Top

Published in:

22-03-2019 | Composites

Polylactic acid/sodium alginate/hydroxyapatite composite scaffolds with trabecular tissue morphology designed by a bone remodeling model using 3D printing

Authors: I. Fernández-Cervantes, M. A. Morales, R. Agustín-Serrano, M. Cardenas-García, P. V. Pérez-Luna, B. L. Arroyo-Reyes, A. Maldonado-García

Published in: Journal of Materials Science | Issue 13/2019

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

The article presents a new methodology that employs 3D printing technology to generate a microporous composite material of polylactic acid, sodium alginate and hydroxyapatite, whose microstructure is designed by means of the 3D numerical solution from a mathematical model. This model represents the spatio-temporal dynamics of the interaction between osteoblasts and osteoclasts in the bone remodeling. The microporosity of composite material mimics the structure of human trabecular bone. This material has density with microporosity pretty close to the one that is exhibited by the natural bone tissue. Close relationship between the material processing and its elasticity module is observed. When subjecting this composite material to a simulated body fluid treatment, the mechanical resistance to compression is increased due to induced mineralization of hydroxyapatite crystals on its surface. The methodology shows potential to generate structures that allow the control of the composite material properties. The material presents a microporosity that has morphological and chemical properties suitable for future applications in tissue engineering as bone scaffold.

previous article Mesoporous amorphous TiO2 shell-coated ZIF-8 as an efficient and recyclable catalyst for transesterification to synthesize diphenyl carbonate

next article One-sided surface charring of beech wood

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Available only for authorised users

Jaffe M, Hammond W, Tolias P, Arinzeh T (2013) Characterization of biomaterials, 1st edn. Woodhead Publishing, OxfordCrossRef

Martin TJ, Ng KW (1994) Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity. J Cell Biochem 56:357–366CrossRef

Rodan GA, Martin TJ (2000) Therapeutic approaches to bone diseases. Science 289:1508–1514CrossRef

Mouriño V, Boccaccini AR (2010) Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds. J R Soc Interface 7:209–227CrossRef

Seitz H, Rieder W, Irsen S, Leukers B, Tille C (2005) Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering. J Biomed Mater Res B Appl Biomater 74:782–788CrossRef

Jones AC, Arns CH, Sheppard AP, Hutmacher DW, Milthorpe BK, Knackstedt MA (2007) Assessment of bone ingrowth into porous biomaterials using MICRO-CT. Biomaterials 28:2491–504CrossRef

Rezwan F, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27:3413–3431CrossRef

Muller B, Deyhle H, Fierz F (2009) Bio-mimetic hollow scaffolds for long bone replacement. Proc SPIE 7401:1–13

Sabir MI, Xu X, Li L (2009) A review on biodegradable polymeric materials for bone tissue engineering applications. J Mater Sci 44:5713–5724. https://doi.org/10.1007/s10853-009-3770-7 CrossRef

10.

Liu Y, Lim J, Teoh SH (2013) Review: development of clinically relevant scaffolds for vascularised bone tissue engineering. Biotechnol Adv 31:688–705CrossRef

11.

Hao Z, Song Z, Huang J, Huang K, Panetta A, Gu Z, Wu J (2017) The scaffold microenvironment for stem cell based bone tissue engineering. Biomater Sci 5:1382–1392CrossRef

12.

Salgado AJ, Coutinho OP, Reis RL (2004) Bone tissue engineering: state of the art and future trends. Macromol Biosci 4:743–765CrossRef

13.

Velasco MA, Lancheros Y, Garzón-Alvarado DA (2016) Geometric and mechanical properties evaluation of scaffolds for bone tissue applications designing by a reaction–diffusion models and manufactured with a material jetting system. J Comput Des Eng 3:385–397

14.

Karageorgiou V, Kaplan D (2005) Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 26:5474–5491CrossRef

15.

Xue W, Krishna BV, Bandyopadhyay A, Bose S (2007) Processing and biocompatibility evaluation of laser processed porous titanium. Acta Biomater 3:1007–1018CrossRef

16.

Otsuki B, Takemoto M, Fujibayashi S, Neo M, Kokubo T, Nakamura T (2006) Pore throat size and connectivity determine bone and tissue ingrowth into porous implants: three-dimensional micro-CT based structural analyses of porous bioactive titanium implants. Biomaterials 27:5892–5900CrossRef

17.

