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23-02-2024 | Original Research

Preparation of fibroblast growth factor 2-incorporated carboxymethyl cellulose nanoparticles for tissue repair and regeneration

Authors: Khanh-Thien Le, Cong-Thuan Nguyen, Le-Giang Thi Nguyen, Long Binh Vong, Thuoc Linh Tran, Hieu Tran-Van

Published in: Cellulose | Issue 5/2024

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Abstract

Fibroblast growth factor 2 (FGF-2) is a protein that plays an important role in the skin wound healing process. However, the biomedical application of this protein has some limitations due to its instability. To address this problem, this study developed carboxymethyl cellulose (CMC) nanoparticles (NPs) as a nano-carrier for FGF-2 encapsulation and stabilization to improve the bioavailability of this therapeutic protein. Using aluminum chloride (AlCl₃) as a cross-linking agent, sphere-shaped CMC NPs were successfully created with a size of 85.60 ± 12.15 nm and no cytotoxicity on NIH/3T3 cell line. In FGF-2 encapsulation, the pre-gelation FGF-2 concentration at 50 μg/mL resulted in the highest FGF-2 loading efficiency at over 90%. FGF-2-incorporated CMC NPs (CMC:FGF-2 NPs) exhibited the same size (88.06 ± 13.51 nm) with CMC NPs, release rates at approximately 30% in aqueous solution after 48 h, preservation of FGF-2 biological activity on NIH/3T3 cell line, and FGF-2 protection from protease hydrolytic action. In burn treatment on mice, CMC:FGF-2 NPs displayed an acceleration of wound closure, growth of granulation tissue, re-epithelialization, and angiogenesis compared to CMC NPs and naked FGF-2. Collectively, this study was a groundwork for the further clinical study of CMC:FGF-2 NPs in burn treatment.

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Abdelhakim M, Lin X, Ogawa R (2020) The japanese experience with basic fibroblast growth factor in cutaneous wound management and scar prevention: a systematic review of clinical and biological aspects. Dermatol Ther (heidelb) 10:569–587. https://doi.org/10.1007/s13555-020-00407-6CrossRefPubMed

Ahmad F, Mushtaq B, Butt FA, Zafar MS, Ahmad S, Afzal A, Nawab Y, Rasheed A, Ulker Z (2021) Synthesis and characterization of nonwoven cotton-reinforced cellulose hydrogel for wound dressings. Polym (basel). https://doi.org/10.3390/polym13234098CrossRef

Allou NB, Yadav A, Pal M, Goswamee RL (2018) Biocompatible nanocomposite of carboxymethyl cellulose and functionalized carbon-norfloxacin intercalated layered double hydroxides. Carbohydr Polym 186:282–289. https://doi.org/10.1016/j.carbpol.2018.01.066CrossRefPubMed

Alminderej FM, Ammar C, El-Ghoul Y (2021) Functionalization, characterization and microbiological performance of new biocompatible cellulosic dressing grafted chitosan and Suaeda fruticosa polysaccharide extract. Cellulose 28:9821–9835. https://doi.org/10.1007/s10570-021-04155-4CrossRef

Altam AA, Zhu L, Babiker D, Yagoub H, Yang S (2022) Loading and releasing behavior of carboxymethyl cellulose and chitosan complex beads. Prog Nat Sci Mater Int 32:715–723. https://doi.org/10.1016/j.pnsc.2022.10.003CrossRef

Arumughan V, Nypelö T, Hasani M, Brelid H, Albertsson S, Wågberg L, Larsson A (2021) Specific ion effects in the adsorption of carboxymethyl cellulose on cellulose: the influence of industrially relevant divalent cations. Coll Surf Physicochem Eng Asp. https://doi.org/10.1016/j.colsurfa.2021.127006CrossRef

Bao N, Miao X, Hu X, Zhang Q, Jie X, Zheng X (2017) Novel synthesis of plasmonic Ag/AgCl@TiO2 continues fibers with enhanced broadband photocatalytic performance. Catalysts. https://doi.org/10.3390/catal7040117CrossRef

Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M (2014) Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen 22:569–578. https://doi.org/10.1111/wrr.12205CrossRefPubMedPubMedCentral

Basu P, Narendrakumar U, Arunachalam R, Devi S, Manjubala I (2018) Characterization and evaluation of carboxymethyl cellulose-based films for healing of full-thickness wounds in normal and diabetic rats. ACS Omega 3:12622–12632. https://doi.org/10.1021/acsomega.8b02015CrossRefPubMedPubMedCentral

Caley MP, Martins VL, O’Toole EA (2015) Metalloproteinases and Wound Healing. Adv Wound Care (new Rochelle) 4:225–234. https://doi.org/10.1089/wound.2014.0581CrossRefPubMed

Cao Y (2018) Applications of cellulose nanomaterials in pharmaceutical science and pharmacology. Express Polym Lett 12:768–780. https://doi.org/10.3144/expresspolymlett.2018.66CrossRef

Chen Y, Cui G, Dan N, Huang Y, Bai Z, Yang C, Dan W (2019) Preparation and characterization of dopamine–sodium carboxymethyl cellulose hydrogel. SN Appl Sci. https://doi.org/10.1007/s42452-019-0605-2CrossRef

Ching YC, Gunathilake TMSU, Chuah CH, Ching KY, Singh R, Liou N-S (2019) Curcumin/Tween 20-incorporated cellulose nanoparticles with enhanced curcumin solubility for nano-drug delivery: characterization and in vitro evaluation. Cellulose 26:5467–5481. https://doi.org/10.1007/s10570-019-02445-6CrossRef

Costa EM, Pereira CF, Ribeiro AA, Casanova F, Freixo R, Pintado M, Ramos OL (2022) Characterization and evaluation of commercial carboxymethyl cellulose potential as an active ingredient for cosmetics. Appl Sci. https://doi.org/10.3390/app12136560CrossRef

Dahlan NA, Teow SY, Lim YY, Pushpamalar J (2021) Modulating carboxymethylcellulose-based hydrogels with superior mechanical and rheological properties for future biomedical applications. Expr Polym Lett 15:612–625. https://doi.org/10.3144/expresspolymlett.2021.52CrossRef

Ding I, Peterson AM (2021) Half-life modeling of basic fibroblast growth factor released from growth factor-eluting polyelectrolyte multilayers. Sci Rep 11:9808. https://doi.org/10.1038/s41598-021-89229-wCrossRefPubMedPubMedCentral

Dolivo DM, Larson SA, Dominko T (2017) FGF2-mediated attenuation of myofibroblast activation is modulated by distinct MAPK signaling pathways in human dermal fibroblasts. J Dermatol Sci 88:339–348. https://doi.org/10.1016/j.jdermsci.2017.08.013CrossRefPubMedPubMedCentral

Ehlers C, Ivens UI, Moller ML, Senderovitz T, Serup J (2001) Females have lower skin surface pH than men. A study on the surface of gender, forearm site variation, right/left difference and time of the day on the skin surface pH. Skin Res Technol 7:90–94. https://doi.org/10.1034/j.1600-0846.2001.70206.xCrossRefPubMed

Enoch S, Leaper DJ (2008) Basic science of wound healing. Surg Infect (larchmt) 26:31–37. https://doi.org/10.1016/j.mpsur.2007.11.005CrossRef

Ferrari G, Pintucci G, Seghezzi G, Hyman K, Galloway AC, Mignatti P (2006) VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis. Proc Natl Acad Sci USA 103:17260–17265. https://doi.org/10.1073/pnas.0605556103CrossRefPubMedPubMedCentral

Fortier SM, Penke LR, King D, Pham TX, Ligresti G, Peters-Golden M (2021) Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions. JCI Insight. https://doi.org/10.1172/jci.insight.144799CrossRefPubMedPubMedCentral

