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Journal of Nanoparticle Research

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01-11-2018 | Research Paper

Shape controlled quantum dot (QD)-decorated-mesoporous SiO₂ (m-SiO₂/QD) hollow particles for photodynamic therapy

Authors: Jingyu Si, Jianfeng Zhang, Jinyu Duan, Huajian Xu, Qunling Fang

Published in: Journal of Nanoparticle Research | Issue 11/2018

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Abstract

This work reported a novel kind of CdTe quantum dot (QD) decorated mesoporous SiO₂ (m-SiO₂/QD) hybrid hollow nanoparticles for carrying photodynamic therapy (PDT) reagent. Both rod-like and spherical nanoparticles were prepared by using different shaped templates. Due to the porous shell and hollow interior, the hybrid m-SiO₂/QD hollow nanorod with 360 nm long and 120 nm in diameter was selected for carrying zinc(II) phthalocyanine (ZnPc) photosensitizing molecules (61 mg/g) since the generated reactive ¹O₂ could be easily delivered out of the hollow particles through the porous shell (BET area 251 cm²/g). It was found that the m-SiO₂/QD-ZnPc hollow nanorods exhibited a good PDT activity and showed effective photocytotoxicity for the cancer cells. Because of the porous nature, fluorescence characteristic, and excellent storage ability, the m-SiO₂/QD hybrid hollow particles possessed broad potential in the fluorescent labeled PDT.

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Bai L, Zhao QF, Wang J, Gao YK, Sha Z, Di DH, Han N, Wang Y, Zhang JH, Wang SL (2015) Mechanism study on pH-responsive cyclodextrin capped mesoporous silica: effect of different stalk densities and the type of cyclodextrin. Nanotechnology 26:165704CrossRef

Di Corato R, Bealle G, Kolosnjaj-Tabi J, Espinosa A, Clement O, Silva AKA, Menager C, Wilhelm C (2015) Combining magnetic hyperthermia and photodynamic therapy for tumor ablation with photoresponsive magnetic liposomes. ACS Nano 9:2904–2916CrossRef

Dolmans D, Fukumura D, Jain RK (2003) Photodynamic therapy for cancer. Nat Rev Cancer 3:380–387CrossRef

Fang QL, Zhang XY, Xu HJ, Qian HS, Xuan SH (2016) Preparation of highly photoluminescent CdTe nanocrystals in a mixing alkali medium. Chem Lett 45:535–537CrossRef

Gao Y, Qiao GM, Zhuo LH, Li N, Liu Y, Tang B (2011) A tumor mRNA-mediated bi-photosensitizer molecular beacon as an efficient imaging and photosensitizing agent. Chem Commun 47:5316–5318CrossRef

Ge J, Hu Y, Biasini M, Beyermann WP, Yin Y (2007) Superparamagnetic magnetite colloidal nanocrystal clusters. Angew Chem Int Ed 46:4342–4345CrossRef

Gong H, Cheng L, Xiang J, Xu H, Feng LZ, Shi XZ, Liu Z (2013) Near-infrared absorbing polymeric nanoparticles as a versatile drug carrier for cancer combination therapy. Adv Funct Mater 23:6059–6067CrossRef

Gui RJ, Wan AJ, Jin H (2013) Facile synthesis of quantum dots/mesoporous silica/quantum dots core/shell/shell hybrid microspheres for ratiometric fluorescence detection of 5-fluorouracil in human serum. Analyst 138:5956–5964CrossRef

Hou L, Yuan YJ, Ren JX, Zhang YL, Wang YC, Shan XN, Liu Q, Zhang ZZ (2017) In vitro and in vivo comparative study of the phototherapy anticancer activity of hyaluronic acid-modified single-walled carbon nanotubes, graphene oxide, and fullerene. J Nanopart Res 19:286CrossRef

Jang YS, Kim SJ, Oh WK, Kim CH, Lee I, Jang JS (2014) A folic acid conjugated silica-titania porous hollow nanosphere for improved topical photodynamic therapy. Chem Commun 50:15345–15347CrossRef

Jiang JZ, Ng DKP (2009) A decade journey in the chemistry of sandwich-type tetrapyrrolato-rare earth complexes. Acc Chem Res 42:79–88CrossRef

Kim S, Ohulchanskyy TY, Pudavar HE, Pandey RK, Prasad PN (2007) Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. J Am Chem Soc 129:2669–2675CrossRef

