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Published in: Experiments in Fluids 11/2017

01-11-2017 | Letter

Particle image velocimetry measurements in an anatomical vascular model fabricated using inkjet 3D printing

Authors: Kenneth I. Aycock, Prasanna Hariharan, Brent A. Craven

Published in: Experiments in Fluids | Issue 11/2017

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Abstract

For decades, the study of biomedical fluid dynamics using optical flow visualization and measurement techniques has been limited by the inability to fabricate transparent physical models that realistically replicate the complex morphology of biological lumens. In this study, we present an approach for producing optically transparent anatomical models that are suitable for particle image velocimetry (PIV) using a common 3D inkjet printing process (PolyJet) and stock resin (VeroClear). By matching the index of refraction of the VeroClear material using a room-temperature mixture of water, sodium iodide, and glycerol, and by printing the part in an orientation such that the flat, optical surfaces are at an approximately 45\(^{\circ }\) angle to the build plane, we overcome the challenges associated with using this 3D printing technique for PIV. Here, we summarize our methodology and demonstrate the process and the resultant PIV measurements of flow in an optically transparent anatomical model of the human inferior vena cava.

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Literature
go back to reference Aycock KI, Campbell RL, Lynch FC, Manning KB, Craven BA (2016) The importance of hemorheology and patient anatomy on the hemodynamics in the inferior vena cava. Ann Biomed Eng 44(12):3568–3582. doi:10.1007/s10439-016-1663-x. (ISSN: 1573-9686)CrossRef Aycock KI, Campbell RL, Lynch FC, Manning KB, Craven BA (2016) The importance of hemorheology and patient anatomy on the hemodynamics in the inferior vena cava. Ann Biomed Eng 44(12):3568–3582. doi:10.​1007/​s10439-016-1663-x. (ISSN: 1573-9686)CrossRef
go back to reference Aycock KI, Campbell RL, Manning KB, Craven BA (2017a) A resolved two-way coupled CFD/6-DOF approach for predicting embolus transport and the embolus-trapping efficiency of IVC filters. Biomech Model Mechanobiol 16(3):851–869. doi:10.1007/s10237-016-0857-3. (ISSN: 1617-7940)CrossRef Aycock KI, Campbell RL, Manning KB, Craven BA (2017a) A resolved two-way coupled CFD/6-DOF approach for predicting embolus transport and the embolus-trapping efficiency of IVC filters. Biomech Model Mechanobiol 16(3):851–869. doi:10.​1007/​s10237-016-0857-3. (ISSN: 1617-7940)CrossRef
go back to reference Aycock KI, Campbell RL, Lynch FC, Manning KB, Craven BA (2017b) Computational predictions of the embolus-trapping performance of an IVC filter in patient-specific and idealized IVC geometries. Biomech Model Mechanobiol 1–13. doi:10.1007/s10237-017-0931-5. (ISSN: 1617-7940) Aycock KI, Campbell RL, Lynch FC, Manning KB, Craven BA (2017b) Computational predictions of the embolus-trapping performance of an IVC filter in patient-specific and idealized IVC geometries. Biomech Model Mechanobiol 1–13. doi:10.​1007/​s10237-017-0931-5. (ISSN: 1617-7940)
go back to reference Budwig R (1994) Refractive index matching methods for liquid flow investigations. Exp Fluids 17(5):350–355. doi:10.1007/bf01874416. (ISSN: 1432-1114) Budwig R (1994) Refractive index matching methods for liquid flow investigations. Exp Fluids 17(5):350–355. doi:10.​1007/​bf01874416. (ISSN: 1432-1114)
go back to reference Büsen M, Kaufmann TA, Neidlin M, Steinseifer U, Sonntag SJ (2015) In vitro flow investigations in the aortic arch during cardiopulmonary bypass with stereo-PIV. J Biomech 48(10):2005–2011. doi:10.1016/j.jbiomech.2015.03.030. (ISSN: 0021-9290) Büsen M, Kaufmann TA, Neidlin M, Steinseifer U, Sonntag SJ (2015) In vitro flow investigations in the aortic arch during cardiopulmonary bypass with stereo-PIV. J Biomech 48(10):2005–2011. doi:10.​1016/​j.​jbiomech.​2015.​03.​030. (ISSN: 0021-9290)
go back to reference Butscher D, Hutter C, Kuhn S, von Rohr PR (2012) Particle image velocimetry in a foam-like porous structure using refractive index matching: a method to characterize the hydrodynamic performance of porous structures. Exp Fluids 53(4):1123–1132. doi:10.1007/s00348-012-1346-9. (ISSN: 1432-1114) Butscher D, Hutter C, Kuhn S, von Rohr PR (2012) Particle image velocimetry in a foam-like porous structure using refractive index matching: a method to characterize the hydrodynamic performance of porous structures. Exp Fluids 53(4):1123–1132. doi:10.​1007/​s00348-012-1346-9. (ISSN: 1432-1114)