Gaohua L, Miao X, Dou L (2021) Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism, excretion, and toxicity. Expert Opin Drug Metab Toxicol 17:1103–1124. https://doi.org/10.1080/17425255.2021.1951223CrossRefPubMed

Gholamali I (2019) Facile Preparation of Carboxymethyl Cellulose/Cu Bio-Nanocomposite Hydrogels for Controlled Release of Ibuprofen. Regen Eng Transl Med 6:115–124. https://doi.org/10.1007/s40883-019-00133-2CrossRef

Girija Aswathy R, Sivakumar B, Brahatheeswaran D, Raveendran S, Ukai T, Fukuda T, Yoshida Y, Maekawa T, Nair Sakthikumar D (2012) Multifunctional biocompatible fluorescent <i>Carboxymethyl cellulose</i> nanoparticles. J Biomater Nanobiotechnol 03:254–261. https://doi.org/10.4236/jbnb.2012.322031CrossRef

Gough JE, Scotchford CA, Downes S (2002) Cytotoxicity of glutaraldehyde crosslinked collagen/poly(vinyl alcohol) films is by the mechanism of apoptosis. J Biomed Mater Res 61:121–130. https://doi.org/10.1002/jbm.10145CrossRefPubMed

Grazul-Bilska AT, Luthra G, Reynolds LP, Bilski JJ, Johnson ML, Adbullah SA, Redmer DA, Abdullah KM (2002) Effects of basic fibroblast growth factor (FGF-2) on proliferation of human skin fibroblasts in type II diabetes mellitus. Exp Clin Endocrinol Diabetes 110:176–181. https://doi.org/10.1055/s-2002-32149CrossRefPubMed

Ground M, Waqanivavalagi S, Park YE, Callon K, Walker R, Milsom P, Cornish J (2022) Fibroblast growth factor 2 inhibits myofibroblastic activation of valvular interstitial cells. PLoS ONE 17:e0270227. https://doi.org/10.1371/journal.pone.0270227CrossRefPubMedPubMedCentral

Hazra RS, Kale N, Aland G, Qayyumi B, Mitra D, Jiang L, Bajwa D, Khandare J, Chaturvedi P, Quadir M (2020) Cellulose mediated transferrin Nanocages for enumeration of circulating tumor cells for head and neck cancer. Sci Rep 10:10010. https://doi.org/10.1038/s41598-020-66625-2CrossRefPubMedPubMedCentral

Istek A, Bicer A, ÖZLÜSOYLU I (2020) Effect of sodium carboxymethyl cellulose (Na-CMC) added to urea-formaldehyde resinon particleboard properties. Turk J Agric for 44(5):526–532. https://doi.org/10.3906/tar-1905-87CrossRef

Jeong CH, Kim DH, Yune JH, Kwon HC, Shin DM, Sohn H, Lee KH, Choi B, Kim ES, Kang JH, Kim EK, Han SG (2021) In vitro toxicity assessment of crosslinking agents used in hyaluronic acid dermal filler. Toxicol in Vitro 70:105034. https://doi.org/10.1016/j.tiv.2020.105034CrossRefPubMed

Jia T, Jacquet T, Dalonneau F, Coudert P, Vaganay E, Exbrayat-Heritier C, Vollaire J, Josserand V, Ruggiero F, Coll JL, Eymin B (2021) FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells. BMC Biol 19:173. https://doi.org/10.1186/s12915-021-01103-3CrossRefPubMedPubMedCentral

Jirawitchalert S, Mitaim S, Chen CY, Patikarnmonthon N (2022) Cotton cellulose-derived hydrogel and electrospun fiber as alternative material for wound dressing application. Int J Biomater 2022:2502658. https://doi.org/10.1155/2022/2502658CrossRefPubMedPubMedCentral

Jonassen H, Kjoniksen AL, Hiorth M (2012) Stability of chitosan nanoparticles cross-linked with tripolyphosphate. Biomacromol 13:3747–3756. https://doi.org/10.1021/bm301207aCrossRef