Kim HJ, Shin KJ, Han MK, An KJ, Lee JK, Honmab I, Kimc HS (2009) One-pot synthesis of multifunctional mesoporous silica nanoparticle incorporated with zinc(II) phthalocyanine and iron oxide. Scr Mater 61:1137–1140CrossRef

Lee Y, Baron ED (2011) Photodynamic therapy: current evidence and applications in dermatology. Semin Cutan Med Surg 30:199–209CrossRef

Li ZL, Han J, Yu LD, Qian XQ, Xing H, Lin H, Wu MC, Yang T, Chen Y (2018) Synergistic sonodynamic/chemotherapeutic suppression of hepatocellular carcinoma by targeted biodegradable mesoporous nanosonosensitizers. Adv Funct Mater 28:1800145CrossRef

Liu CY, Guo J, Yang WL, Hu JH, Wang CC, Fu SK (2009) Magnetic mesoporous silica microspheres with thermo-sensitive polymer shell for controlled drug release. J Mater Chem 19:4764–4770CrossRef

Liu J, Zhou BR, Yi F, Wu HJ, Zhang JA, Luo D (2016) Pyogenic granuloma in a patient with psoriasis successfully treated by 5-aminolevulinic acid photodynamic therapy: a case report. Exp Ther Med 11:345–347CrossRef

Lu KD, He CB, Lin WB (2014) Nanoscale metal-organic framework for highly effective photodynamic therapy of resistant head and neck cancer. J Am Chem Soc 136:16712–16715CrossRef

Mao Y, Jiang WQ, Xuan SH, Fang QL, Leung KCF, Ong BS, Wang S, Gong XL (2015) Rod-like beta-FeOOH@poly(dopamine)-Au-poly(dopamine) nanocatalysts with improved recyclable activities. Dalton Trans 44:9538–9544CrossRef

Moan J (1986) Porphyrin photosensitization and phototherapy. Photochem Photobiol 43:681–688CrossRef

Qian HS, Guo HC, Ho PCL, Mahendran R, Zhang Y (2009) Mesoporous-silica-coated up-conversion fluorescent nanoparticles for photodynamic therapy. Small 5:2285–2290CrossRef

Qiao XF, Zhou JC, Xiao JW, Wang YF, Sun LD, Yan CH (2012) Triple-functional core-shell structured upconversion luminescent nanoparticles covalently grafted with photosensitizer for luminescent, magnetic resonance imaging and photodynamic therapy in vitro. Nanoscale 4:4611–4623CrossRef

Qiu ZL, Shu J, Tang DP (2017) Bioresponsive release system for visual fluorescence detection of carcinoembryonic antigen from mesoporous silica nanocontainers mediated optical color on quantum dot-enzyme-impregnated paper. Anal Chem 89:5152–5160CrossRef

Secret E, Maynadier M, Gallud A, Gary-Bobo M, Chaix A, Belamie E, Maillard P, Sailor MJ, Garcia M, Durand JO, Cunin F (2013) Anionic porphyrin-grafted porous silicon nanoparticles for photodynamic therapy. Chem Commun 49:4202–4204CrossRef

Senge MO, Fazekas M, Notaras EGA, Blau WJ, Zawadzka M, Locos OB, Mhuircheartaigh EMN (2007) Nonlinear optical properties of porphyrins. Adv Mater 19:2737–2774CrossRef

Sun Q, You Q, Pang XJ, Tan XX, Wang JP, Liu L, Guo F, Li N (2017) A photoresponsive and rod-shape nanocarrier: single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods. Biomaterials 122:188–200CrossRef

Svenskaya Y, Parakhonskiy B, Haase A, Atkin V, Lukyanets E, Gorin D, Antolini R (2013) Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer. Biophys Chem 182:11–15CrossRef

Tian B, Wang C, Zhang S, Feng L, Liu Z (2011) Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. ACS Nano 5:7000–7009CrossRef

Topel SD, Cin GT, Akkaya EU (2014) Near IR excitation of heavy atom free Bodipy photosensitizers through the intermediacy of upconverting nanoparticles. Chem Commun 50:8896–8899CrossRef

Tuncel S, Dumoulin F, Gailer J, Sooriyaarachchi M, Atilla D, Durmus M, Bouchu D, Savoie H, Boyle RW, Ahsen V (2011) A set of highly water-soluble tetraethyleneglycol-substituted Zn(II) phthalocyanines: synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity. Dalton Trans 40:4067–4079CrossRef

