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Journal of Polymer Research

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01-03-2017 | SHORT COMMUNICATION

Octreotide end-functionalized diblock copolymers facilitated by RAFT polymerization

Author: Alexander W. Jackson

Published in: Journal of Polymer Research | Issue 4/2017

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Abstract

The incorporation of biologically active targeting ligands into polymeric materials is a key challenge in drug delivery and bioimaging. Reported here is the synthesis of diblock copolymers end-functionalized with the Somatostatin analog Octreotide. This methodology employs a novel Octreotide functional reversible addition-fragmentation chain transfer (RAFT) polymerization chain transfer agent, which is used to mediate the polymerization of N-isopropylacrylamide and subsequent chain-extension with N,N-dimethylacrylamide.

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Title: Octreotide end-functionalized diblock copolymers facilitated by RAFT polymerization
Author: Alexander W. Jackson
Publication date: 01-03-2017
Publisher: Springer Netherlands
Published in: Journal of Polymer Research / Issue 4/2017
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-017-1220-9

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