Kanikireddy V, Varaprasad K, Jayaramudu T, Karthikeyan C, Sadiku R (2020) Carboxymethyl cellulose-based materials for infection control and wound healing: a review. Int J Biol Macromol 164:963–975. https://doi.org/10.1016/j.ijbiomac.2020.07.160CrossRefPubMed

Kawai K, Suzuki S, Tabata Y, Ikada Y, Nishimura Y (2000) Accelerated tissue regeneration through incorporation of basic fibroblast growth factor-impregnated gelatin microspheres into artificial dermis. Biomaterials 21:489–499. https://doi.org/10.1016/s0142-9612(99)00207-0CrossRefPubMed

Ke Y, Liu GS, Wang JH, Xue W, Du C, Wu G (2014) Preparation of carboxymethyl cellulose based microgels for cell encapsulation. Express Polym Lett 8:841–849. https://doi.org/10.3144/expresspolymlett.2014.85CrossRef

Koike Y, Yozaki M, Utani A, Murota H (2020) Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process. Sci Rep 10:18545. https://doi.org/10.1038/s41598-020-75584-7CrossRefPubMedPubMedCentral

Kumar B, Priyadarshi R, Sauraj DF, Kulshreshtha A, Gaikwad KK, Kim J, Kumar A, Negi YS (2020) Nanoporous sodium carboxymethyl cellulose-g-poly (Sodium Acrylate)/FeCl(3) hydrogel beads: synthesis and characterization. Gels. https://doi.org/10.3390/gels6040049CrossRefPubMedPubMedCentral

Le K-T, Nguyen C-T, Lac T-D, Nguyen L-GT, Tran TL, Tran-Van H (2023) Facilely preparing carboxymethyl chitosan/hydroxyethyl cellulose hydrogel films for protective and sustained release of fibroblast growth factor 2 to accelerate dermal tissue repair. J Drug Deliv Sci Technol. https://doi.org/10.1016/j.jddst.2023.104318CrossRef

Liu Z, Zhang S, Gao C, Meng X, Wang S, Kong F (2022) Temperature/pH-responsive carboxymethyl cellulose/Poly (N-isopropyl acrylamide) interpenetrating polymer network aerogels for drug delivery systems. Polymers (basel). https://doi.org/10.3390/polym14081578CrossRefPubMedPubMedCentral

Lukić M, Pantelić I, Savić SD (2021) Towards optimal pH of the skin and topical formulations: from the current state of the art to tailored products. Cosmetics. https://doi.org/10.3390/cosmetics8030069CrossRef

Maji R, Dey NS, Satapathy BS, Mukherjee B, Mondal S (2014) Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy. Int J Nanomedicine 9:3107–3118. https://doi.org/10.2147/IJN.S63535CrossRefPubMedPubMedCentral

Mansur AAP, de Carvalho FG, Mansur RL, Carvalho SM, de Oliveira LC, Mansur HS (2017) Carboxymethylcellulose/ZnCdS fluorescent quantum dot nanoconjugates for cancer cell bioimaging. Int J Biol Macromol 96:675–686. https://doi.org/10.1016/j.ijbiomac.2016.12.078CrossRefPubMed

McCarty SM, Percival SL (2013) Proteases and delayed wound healing. Adv Wound Care (new Rochelle) 2:438–447. https://doi.org/10.1089/wound.2012.0370CrossRefPubMed

Mitchell AC, Briquez PS, Hubbell JA, Cochran JR (2016) Engineering growth factors for regenerative medicine applications. Acta Biomater 30:1–12. https://doi.org/10.1016/j.actbio.2015.11.007CrossRefPubMed

Mohamad N, Loh EYX, Fauzi MB, Ng MH, Mohd Amin MCI (2019) In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds. Drug Deliv Transl Res 9:444–452. https://doi.org/10.1007/s13346-017-0475-3CrossRefPubMed

Newberry EP, Willis D, Latifi T, Boudreaux JM, Towler DA (1997) Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-AP1 element. Mol Endocrinol 11:1129–1144. https://doi.org/10.1210/mend.11.8.9958CrossRefPubMed

