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06-03-2021 | Communication

Photo-curable, double-crosslinked, in situ-forming hydrogels based on oxidized hydroxypropyl cellulose

Authors: Junyi Chen, Kevin J. Edgar, Charles E. Frazier

Published in: Cellulose | Issue 7/2021

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Abstract

Chemoselective oxidation of oligo(hydroxypropyl)-substituted polysaccharides affords ketones at side chain termini, which readily condense to in situ-forming hydrogels with amine-containing polymers. This type of imine-crosslinked hydrogel displays several interesting and practically valuable properties including injectability, self-healing, tunable moduli, and ability to respond to multiple types of stimulus, so that these are promising materials for biomedical applications. As oligo(hydroxypropyl)-substituted polysaccharides are multi-functional and have the potential to be further chemically modified, a variety of useful motifs and interesting properties can be incorporated into these hydrogel systems. In this study, methacrylate groups were appended to oxidized hydroxypropyl cellulose (Ox-HPC) by esterification, conveying to the hydrogel the ability to be cured by exposure to ultraviolet (UV) radiation and reinforced by this second crosslinking mechanism. Hydrogel modulus was greatly enhanced (from 1800 Pa to 14 kPa) by UV curing. These hydrogels exhibit self-healing and injectability properties both before and after UV curing, suggesting that these materials have promise, including for 3D printing and biomedical applications. Overall, this work demonstrates synthesis, preparation, and photo-responsive properties of methacrylate-functionalized Ox-HPC/Chitosan hydrogels, broadening the family and utility of oligo(hydroxypropyl)-substituted, polysaccharide-based hydrogels.

Graphic abstract

UV-induced crosslinking of acrylated Ox-HPC/chitosan hydrogel.

next article Effect of oxidation on cellulose and water structure: a molecular dynamics simulation study

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Title: Photo-curable, double-crosslinked, in situ-forming hydrogels based on oxidized hydroxypropyl cellulose
Authors: Junyi Chen
Kevin J. Edgar
Charles E. Frazier
Publication date: 06-03-2021
Publisher: Springer Netherlands
Published in: Cellulose / Issue 7/2021
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-021-03788-9

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