Wang X, Zhang QB, Zhao JW, Dai JW (2013) One-step self-assembly of ZnPc/NaGdF4:Yb,Er nanoclusters for simultaneous fluorescence imaging and photodynamic effects on cancer cells. J Mater Chem B 1:4637–4643CrossRef

Wang MH, Sun ZK, Yue Q, Yang J, Wang XQ, Deng YH, Yu CZ, Zhao DY (2014) An interface-directed coassembly approach to synthesize uniform large-pore mesoporous silica spheres. J Am Chem Soc 136:1884–1892CrossRef

Wong RCH, Chow SYS, Zhao S, Fong WP, Ng DKP, Lo PC (2017) pH-responsive dimeric zinc (II) phthalocyanine in mesoporous silica nanoparticles as an activatable nanophotosensitizing system for photodynamic therapy. ACS Appl Mater Interfaces 9:23487–23496CrossRef

Wu MY, Chen Y, Zhang LX, Li XY, Cai XJ, Du YY, Zhang LL, Shi JL (2015) A salt-assisted acid etching strategy for hollow mesoporous silica/organosilica for pH-responsive drug and gene co-delivery. J Mater Chem B 3:766–775CrossRef

Xia L, Kong X, Liu X, Tu L, Zhang Y, Chang Y, Liu K, Shen D, Zhao H, Zhang H (2014) An upconversion nanoparticle-zinc phthalocyanine based nanophotosensitizer for photodynamic therapy. Biomaterials 35:4146–4156CrossRef

Xiong MH, Bao Y, Yang XZ, Zhu YH, Wang J (2014) Delivery of antibiotics with polymeric particles. Adv Drug Deliv Rev 78:63–76CrossRef

Xuan SH, Wang YXJ, Yu JC, Leung KCF (2009) Tuning the grain size and particle size of superparamagnetic Fe₃O₄ microparticles. Chem Mater 21:5079–5087CrossRef

Yao XX, Niu XX, Ma KX, Huang P, Grothe J, Kaskel S, Zhu YF (2017) Graphene quantum dots-capped magnetic mesoporous silica nanoparticles as a multifunctional platform for controlled drug delivery, magnetic hyperthermia, and photothermal therapy. Small 13:1602225CrossRef

Yin ML, Ju EG, Chen ZW, Li ZH, Ren JS, Qu XG (2014) Upconverting nanoparticles with a mesoporous TiO₂ shell for near-infrared-triggered drug delivery and synergistic targeted cancer therapy. Chem Eur J 20:14012–14017CrossRef

Zhang Q, Zhang TR, Ge JP, Yin YD (2008) Permeable silica shell through surface-protected etching. Nano Lett 8:2867–2871CrossRef

Zhang RR, Li L, Tong LL, Tang B (2013) Enhanced luminescence of photosensitizer-based mesoporous silica nanocomposites via energy transfer from conjugated polymer. Nanotechnology 24:015604CrossRef

Zhang YY, Qu QY, Cao X, Zhao YL (2017) NIR-absorbing dye functionalized hollow mesoporous silica nanoparticles for combined photothermal chemotherapy. Chem Commun 53:12032–12035CrossRef

Zhao WR, Lang MD, Li YS, Li L, Shi JL (2009) Fabrication of uniform hollow mesoporous silica spheres and ellipsoids of tunable size through a facile hard-templating route. J Mater Chem 19:2778–2783CrossRef

Zhao LY, Wang K, Furuyama T, Jiang JZ, Kobayashi N (2014) Synthesis and spectroscopic properties of chiral binaphthyl-linked subphthalocyanines. Chem Commun 50:7663–7665CrossRef

Zhao TC, Nguyen NT, Xie Y, Sun XF, Li Q, Li XM (2017) Inorganic nanocrystals functionalized mesoporous silica nanoparticles: fabrication and enhanced bio-applications. Front Chem 5:118CrossRef

Zhou L, Ge XF, Zhou JH, Wei SH, Shen J (2015) Multicolor imaging and the anticancer effect of a bifunctional silica nanosystem based on the complex of graphene quantum dots and hypocrellin A. Chem Commun 51:421–424CrossRef

Title: Shape controlled quantum dot (QD)-decorated-mesoporous SiO2 (m-SiO2/QD) hollow particles for photodynamic therapy
Authors: Jingyu Si
Jianfeng Zhang
Jinyu Duan
Huajian Xu
Qunling Fang
Publication date: 01-11-2018
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 11/2018
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-018-4415-z

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