Nguyen CT, Phan HN, Tran-Van H (2015) Establishment of bioactivity assay for recombinant FGF-2 on NIH-3T3 cell line. J Biotechnol 13:7

Nguyen CT, Nguyen TT, Nguyen TT, Nguyen PPT, Nguyen AD, Tran LT, Tran-Van H (2017) Preparation and in vitro evaluation of FGF-2 incorporated carboxymethyl chitosan nanoparticles. Carbohydr Polym 173:114–120. https://doi.org/10.1016/j.carbpol.2017.05.080CrossRefPubMed

Ning J, Luo X, Wang F, Huang S, Wang J, Liu D, Liu D, Chen D, Wei J, Liu Y (2019) Synergetic sensing effect of sodium carboxymethyl cellulose and bismuth on cadmium detection by differential pulse anodic stripping voltammetry. Sensors (basel). https://doi.org/10.3390/s19245482CrossRefPubMedPubMedCentral

Pahimanolis N, Salminen A, Penttilä PA, Korhonen JT, Johansson L-S, Ruokolainen J, Serimaa R, Seppälä J (2013) Nanofibrillated cellulose/carboxymethyl cellulose composite with improved wet strength. Cellulose 20:1459–1468. https://doi.org/10.1007/s10570-013-9923-5CrossRef

Pistone S, Qoragllu D, Smistad G, Hiorth M (2015) Formulation and preparation of stable cross-linked alginate-zinc nanoparticles in the presence of a monovalent salt. Soft Matter 11:5765–5774. https://doi.org/10.1039/c5sm00700cCrossRefPubMed

Pourmadadi M, Rahmani E, Shamsabadipour A, Samadi A, Esmaeili J, Arshad R, Rahdar A, Tavangarian F, Pandey S (2023) Novel carboxymethyl cellulose based nanocomposite: a promising biomaterial for biomedical applications. Process Biochem 130:211–226. https://doi.org/10.1016/j.procbio.2023.03.033CrossRef

Proksch E (2018) pH in nature, humans and skin. J Dermatol 45:1044–1052. https://doi.org/10.1111/1346-8138.14489CrossRefPubMed

Ren X, Zhao M, Lash B, Martino MM, Julier Z (2019) Growth factor engineering strategies for regenerative medicine applications. Front Bioeng Biotechnol 7:469. https://doi.org/10.3389/fbioe.2019.00469CrossRefPubMed

Rodriguez-Navarro C, Linares-Fernandez L, Doehne E, Sebastian E (2002) Effects of ferrocyanide ions on NaCl crystallization in porous stone. J Cryst Growth 243:503–516. https://doi.org/10.1016/s0022-0248(02)01499-9CrossRef

Roy N, Saha N, Humpolicek P, Saha P (2010) Permeability and biocompatibility of novel medicated hydrogel wound dressings. Soft Mater 8:338–357. https://doi.org/10.1080/1539445x.2010.502955CrossRef

Saha B, Patra AS, Mukherjee AK, Paul I (2021) Interaction and thermal stability of carboxymethyl cellulose on alpha-Fe(2)O(3)(001) surface: Reaxff molecular dynamics simulations study. J Mol Graph Model 102:107787. https://doi.org/10.1016/j.jmgm.2020.107787CrossRefPubMed

Salah F, El Ghoul Y, Alminderej FM, El Golli-Bennour E, Ouanes Z, Maciejak O, Jarroux N, Majdoub H, Sakli F (2019) Development, characterization, and biological assessment of biocompatible cellulosic wound dressing grafted Aloe vera bioactive polysaccharide. Cellulose 26:4957–4970. https://doi.org/10.1007/s10570-019-02419-8CrossRef

Seddiqi H, Oliaei E, Honarkar H, Jin J, Geonzon LC, Bacabac RG, Klein-Nulend J (2021) Cellulose and its derivatives: towards biomedical applications. Cellulose 28:1893–1931. https://doi.org/10.1007/s10570-020-03674-wCrossRef

