nach oben

Journal of Nanoparticle Research

Erschienen in:

01.08.2017 | Research Paper

In vitro and in vivo comparative study of the phototherapy anticancer activity of hyaluronic acid-modified single-walled carbon nanotubes, graphene oxide, and fullerene

verfasst von: Lin Hou, Yujie Yuan, Junxiao Ren, Yinling Zhang, Yongchao Wang, Xiaoning Shan, Qi Liu, Zhenzhong Zhang

Erschienen in: Journal of Nanoparticle Research | Ausgabe 8/2017

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config

KI-gestützte Suche

Aus

Abstract

In this work, carbon nanomaterials, single-walled carbon nanotubes (SWNT), graphene oxide (GO), and fullerene (C60) were modified by hyaluronic acid (HA) to obtain water-soluble and biocompatible nanomaterials with high tumor-targeting capacity and then the comparative study of these hyaluronic acid-modified carbon nanomaterials was made in vitro and in vivo. The conjugates of hyaluronic acid and carbon nanomaterials, namely, HA-SWNT, HA-GO, HA-C60, were confirmed by UV/Vis spectrum, Fourier transform infrared spectroscopy (FTIR), and a transmission electron microscope (TEM). After HA modification, the sizes of HA-SWNT, HA-GO, and HA-C60 were in a range of 70 to 300 nm, and all the three HA-modified materials were at negative potential, demonstrating that HA modification was in favor of extravasation of carbon materials into a tumor site due to enhanced permeability and retention effect of tumor. Photothermal conversion in vitro test demonstrated excellent photothermal sensitivity of HA-SWNT and HA-GO. But the reactive oxygen yield of HA-C60 was the highest compared with the others under visible light irradiation, which proved the good photodynamic therapy effect of HA-C60. In addition, cytotoxicity experiments exhibited that the inhibitory efficacy of HA-SWNT was the lowest, the second was HA-C60, and the highest was HA-GO, which was consistent with the uptake degree of them. While under the laser irradiation, the cell inhibition of the HA-SWNT was the highest, the second was HA-GO, and the last was HA-C60. In vivo evaluation of the three targeting carbon nanomaterials was consistent with the cytotoxicity assay results. Taken together, the results demonstrated that HA-SWNT and HA-GO were suited for photothermal therapy (PTT) agents for their good photothermal property, while HA-C60 was used as a kind of photodynamic therapy (PDT) agent for its photodynamic effect.

Vorheriger Artikel Synthesis and microstructure of Co/Ni: MgGa2O4 nanoparticles

Nächster Artikel Taylor dispersion of nanoparticles

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Afreen S, Muthoosamy K, Manickam S et al (2015) Functionalized fullerene (C60) as a potential nanomediator in the fabrication of highly sensitive biosensors. Biosens Bioelectron 63:354–364CrossRef

Assanhou AG, Li WY, Zhang L et al (2015) Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment. Biomaterials 73:284–229CrossRef

Bhana S, O’Connor R, Johnson J et al (2016) Photosensitizer-loaded gold nanorods for near infrared photodynamic and photothermal cancer therapy. J Colloid Interface Sci 469:8–16CrossRef

Cao XY, Tao L, Wen SH et al (2015) Hyaluronic acid-modified multiwalled carbon nanotubes for targeted delivery of doxorubicin into cancer cells. Carbohydr Res 405:70–77CrossRef

Chauhan G, Chopra V, Tyagi A et al (2017) “Gold nanoparticles composite-folic acid conjugated graphene oxide nanohybrids” for targeted chemo-thermal cancer ablation: in vitro screening and in vivo studies. Eur J Pharm Sci 96:351–361CrossRef

Chen JQ, Liu HY, Zhao CB et al (2014) One-step reduction and PEGylation of graphene oxide for photothermally controlled drug delivery. Biomaterials 35:4986–4995CrossRef

Choi KY, Min KH, Yoon HY et al (2011a) PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo. Biomaterials 32:1880–1889CrossRef

Choi WI, Kim J-Y, Kang C et al (2011b) Tumor regression in vivo by photothermal therapy based on gold-nanorod-loaded functional nanocarriers. ACS Nano 5:1995–2003CrossRef

Datir SR, Das M, Singh RP et al (2012) Hyaluronate tethered, “smart” multiwalled carbon nanotubes for tumor-targeted delivery of doxorubicin. Bioconjug Chem 23:2201–2213CrossRef

Deni E, Zamarrón A, Bonaccorsi P et al (2016) Glucose-functionalized amino-OPEs as biocompatible photosensitizers in PDT. Eur J Med Chem 111:58–71CrossRef

Feng QH, Zhang YY, Zhang WX et al (2016) Tumor-targeted and multi-stimuli responsive drug delivery system for near-infrared light induced chemo-phototherapy and photoacoustic tomography. Acta Biomater 38:129–142CrossRef

Hou L, Feng QH, Wang YT et al (2015) Multifunctional nanosheets based on hyaluronic acid modified graphene oxide for tumor-targeting chemophotothermal therapy. J Nanopart Res 17:162–178CrossRef

Kim S, Lee DJ, Kwag DS et al (2014) Acid pH-activated glycol chitosan/fullerene nanogels for efficient tumor therapy. Carbohydr Polym 101:692–698CrossRef

Kwag DS, Park K, Oh KT et al (2012) Hyaluronated fullerenes with photoluminescent and antitumoral activity. Chem Commun 49:282–284CrossRef