Stoppato M, Carletti E, Sidarovich V, Quattrone A, Unger RE, Kirkpatrick CJ, Migliaresi C, Motta A (2013) Influence of scaffold pore size on collagen I development: a new in vitro evaluation perspective. J Bioact Compat Polym 28:16–32CrossRef

18.

Das K, Bose S, Bandyopadhyay A (2007) Surface modifications and cell-materials interactions with anodized Ti. Acta Biomater 3:573–585CrossRef

19.

Bodhak S, Bose S, Bandyopadhyay A (2009) Role of surface charge and wettability on early stage mineralization and bone cell-materials interactions of polarized hydroxyapatite. Acta Biomater 5:2178–2188CrossRef

20.

Tarafder S, Banerjee S, Bandyopadhyay A, Bose S (2010) Electrically polarized biphasic calcium phosphates: adsorption and release of bovine serum albumin. Langmuir 26:16625–16629CrossRef

21.

Kucharska M, Butruk B, Walenko K, Brynk T, Ciach T (2012) Fabrication of in-situ foamed chitosan/ \({\beta }\)-TCP scaffolds for bone tissue engineering application. Mater Lett 85:124–127CrossRef

22.

Cao H, Kuboyama N (2010) A biodegradable porous composite scaffold of PGA/beta-TCP for bone tissue engineering. Bone 46:386–395CrossRef

23.

Sultana N, Wang M (2008) Fabrication of HA/PHBV composite scaffolds through the emulsion freezing/freeze-drying process and characterisation of the scaffolds. J Mater Sci Mater Med 19:2555–2561CrossRef

24.

Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21:2529–2543CrossRef

25.

Yoshikawa H, Tamai N, Murase T, Myoui A (2009) Interconnected porous hydroxyapatite ceramics for bone tissue engineering. J R Soc Interface 6:S341–S348CrossRef

26.

Bose S, Suguira S, Bandyopadhyay A (1999) Processing of controlled porosity ceramic structures via fused deposition. Scr Mater 41:1009–1014CrossRef

27.

Bose S, Darsell J, Kintner M, Hosick H, Bandyopadhyay A (2003) Pore size and pore volume effects on alumina and TCP ceramic scaffolds. Mater Sci Eng C 23:479–486CrossRef

28.

Gibson I, Rosen D, Stucker B (2015) Additive manufacturing technologies: 3D printing, rapid prototyping, and direct digital manufacturing, 2nd edn. Springer, New YorkCrossRef

29.

Gantenbein S, Masania K, Woigk W, Sesseg JPW, Tervoort TA, Studart AR (2018) Three-dimensional printing of hierarchical liquid-crystal-polymer structures. Nature 561:226–230CrossRef

30.

Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM, Kates SL, Awad HA (2014) 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35:4026–4034CrossRef

31.

Komarova SV, Smith RJ, Dixon SJ, Sims SM, Wahl LM (2003) Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling. Bone 33:206–215CrossRef

32.

Ayati BP, Edwards CM, Webb GF, Wikswo JP (2010) A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease. Biol Direct 5:1–17CrossRef

33.

Felfel RM, Poocza L, Gimeno-Fabra M, Milde T, Hildebrand G, Ahmed I, Scotchford C, Sottile V, Grant DM, Liefeith K (2016) In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization. Biomed Mater 11:1–14CrossRef

34.

Zhu Y, Wan Y, Zhang J, Yin D, Cheng W (2014) Manufacture of layered collagen/chitosan-polycaprolactone scaffolds with biomimetic microarchitecture. Colloids Surf B Biointerfaces 113:352–356CrossRef

35.

Jang IG, Kim IY (2008) Computational study of Wolffs law with trabecular architecture in the human proximal femur using topology optimization. J Biomech 41:2353–2361CrossRef

36.

Tsubota K, Suzuki Y, Yamada T, Hojo M, Makinouchi A, Adachi T (2009) Computer simulation of trabecular remodeling in human proximal femur using large-scale voxel FE models: approach to understanding Wolffs law. J Biomech 42:1088–1094CrossRef

37.

Boyle C, Kim IY (2011) Three-dimensional micro-level computational study of Wolffs law via trabecular bone remodeling in the human proximal femur using design space topology optimization. J Biomech 44:935–942CrossRef

38.