Seghezzi G, Patel S, Ren CJ, Gualandris A, Pintucci G, Robbins ES, Shapiro RL, Galloway AC, Rifkin DB, Mignatti P (1998) Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 141:1659–1673. https://doi.org/10.1083/jcb.141.7.1659CrossRefPubMedPubMedCentral

Seo HR, Jeong HE, Joo HJ, Choi SC, Park CY, Kim JH, Choi JH, Cui LH, Hong SJ, Chung S, Lim DS (2016) Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system. Sci Rep 6:28832. https://doi.org/10.1038/srep28832CrossRefPubMedPubMedCentral

Shi HX, Lin C, Lin BB, Wang ZG, Zhang HY, Wu FZ, Cheng Y, Xiang LJ, Guo DJ, Luo X, Zhang GY, Fu XB, Bellusci S, Li XK, Xiao J (2013) The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo. PLoS ONE 8:e59966. https://doi.org/10.1371/journal.pone.0059966CrossRefPubMedPubMedCentral

Supanakorn G, Taokaew S, Phisalaphong M (2021) Ternary composite films of natural rubber, cellulose microfiber, and carboxymethyl cellulose for excellent mechanical properties, biodegradability and chemical resistance. Cellulose 28:8553–8566. https://doi.org/10.1007/s10570-021-04082-4CrossRef

Tabata Y, Ikada Y (1999) Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. Biomaterials 20:2169–2175. https://doi.org/10.1016/s0142-9612(99)00121-0CrossRefPubMed

Torres FG, Commeaux S, Troncoso OP (2012) Biocompatibility of bacterial cellulose based biomaterials. J Funct Biomater 3:864–878. https://doi.org/10.3390/jfb3040864CrossRefPubMedPubMedCentral

Tran TAT, Nguyen TMT, Tran-Van H (2015) Purification of recombinant human fibroblast growth factor-2 from one-liter fermentation broth. Sci Technol Dev J 18:14–22. https://doi.org/10.32508/stdj.v18i1.1030CrossRef

Tran-Nguyen TM, Le KT, Nguyen LT, Tran TT, Hoang-Thai PC, Tran TL, Tan SL, Tran-Van H (2020) Third-degree burn mouse treatment using recombinant human fibroblast growth factor 2. Growth Factors 38:282–290. https://doi.org/10.1080/08977194.2021.1967342CrossRefPubMed

Wang K, Hazra RS, Ma Q, Khan MRH, Al Hoque A, Jiang L, Quadir M, Zhang Y, Wang S, Han G (2023) Robust biocompatible bacterial cellulose/silk nonwoven fabric/silk sericin sandwich membrane with strong UV-blocking and antioxidant properties. Cellulose 30:3973–3993. https://doi.org/10.1007/s10570-023-05102-1CrossRef

Yadollahi M, Namazi H, Barkhordari S (2014) Preparation and properties of carboxymethyl cellulose/layered double hydroxide bionanocomposite films. Carbohydr Polym 108:83–90. https://doi.org/10.1016/j.carbpol.2014.03.024CrossRefPubMed

Yang XH, Zhu WL (2007) Viscosity properties of sodium carboxymethylcellulose solutions. Cellulose 14:409–417. https://doi.org/10.1007/s10570-007-9137-9CrossRef

Yasui H, Andoh A, Bamba S, Inatomi O, Ishida H, Fujiyama Y (2004) Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts. Digestion 69:34–44. https://doi.org/10.1159/000076545CrossRefPubMed

Title: Preparation of fibroblast growth factor 2-incorporated carboxymethyl cellulose nanoparticles for tissue repair and regeneration
Authors: Khanh-Thien Le
Cong-Thuan Nguyen
Le-Giang Thi Nguyen
Long Binh Vong
Thuoc Linh Tran
Hieu Tran-Van
Publication date: 23-02-2024
Publisher: Springer Netherlands
Published in: Cellulose / Issue 5/2024
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-024-05779-y

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