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2019 | OriginalPaper | Chapter

Present and Future in Personalized Clinical and Laboratory Approaches to In Vitro Fertilization Procedures

Authors : Anđelka Radojčić Badovinac, Neda Smiljan Severinski, Sanja Dević Pavlić

Published in: Personalized Medicine in Healthcare Systems

Publisher: Springer International Publishing

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Abstract

Personalized approach to a patient engaged into an infertility treatment has been present since the early beginnings of the assisted reproductive technologies, and is constantly developing because of the progress of therapy, medication and laboratory methods. Personalization of the infertility treatment can be discussed on three different levels: approach to the patient, selection of gametes and assessment of embryos. Personalization of the approach to the patient includes adjustment of controlled ovarian stimulation strategy as well as usage of the biomarkers for the ovarian response to the hormone stimulation. Regarding gametes and embryo assessment, personalization includes application of novel OMICS and other high-throughput methods for selection of the oocytes and/or embryos with the highest developmental potential. Personalization of the treatment approaches and ovarian stimulation protocols along with improved laboratory techniques would lead to better treatment efficiency with improved safety for the patient, higher percentage of babies born per cycle and higher cumulative live birth rate for couple in shorter period of time.

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Gameiro et al. (2012).

Broer et al. (2011, 2013).

Ferraretti et al. (2011), La Marca et al. (2015), and Polyzos et al. (2014).

Drakopoulos et al. (2016).

Simoni and Casarini (2014).

Mohiyiddeen et al. (2012).

Benkhalifa et al. (2015), Bromer and Seli (2008), and Uyar et al. (2013).

Rienzi et al. (2012).

Revelli et al. (2009).

Dumesic et al. (2015).

Egea et al. (2014).

Chronowska (2014).

Gardner et al. (2001), and Gardner (2015).

Kaser and Racowsky (2014).

Ravichandran et al. (2017).

Benkhalifa M, Madkour A et al (2015) From global proteome profiling to single targeted molecules of follicular fluid and oocyte: contribution to embryo development and IVF outcome. Expert Rev Proteomics 12(4):407–423. https://doi.org/10.1586/14789450.2015.1056782CrossRef

Broer SL, Dólleman M et al (2011) AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update 17(1):46–54. https://doi.org/10.1093/humupd/dmq034CrossRef

Broer SL, Dólleman M et al (2013) Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis. Fertil Steril 100(2):420–429. https://doi.org/10.1016/j.fertnstert.2013.04.024CrossRef

Bromer JG, Seli E (2008) Assessment of embryo viability in assisted reproductive technology: shortcomings of current approaches and the emerging role of metabolomics. Curr Opin Obstet Gynecol 20(3):234–241. https://doi.org/10.1097/GCO.0b013e3282fe723dCrossRef

Chronowska E (2014) High-throughput analysis of ovarian granulosa cell transcriptome. Biomed Res Int 2014:213570. https://doi.org/10.1155/2014/213570CrossRef

Drakopoulos P, Blockeel C et al (2016) Conventional ovarian stimulation and single embryo transfer for IVF/ICSI. How many oocytes do we need to maximize cumulative live birth rates after utilization of all fresh and frozen embryos? Hum Reprod 31(2):370–376. https://doi.org/10.1093/humrep/dev316CrossRef

Dumesic DA, Meldrum DR et al (2015) Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health. Fertil Steril 103(2):303–316. https://doi.org/10.1016/j.fertnstert.2014.11.015CrossRef

Egea RR, Puchalt NG et al (2014) OMICS: current and future perspectives in reproductive medicine and technology. J Hum Reprod Sci 7(2):73–92. https://doi.org/10.4103/0974-1208.138857CrossRef

Ferraretti AP, La Marca A et al (2011) ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod 26(7):1616–1624. https://doi.org/10.1093/humrep/der092CrossRef

Gameiro S, Boivin J et al (2012) Why do patients discontinue fertility treatment? A systematic review of reasons and predictors of discontinuation in fertility treatment. Hum Reprod Update 18(6):652–669. https://doi.org/10.1093/humupd/dms031CrossRef

Gardner DK (2015) Lactate production by the mammalian blastocyst: manipulating the microenvironment for uterine implantation and invasion? BioEssays 37(4):364–371. https://doi.org/10.1002/bies.201400155CrossRef

Gardner DK, Lane M et al (2001) Noninvasive assessment of human embryo nutrient consumption as a measure of developmental potential. Fertil Steril 76(6):1175–1180CrossRef

Kaser DJ, Racowsky C (2014) Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: a systematic review. Hum Reprod Update 20(5):617–631. https://doi.org/10.1093/humupd/dmu023CrossRef

La Marca A, Grisendi V et al (2015) Live birth rates in the different combinations of the Bologna criteria poor ovarian responders: a validation study. J Assist Reprod Genet 32(6):931–937. https://doi.org/10.1007/s10815-015-0476-4CrossRef

Mohiyiddeen L, Newman WG et al (2012) Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers. Fertil Steril 97(3):677–681. https://doi.org/10.1016/j.fertnstert.2011.12.040CrossRef

Polyzos NP, Nwoye M et al (2014) Live birth rates in Bologna poor responders treated with ovarian stimulation for IVF/ICSI. Reprod Biomed Online 28(4):469–474. https://doi.org/10.1016/j.rbmo.2013.11.010CrossRef

Ravichandran K, McCaffrey C et al (2017) Mitochondrial DNA quantification as a tool for embryo viability assessment: retrospective analysis of data from single euploid blastocyst transfers. Hum Reprod 6:1–11. https://doi.org/10.1093/humrep/dex070CrossRef

Revelli A, Delle Piane L et al (2009) Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics. Reprod Biol Endocrinol 7:40. https://doi.org/10.1186/1477-7827-7-40CrossRef

Rienzi L, Balaban B et al (2012) The oocyte. Hum Reprod 1:i2–i121. https://doi.org/10.1093/humrep/des200CrossRef

Simoni M, Casarini L (2014) Mechanisms in endocrinology: genetics of FSH action: a 2014-and-beyond view. Eur J Endocrinol 170(3):R91–R107. https://doi.org/10.1530/EJE-13-0624CrossRef

Uyar A, Torrealday S et al (2013) Cumulus and granulosa cell markers of oocyte and embryo quality. Fertil Steril 99(4):979–997. https://doi.org/10.1016/j.fertnstert.2013.01.129CrossRef

Title: Present and Future in Personalized Clinical and Laboratory Approaches to In Vitro Fertilization Procedures
Authors: Anđelka Radojčić Badovinac
Neda Smiljan Severinski
Sanja Dević Pavlić
Publisher: Springer International Publishing
Book: Personalized Medicine in Healthcare Systems
Print ISBN: 978-3-030-16464-5

Electronic ISBN: 978-3-030-16465-2

Copyright Year: 2019
DOI: https://doi.org/10.1007/978-3-030-16465-2_8