2015 | OriginalPaper | Chapter
Novel Zwitterionic Nanocomposite Hydrogel as Effective Chronic Wound Healing Dressings
Authors : Kang-Ting Huang, Chun-Jen Huang
Published in: 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering
Publisher: Springer International Publishing
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We have synthesized and characterized a novel zwitterionic nanocomposite hydrogel as effective chronic wound healing dressings. The hydrogel is composited of nonfouling zwitterionic polymer as a major composition, plus small quantity of nano-sized clay for improved mechanical strength and in-situ formation silver nanoparticles for anti-microbial function. The novel zwitterionic nanocomposite hydrogel possesses unique features, including 1. biocmpatibility; 2. high water content; 3. anti-biofouling properties; 4. strong durability; 5. suppression of bacterial growth; 6. controlled release of Ag ions. These features allow developed formulation becoming extraordinary chronic wound dressing for clinical applications.The hydrogel was fabricated via a “one-pot synthesis” approach and the physicochemical properties were characterized detail. Moreover, the antifouling properties of hydrogels were evaluated in contact with a protein and bacterial solutions.