go back to reference Chohan JS, Singh R, Boparai KS, Penna R, Fraternali F (2017) Dimensional accuracy analysis of coupled fused deposition modeling and vapour smoothing operations for biomedical applications. Compos B Eng 117:138–149CrossRef Chohan JS, Singh R, Boparai KS, Penna R, Fraternali F (2017) Dimensional accuracy analysis of coupled fused deposition modeling and vapour smoothing operations for biomedical applications. Compos B Eng 117:138–149CrossRef
go back to reference de Zélicourt D, Pekkan K, Kitajima H, Frakes D, Yoganathan AP (2005) Single-step stereolithography of complex anatomical models for optical flow measurements. J Biomech Eng 127(1):204. doi:10.1115/1.1835367. (ISSN 0148-0731) de Zélicourt D, Pekkan K, Kitajima H, Frakes D, Yoganathan AP (2005) Single-step stereolithography of complex anatomical models for optical flow measurements. J Biomech Eng 127(1):204. doi:10.​1115/​1.​1835367. (ISSN 0148-0731)
go back to reference Doorly D, Taylor DJ, Franke P, Schroter RC (2008) Experimental investigation of nasal airflow. Proc Inst Mech Eng Part H J Eng Med 222(4):439–453. doi:10.1243/09544119jeim330. (ISSN 2041-3033) Doorly D, Taylor DJ, Franke P, Schroter RC (2008) Experimental investigation of nasal airflow. Proc Inst Mech Eng Part H J Eng Med 222(4):439–453. doi:10.​1243/​09544119jeim330. (ISSN 2041-3033)
go back to reference Ford MD, Nikolov HN, Milner JS, Lownie SP, DeMont EM, Kalata W, Loth F, Holdsworth DW, Steinman DA (2008) PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models. J Biomech Eng 130(2):021015. doi:10.1115/1.2900724. (ISSN: 0148-0731) Ford MD, Nikolov HN, Milner JS, Lownie SP, DeMont EM, Kalata W, Loth F, Holdsworth DW, Steinman DA (2008) PIV-measured versus CFD-predicted flow dynamics in anatomically realistic cerebral aneurysm models. J Biomech Eng 130(2):021015. doi:10.​1115/​1.​2900724. (ISSN: 0148-0731)
go back to reference Geoghegan PH, Buchmann NA, Spence CJT, Moore S, Jermy M (2012) Fabrication of rigid and flexible refractive-index-matched flow phantoms for flow visualisation and optical flow measurements. Exp Fluids 52(5):1331–1347. doi:10.1007/s00348-011-1258-0. (ISSN 1432-1114) Geoghegan PH, Buchmann NA, Spence CJT, Moore S, Jermy M (2012) Fabrication of rigid and flexible refractive-index-matched flow phantoms for flow visualisation and optical flow measurements. Exp Fluids 52(5):1331–1347. doi:10.​1007/​s00348-011-1258-0. (ISSN 1432-1114)
go back to reference Hopkins LM, Kelly JT, Wexler AS, Prasad AK (2000) Particle image velocimetry measurements in complex geometries. Exp Fluids 29(1):91–95. doi:10.1007/s003480050430. (ISSN: 1432-1114) Hopkins LM, Kelly JT, Wexler AS, Prasad AK (2000) Particle image velocimetry measurements in complex geometries. Exp Fluids 29(1):91–95. doi:10.​1007/​s003480050430. (ISSN: 1432-1114)
go back to reference Ionita CN, Mokin M, Varble N, Bednarek DR, Xiang J, Snyder KV, Siddiqui AH, Levy EI, Meng H, Rudin S (2014) Challenges and limitations of patient-specific vascular phantom fabrication using 3D polyjet printing. In: SPIE medical imaging, International Society for optics and photonics, pp 90380M–90380M Ionita CN, Mokin M, Varble N, Bednarek DR, Xiang J, Snyder KV, Siddiqui AH, Levy EI, Meng H, Rudin S (2014) Challenges and limitations of patient-specific vascular phantom fabrication using 3D polyjet printing. In: SPIE medical imaging, International Society for optics and photonics, pp 90380M–90380M
go back to reference Kim BJ, Ha H, Huh HK, Kim GB, Kim JS, Kim N, Lee S-J, Kang D-W, Kwon SU (2016) Post-stenotic recirculating flow may cause hemodynamic perforator infarction. J Stroke 18(1):66–72. doi:10.5853/jos.2015.01445. (ISSN: 2287-6405) Kim BJ, Ha H, Huh HK, Kim GB, Kim JS, Kim N, Lee S-J, Kang D-W, Kwon SU (2016) Post-stenotic recirculating flow may cause hemodynamic perforator infarction. J Stroke 18(1):66–72. doi:10.​5853/​jos.​2015.​01445. (ISSN: 2287-6405)
go back to reference Kim SK, Chung SK (2004) An investigation on airflow in disordered nasal cavity and its corrected models by tomographic PIV. Meas Sci Technol 15(6):1090–1096. doi:10.1088/0957-0233/15/6/007. (ISSN: 1361-6501) Kim SK, Chung SK (2004) An investigation on airflow in disordered nasal cavity and its corrected models by tomographic PIV. Meas Sci Technol 15(6):1090–1096. doi:10.​1088/​0957-0233/​15/​6/​007. (ISSN: 1361-6501)
