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23-11-2017 | Original Paper

Preparation and characterization of chitosan–poly(vinyl alcohol)–neomycin sulfate films

Authors: Irina Paula Merlusca, Doina Simona Matiut, Gabriela Lisa, Mihaela Silion, Luiza Gradinaru, Stefan Oprea, Ionel Marcel Popa

Published in: Polymer Bulletin | Issue 9/2018

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Abstract

The aim of our study was obtaining chitosan–poly(vinyl alcohol)–neomycin sulfate films (Cs–PVA–Ne) by using solvent casting technique and the characterization of the products. The films were analyzed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy, thermogravimetry (TG and DTG), differential scanning calorimetry (DSC), contact angle (CA) measurements, mechanical, and antibacterial activity tests. FTIR and DSC analysis demonstrated that interaction between Cs, PVA, and Ne took place. Static water CA measurements showed an improvement in the hydrophilicity of the Cs–PVA–Ne films. Also, the drug-loaded films proved to have fairly good mechanical strength and significant effects against Staphylococcus aureus and Escherichia coli. The unloaded films show minimum bacterial inhibition (~ 10.00 mm) compared to drug-loaded films (~ 30.00 mm). The bacterial inhibition was higher in all the cases of S. aureus than E. coli. Furthermore, PVA was found to improve the films properties. Due to their physical–chemical and mechanical features and the excellent antibacterial properties, the obtained Cs–PVA–Ne films are suitable for their use as wound-dressing materials.

previous article Influence of thiol groups on the ethylene adsorption and conductivity properties of the modified porous clay heterostructures (PCHS) using as ethylene scavenger in smart packaging

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Title: Preparation and characterization of chitosan–poly(vinyl alcohol)–neomycin sulfate films
Authors: Irina Paula Merlusca
Doina Simona Matiut
Gabriela Lisa
Mihaela Silion
Luiza Gradinaru
Stefan Oprea
Ionel Marcel Popa
Publication date: 23-11-2017
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 9/2018
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-017-2246-1

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