.brs.2015.01.001.CrossRefPubMed

Sellaro, R., Derks, B., Nitsche, M. A., Hommel, B., van den Wildenberg, W. P. M., van Dam, K., & Colzato, L. S. (2015). Reducing prejudice through brain stimulation. Brain Stimulation, 8(5), 891–897. https://doi.org/10.1016/j.brs.2015.04.003.CrossRefPubMed

Shamas, M., Benquet, P., Merlet, I., Khalil, M., El Falou, W., Nica, A., & Wendling, F. (2018). On the origin of epileptic high frequency oscillations observed on clinical electrodes. Clinical Neurophysiology, 129(4), 829–841. https://doi.org/10.1016/j.clinph.2018.01.062.CrossRefPubMed

Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009). Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature, 459(7247), 698–702. https://doi.org/10.1038/nature07991.CrossRefPubMedPubMedCentral

Spruston, N. (2008). Pyramidal neurons: Dendritic structure and synaptic integration. Nature Reviews Neuroscience, 9(3), 206–221. https://doi.org/10.1038/nrn2286.CrossRefPubMed

Squire, L. R. (2013). Fundamental Neuroscience. Academic Press.

Stagg, C. J., Best, J. G., Stephenson, M. C., O’Shea, J., Wylezinska, M., Kincses, Z. T., et al. (2009). Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 29(16), 5202–5206. https://doi.org/10.1523/JNEUROSCI.4432-08.2009.CrossRef

Stagg, C. J., Antal, A., & Nitsche, M. A. (2018). Physiology of Transcranial Direct Current Stimulation: The Journal of ECT, 1. https://doi.org/10.1097/YCT.0000000000000510.CrossRef

Swann, J. W., & Rho, J. M. (2014). How is homeostatic plasticity important in epilepsy? Advances in Experimental Medicine and Biology, 813, 123–131. https://doi.org/10.1007/978-94-017-8914-1_10.CrossRefPubMed

Thomson, A. M., & Bannister, A. P. (2003). Interlaminar connections in the neocortex. Cerebral Cortex, 13(1), 5–14.CrossRef

Thomson, A. M., & Lamy, C. (2007). Functional maps of neocortical local circuitry. Frontiers in Neuroscience, 1, 19–42. https://doi.org/10.3389/neuro.01.1.1.002.2007.CrossRef

Tlamsa, A. P., & Brumberg, J. C. (2010). Organization and morphology of thalamocortical neurons of mouse ventral lateral thalamus. Somatosensory & Motor Research, 27(1), 34–43. https://doi.org/10.3109/08990221003646736.CrossRef

Traub, R. D., Whittington, M. A., Stanford, I. M., & Jefferys, J. G. (1996). A mechanism for generation of long-range synchronous fast oscillations in the cortex. Nature, 383(6601), 621–624. https://doi.org/10.1038/383621a0.CrossRefPubMed

Tremblay, R., Lee, S., & Rudy, B. (2016). GABAergic interneurons in the Neocortex: From cellular properties to circuits. Neuron, 91(2), 260–292. https://doi.org/10.1016/j.neuron.2016.06.033.CrossRefPubMedPubMedCentral

Wang, Y., Toledo-Rodriguez, M., Gupta, A., Wu, C., Silberberg, G., Luo, J., & Markram, H. (2004). Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat. The Journal of Physiology, 561(Pt 1), 65–90. https://doi.org/10.1113/jphysiol.2004.073353.CrossRefPubMedPubMedCentral

Wendling, F., Bartolomei, F., Bellanger, J. J., & Chauvel, P. (2002). Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition. The European Journal of Neuroscience, 15(9), 1499–1508.CrossRef

Williams, L. E., & Holtmaat, A. (2019). Higher-order Thalamocortical inputs gate synaptic long-term potentiation via Disinhibition. Neuron, 101(1), 91-102.e4. https://doi.org/10.1016/j.neuron.2018.10.049.CrossRef

Wong, M., & Guo, D. (2013). Dendritic spine pathology in epilepsy: Cause or consequence? Neuroscience, 251, 141–150. https://doi.org/10.1016/j.neuroscience.2012.03.048.CrossRefPubMed

Zito, K., & Scheuss, V. (2009). NMDA receptor function and physiological modulation. In Encyclopedia of Neuroscience (pp. 1157–1164). Elsevier. http://linkinghub.elsevier.com/retrieve/pii/B9780080450469012250. Accessed 18 May 2016.

Title: Modelling acute and lasting effects of tDCS on epileptic activity
Authors: Yves Denoyer
Isabelle Merlet
Fabrice Wendling
Pascal Benquet
Publication date: 19-04-2020
Publisher: Springer US
Published in: Journal of Computational Neuroscience / Issue 2/2020
Print ISSN: 0929-5313
Electronic ISSN: 1573-6873
DOI: https://doi.org/10.1007/s10827-020-00745-6

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Wirtschaft"

Springer Professional "Technik"

Other articles of this Issue 2/2020

Dynamics of a neuron–glia system: the occurrence of seizures and the influence of electroconvulsive stimuli

A hierarchical model of perceptual multistability involving interocular grouping

Inference of synaptic connectivity and external variability in neural microcircuits

Ring models of binocular rivalry and fusion

Short term depression, presynaptic inhibition and local neuron diversity play key functional roles in the insect antennal lobe

A computational model for grid maps in neural populations

Premium Partner