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Polymer Bulletin
Published in: Polymer Bulletin 7/2013

01-07-2013 | Original Paper

Osteogenic activities of polymeric soybean oil-g-polystyrene membranes

Authors: R. Seda Tığlı Aydın, Baki Hazer, Merve Acar, Menemşe Gümüşderelioğlu

Published in: Polymer Bulletin | Issue 7/2013

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Abstract

A novel biocompatible copolymer membrane was synthesized and characterized for use in guided bone regeneration using polymeric soybean oil-g-polystyrene (PSO-g-PS) graft copolymer which was successfully obtained by free radical polymerization of styrene initiated by PSO peroxide as a macroinitiator at 80 °C. Osteoblastic cellular activities of MC3T3-E1 cells on PSO-g-PS membranes with different soybean oil composition (PSO-g-PS1, PSO-g-PS2, and PSO-g-PS3) were evaluated. Nuclear magnetic resonance (1H NMR) spectra showed that PSO inclusion (mol%) was found to be 27, 69, and 51 % for PSO-g-PS1, PSO-g-PS2, and PSO-g-PS3 membranes, respectively. Superior biocompatibility of the PSO-g-PS membranes was determined compared to polystyrene tissue culture plates (TCPS) as positive control. Cell proliferation was enhanced on PSO-g-PS2 and PSO-g-PS3 membranes compared to PSO-g-PS1 membranes (p < 0.001), and a statistically significant higher ALP value of MC3T3-E1 cells on PSO-g-PS2 membranes (p < 0.05) suggested that proliferation and differentiation of preosteoblastic on PSO-g-PS membranes were enhanced with regard to soybean oil content within the membranes. Thus, the present study suggests that PSO-g-PS2 membranes, which showed a favorable biological environment for the preosteoblastic cells, can be well suited for bone tissue engineering applications.
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Metadata
Title
Osteogenic activities of polymeric soybean oil-g-polystyrene membranes
Authors
R. Seda Tığlı Aydın
Baki Hazer
Merve Acar
Menemşe Gümüşderelioğlu
Publication date
01-07-2013
Publisher
Springer-Verlag
Published in
Polymer Bulletin / Issue 7/2013
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-013-0976-2

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