2015 | OriginalPaper | Chapter
Multi-walled Carbon Nanotubes and Chitosan Film Promote Nerve Regeneration by Releasing Nerve Growth Factor
Authors : Wei Chen Liao, Cheng Rung Yang, Meng Hsuan Lin, Yu Ting Lo, Yi Jhih Chiou, Yi Ling Hsieh, Mei Jung Chen, Pei Ru Chen
Published in: 1st Global Conference on Biomedical Engineering & 9th Asian-Pacific Conference on Medical and Biological Engineering
Publisher: Springer International Publishing
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The purpose of this study was to develop kinds of multi-walled carbon nanotubes (MWCNT)-based materials, which could replace current autografts for neuron regeneration. The alternative MWCNT films was developed by encapsulated chitosan. To evaluate the characteristics of MWCNT films after modification, the measurements of electrical conductivity, contact angle and the degree of degradation were carried out. Two kinds of chitosan film preparation were designed, one was the dish film and the other was microscope slide film. The microscope slide film was exterior, however, the dish film was wrinkling. Comparing the thickness by micrometer caliper, the thickness of the dish film was 0.1950 to 0.0425 mm, and the microscope slide film was 0.0584 to 0.0109 mm. This result indicated the microscope slide film was more suitable for the following experiment because of less error value. The contact angle of the chitosan film was measured between 60~90 deg, it indicated the film was more hydrophobic. In order to achieve better biocompatibility, adding MWCNT significantly increased hydrophilicity of chitosan film.