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Journal of Nanoparticle Research

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01-11-2018 | Research Paper

PEGylated polyethylenimine-stabilized polypyrrole nanoparticles loaded with DOX for chemo-photothermal therapy of cancer cells

Authors: Shuhang Lan, Weicheng Xie, Jingjing Wang, Jie Hu, Wei Tang, Wenting Yang, Xiangrong Yu, Hui Liu

Published in: Journal of Nanoparticle Research | Issue 11/2018

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Abstract

Combination of kinds of therapy modalities is promising for effective cancer treatment. Herein, a kind of multifunctional nanoparticles (NPs) was developed for cancer chemo-photothermal therapy applications. Polypyrrole (PPy) NPs were formed using a facile polymerization method using poly(ethyleneimine) (PEI) as stabilizer, followed by polyethylene glycol (PEG) modification and anticancer drug doxorubicin (DOX) loading. Showing obvious absorbance in the NIR range, the obtained PPy-PEI-PEG NPs displayed well photothermal ability with desirable photothermal stability. The release of the loaded DOX can be promoted by pH and laser stimulation. Compared with single therapy modality, the combination of chemotherapy and photothermal therapy showed higher cancer cell killing effect. The cellular internalization of the obtained NPs was proved to be effective. The developed multifunctional NPs are promising candidates for combined therapy of cancer cells.

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Title: PEGylated polyethylenimine-stabilized polypyrrole nanoparticles loaded with DOX for chemo-photothermal therapy of cancer cells
Authors: Shuhang Lan
Weicheng Xie
Jingjing Wang
Jie Hu
Wei Tang
Wenting Yang
Xiangrong Yu
Hui Liu
Publication date: 01-11-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 11/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4418-9

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