Saber-Samandari S, Saber-Samandari S, Kiyazar S, Aghazadeh J, Sadeghi A (2016) In vitro evaluation for apatite-forming ability of cellulose-based nanocomposite scaffolds for bone tissue engineering. Int J Biol Macromol 86:434–442CrossRef

39.

Vinceković M, Jalśenjak N, Topolovec-Pintarić S, Dermić E, Bujan M, Jurić S (2016) Encapsulation of biological and chemical agents for plant nutrition and protection: chitosan/alginate microcapsules loaded with copper cations and trichoderma viride. J Agric Food Chem 64:8073–8083CrossRef

40.

Koutsopoulos S (2002) Synthesis and characterization of hydroxyapatite crystals: a review study on the analytical methods. J Biomed Mater Res 62:600–612CrossRef

41.

Bett JAS, Christner LG, Hall WK (1967) Hydrogen held by solids. XII. Hydroxyapatite catalysts. J Am Chem Soc 89:5535–5541CrossRef

42.

Sibeko B, Choonara YE, du Toit LC, Modi G, Naidoo D, Khan RA, Kumar P, Ndesendo VMK, Iyuke SE, Pillay V (2012) Composite polylactic-methacrylic acid copolymer nanoparticles for the delivery of methotrexate. J Drug Deliv 2012:1–18CrossRef

43.

Kanasan N, Adzila S, Suid MS, Gurubaran P (2016) Preparation and characterization of hydroxyapatite/sodium alginate biocomposites for bone implant application. In: AIP conference proceedings 1756:020006-1 to 020006-1

44.

Antebi B, Cheng X, Harris JN, Gower LB, Chen X-D, Ling J (2013) Biomimetic collagen hydroxyapatite composite fabricated via a novel perfusion-flow mineralization technique. Tissue Eng Part C Methods 19:487–496CrossRef

45.

Fonseca J (2012) Bone biology: from macrostructure to gene expression. Medicographia 34:142–148

46.

Norman J, Shapter JG, Short K, Smith LJ, Fazzalari NL (2008) Micromechanical properties of human trabecular bone: a hierarchical investigation using nanoindentation. J Biomed Mater Res A 87A:196–202CrossRef

47.

Hing KA (2004) Bone repair in the twenty-first century: biology, chemistry or engineering? Philos. Trans A Math Phys Eng Sci 362:2821–2850CrossRef

48.

Wagoner-Johnson AJ, Herschler BA (2011) A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair. Acta Biomater 7:16–30CrossRef

49.

Brundavanam RK, Poinern GEJ, Fawcett D (2013) Modelling the crystal structure of a 30 nm sized particle based hydroxyapatite powder synthesised under the influence of ultrasound irradiation from X-ray powder diffraction data. Am J Mater Sci 3:84–90

50.

Maciel A, Presbtero G, Pia C, del Pilar Gutiérrez M, Guzmán J, Munguía N (2015) Pore cross-section area on predicting elastic properties of trabecular bovine bone for human implants. Biomed Mater Eng 25:9–23

Title: Polylactic acid/sodium alginate/hydroxyapatite composite scaffolds with trabecular tissue morphology designed by a bone remodeling model using 3D printing
Authors: I. Fernández-Cervantes
M. A. Morales
R. Agustín-Serrano
M. Cardenas-García
P. V. Pérez-Luna
B. L. Arroyo-Reyes
A. Maldonado-García
Publication date: 22-03-2019
Publisher: Springer US
Published in: Journal of Materials Science / Issue 13/2019
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-019-03537-1

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Other articles of this Issue 13/2019

Highly efficient synthesis of N-doped carbon dots with excellent stability through pyrolysis method

Elastocaloric effect with small hysteresis in bamboo-grained Cu–Al–Mn microwires

Effect of RGO coating on lithium storage performance of monodispersed core–shell MoS2 superspheres

Dissipative particle dynamics simulations of centrifugal melt electrospinning

Synthesis of Au-nanoparticle-loaded 1T@2H-MoS2 nanosheets with high photocatalytic performance

Experimental and numerical investigation of interfacial microstructure in fully age-hardened 15-5 PH stainless steel during impact welding

Premium Partners