go back to reference Kumbhar NN, Mulay AV (2016) Post processing methods used to improve surface finish of products which are manufactured by additive manufacturing technologies: a review. J Inst Eng (India) Ser C. doi:10.1007/s40032-016-0340-z. (ISSN: 2250-0553) Kumbhar NN, Mulay AV (2016) Post processing methods used to improve surface finish of products which are manufactured by additive manufacturing technologies: a review. J Inst Eng (India) Ser C. doi:10.​1007/​s40032-016-0340-z. (ISSN: 2250-0553)
go back to reference Lara M, Chen C-Y, Mannor P, Dur O, Menon PG, Yoganathan AP, Pekkan K (2011) Hemodynamics of the hepatic venous three-vessel confluences using particle image velocimetry. Ann Biomed Eng 39(9):2398–2416. doi:10.1007/s10439-011-0326-1. (ISSN: 1573-9686) Lara M, Chen C-Y, Mannor P, Dur O, Menon PG, Yoganathan AP, Pekkan K (2011) Hemodynamics of the hepatic venous three-vessel confluences using particle image velocimetry. Ann Biomed Eng 39(9):2398–2416. doi:10.​1007/​s10439-011-0326-1. (ISSN: 1573-9686)
go back to reference Lowe M, Kutt P (1992) Refraction through cylindrical tubes. Exp Fluids 13(5):315–320CrossRef Lowe M, Kutt P (1992) Refraction through cylindrical tubes. Exp Fluids 13(5):315–320CrossRef
go back to reference Mediratta R, Ahluwalia K, Yeo SH (2015) State-of-the-art on vibratory finishing in the aviation industry: an industrial and academic perspective. Int J Adv Manuf Technol 85(1-4):415–429. doi:10.1007/s00170-015-7942-0. (ISSN: 1433-3015) Mediratta R, Ahluwalia K, Yeo SH (2015) State-of-the-art on vibratory finishing in the aviation industry: an industrial and academic perspective. Int J Adv Manuf Technol 85(1-4):415–429. doi:10.​1007/​s00170-015-7942-0. (ISSN: 1433-3015)
go back to reference Narrow T, Yoda M, Abdel-Khalik S (2000) A simple model for the refractive index of sodium iodide aqueous solutions. Exp Fluids 28(3):282–283CrossRef Narrow T, Yoda M, Abdel-Khalik S (2000) A simple model for the refractive index of sodium iodide aqueous solutions. Exp Fluids 28(3):282–283CrossRef
go back to reference Park JS, Choi CK, Kihm KD (2004) Optically sliced micro-piv using confocal laser scanning microscopy (clsm). Exp Fluids 37(1):105–119. doi:10.1007/s00348-004-0790-6. (ISSN: 1432-1114) Park JS, Choi CK, Kihm KD (2004) Optically sliced micro-piv using confocal laser scanning microscopy (clsm). Exp Fluids 37(1):105–119. doi:10.​1007/​s00348-004-0790-6. (ISSN: 1432-1114)
go back to reference Pekkan K, Zélicourt DD, Ge L, Sotiropoulos F, Frakes D, Fogel MA, Yoganathan AP (2005) Physics-driven CFD modeling of complex anatomical cardiovascular flows: a TCPC case study. Ann Biomed Eng 33(3):284–300. doi:10.1007/s10439-005-1731-0. (ISSN: 1573-9686) Pekkan K, Zélicourt DD, Ge L, Sotiropoulos F, Frakes D, Fogel MA, Yoganathan AP (2005) Physics-driven CFD modeling of complex anatomical cardiovascular flows: a TCPC case study. Ann Biomed Eng 33(3):284–300. doi:10.​1007/​s10439-005-1731-0. (ISSN: 1573-9686)
go back to reference Rahbar E, Mori D, Moore JE (2011) Three-dimensional analysis of flow disturbances caused by clots in inferior vena cava filters. J Vasc Interv Radiol 22(6):835–842. doi:10.1016/j.jvir.2010.12.024. (ISSN 1051-0443) Rahbar E, Mori D, Moore JE (2011) Three-dimensional analysis of flow disturbances caused by clots in inferior vena cava filters. J Vasc Interv Radiol 22(6):835–842. doi:10.​1016/​j.​jvir.​2010.​12.​024. (ISSN 1051-0443)
go back to reference Rumple C (2014) Particle image velocimetry measurements of flow in an anatomically-accurate scaled model of the rodent nasal cavity. Master’s thesis, The Pennsylvania State University Rumple C (2014) Particle image velocimetry measurements of flow in an anatomically-accurate scaled model of the rodent nasal cavity. Master’s thesis, The Pennsylvania State University
Metadata
Title
Particle image velocimetry measurements in an anatomical vascular model fabricated using inkjet 3D printing
Authors
Kenneth I. Aycock
Prasanna Hariharan
Brent A. Craven
Publication date
01-11-2017
Publisher
Springer Berlin Heidelberg
Published in
Experiments in Fluids / Issue 11/2017
Print ISSN: 0723-4864
Electronic ISSN: 1432-1114
DOI
https://doi.org/10.1007/s00348-017-2403-1

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