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Polymer Bulletin
Published in: Polymer Bulletin 7/2018

13-10-2017 | Original Paper

Optimisation of process parameters using D-optimal for enzymatic synthesis of polycaprolactone

Authors: Harshini Pakalapati, Anand Bellam Balaji, Senthil Kumar Arumugasamy, Mohammad Khalid

Published in: Polymer Bulletin | Issue 7/2018

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Abstract

This work emphasizes on reactor scale synthesis of polycaprolactone using ε-caprolactone as monomer and Candida antarctica lipase B enzyme as catalyst. The bio-polymerization was performed in 2 L thermostatic reactor by the conventional method with constant stirring. Optimisation of process parameters such as reactor temperature, reaction time, and mixing speed was carried out using response surface methodology based on D-optimal design. Molecular weight of the bio-polymer was chosen as the response for optimization, which is later characterised by gel permeation chromatography. The results show good agreement between predicted values and actual values obtained through the experiments.
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Metadata
Title
Optimisation of process parameters using D-optimal for enzymatic synthesis of polycaprolactone
Authors
Harshini Pakalapati
Anand Bellam Balaji
Senthil Kumar Arumugasamy
Mohammad Khalid
Publication date
13-10-2017
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 7/2018
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-017-2207-8

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