Lee J-Y, Termsarasab U, Park J-H et al (2016) Dual CD44 and folate receptor-targeted nanoparticles for cancer diagnosis and anticancer drug delivery. J Control Release 236:38–46CrossRef

Li J, Huo MR, Wang J et al (2012) Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel. Biomaterials 33:2310–2320CrossRef

Li Q, Hong L, Li HG et al (2017) Graphene oxide-fullerene C60 (GO-C60) hybrid for photodynamic and photothermal therapy triggered by near-infrared light. Biosens Bioelectron 89:477–482CrossRef

Li WH, Yi XL, Liu X et al (2016) Hyaluronic acid ion-pairing nanoparticles for targeted tumor therapy. J Control Release 225:170–182CrossRef

Li WM, Su CW, Chen YW et al (2015) In situ DOX-calcium phosphate mineralized CPT-amphiphilic gelatin nanoparticle for intracellular controlled sequential release of multiple drugs. Acta Biomater 15:191–199CrossRef

Liang XY, Shang WT, Chi CW et al (2016) Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging. Cancer Lett 383:243–249CrossRef

Lin CW, Lu KY, Wang SY et al (2016) CD44-specific nanoparticles for redox-triggered reactive oxygen species production and doxorubicin release. Acta Biomater 35:280–292CrossRef

Lin WJ, Lee WC, Shieh MJ (2017) Hyaluronic acid conjugated micelles possessing CD44 targeting potential for gene delivery. Carbohydr Polym 155:101–108CrossRef

Miao WJ, Shim G, Lee S et al (2014) Structure-dependent photothermal anticancer effects of carbon-based photoresponsive nanomaterials. Biomaterials 35:4058–4065CrossRef

Neelgund GM, Oki AR (2016) Influence of carbon nanotubes and graphene nanosheets on photothermal effect of hydroxyapatite. J Colloid Interface Sci 484:135–145CrossRef

Riehemann K, Schneider SW, Luger TA et al (2009) Nanomedicine-challenge and perspectives. Angew Chem Int Ed Engl 48:872–897CrossRef

Sahu A, Choi WI, Lee JH et al (2013) Graphene oxide mediated delivery of methylene blue for combined photodynamic and photothermal therapy. Biomaterials 34:6239–6248CrossRef

Shams M, Owczarczak B, Manderscheid-Kern P (2015) Development of photodynamic therapy regimens that control primary tumor growth and inhibit secondary disease. Cancer Immunol Immunother 64:287–297CrossRef

Sheng ZH, Song L, Zheng JX et al (2013) Protein-assisted fabrication of nano-reduced graphene oxide for combined in vivo photoacoustic imaging and photothermal therapy. Biomaterials 34:5236–5243CrossRef

Shi JJ, Wang BH, Wang L et al (2016) Fullerene (C60)-based tumor-targeting nanoparticles with “off-on” state for enhanced treatment of cancer. J Control Release 235:245–258CrossRef

Tian B, Wang C, Zhang S (2011) Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. ACS Nano 5:7000–7009CrossRef

Veiseh M, Breadner D, Ma J et al (2012) Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes. Biomacromolecules 13:12–22CrossRef

Wang AT, Liang DS, Liu YJ et al (2015) Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors. Biomaterials 53:160–172CrossRef

Wong BS, Yoong SL, Jagusiak A et al (2013) Carbon nanotubes for delivery of small molecule drugs. Adv Drug Deliv Rev 65:1964–2015CrossRef

Yang DZ, Feng LZ, Dougherty CA et al (2016) In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide. Biomaterials 104:361–371CrossRef

Zhang HJ, Hou L, Jiao XJ et al (2015) Transferrin-mediated fullerenes nanoparticles as Fe²⁺-dependent drug vehicles for synergistic anti-tumor efficacy. Biomaterials 37:353–366CrossRef

Zhang YF, He LY, Wu J et al (2016) Switchable PDT for reducing skin photosensitization by a NIR dye inducing self-assembled and photo-disassembled nanoparticles. Biomaterials 107:23–32CrossRef

Zhou MJ, Zhang XJ, Yang YL et al (2013) Carrier-free functionalized multidrug nanorods for synergistic cancer therapy. Biomaterials 34:8960–8967CrossRef

Titel: In vitro and in vivo comparative study of the phototherapy anticancer activity of hyaluronic acid-modified single-walled carbon nanotubes, graphene oxide, and fullerene
verfasst von: Lin Hou
Yujie Yuan
Junxiao Ren
Yinling Zhang
Yongchao Wang
Xiaoning Shan
Qi Liu
Zhenzhong Zhang
Publikationsdatum: 01.08.2017
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 8/2017
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-3977-5

Premium Partner

Marktübersichten

Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen.

Zur Marktübersicht

Springer Professional

Abstract

Bitte loggen Sie sich ein, um Zugang zu Ihrer Lizenz zu erhalten.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Weitere Artikel der Ausgabe 8/2017

Relaxation time: a proton NMR-based approach as a metric to measure reactivity of engineered nanomaterials

Single Particle Extinction and Scattering allows novel optical characterization of aerosols

Fabrication of genetically engineered polypeptide@quantum dots hybrid nanogels for targeted imaging

Patterns from dried water-butanol binary-based nanofluid drops

Exploring the hydrogen absorption into Pd–Ir nanoalloys supported on carbon

Characterization of core/shell Cu/Ag nanopowders synthesized by electrochemistry and assessment of their impact on hemolysis, platelet aggregation, and coagulation on human blood for potential wound dressing use

Premium Partner

Marktübersichten