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Journal of Polymer Research

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01-08-2014 | Original Paper

Preparation and characterization of novel derivatives of chitosan and trimethyl chitosan conjugated with dipeptides and vitamin B12 as candidates for oral delivery of insulin

Authors: Nersi Jafary Omid, Niloofar Babanejad, Hossein Amini, Mohsen Amini, Morteza Rafiee Tehrani, Farid Dorkoosh

Published in: Journal of Polymer Research | Issue 8/2014

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Abstract

Chitosan and its derivatives are widely used in drug delivery systems due to their bio-degradebility, bio-compatibility and absorption enhancing properties. Many peptide and protein derived therapeutics cannot be administered through oral rout because of the proteolytic condition of gastro-intestinal tract and their low bio-availability. Insulin is a peptide drug which is widely used in diabetics as repeated daily injection. Due to the fact that there are receptors for didpeptides and vitamine B12 in small intestine, in this research work novel derivatives of chitosan and trimethyl chitosan conjugated with glycyl-glycine, alanyl-alaninie and vitamine B12 were synthesized and characterized. The structure of conjugates as well as substitution of different functional groups was confirmed by different instrumental analytical methods such as Fourier transform infrared, magnetic resonance, and X-ray diffraction spectroscopy. Nano-particles of aforementioned loaded with insulin were prepared and their size, surface electrical charge and morphology characterized and their release profile were studied. The results are promising and reveal that these new chitosan and trimethyl chitosan derivatives are potential vehicles for protein and peptide drug molecules.

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Title: Preparation and characterization of novel derivatives of chitosan and trimethyl chitosan conjugated with dipeptides and vitamin B12 as candidates for oral delivery of insulin
Authors: Nersi Jafary Omid
Niloofar Babanejad
Hossein Amini
Mohsen Amini
Morteza Rafiee Tehrani
Farid Dorkoosh
Publication date: 01-08-2014
Publisher: Springer Netherlands
Published in: Journal of Polymer Research / Issue 8/2014
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI: https://doi.org/10.1007/s10965-014-0510-8

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