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2021 | OriginalPaper | Chapter

Probing Vasculature by In Vivo Phage Display for Target Organ-Specific Delivery in Regenerative Medicine

Authors : Toini Pemmari, Tiia Koho, Tero A. H. Järvinen

Published in: Vascularization for Tissue Engineering and Regenerative Medicine

Publisher: Springer International Publishing

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Abstract

Different mammalian tissues in their normal and pathological state have distinct molecular features in the luminal side of the vessels. These features can be targeted with peptides that concentrate, i.e., home to their target tissue. The homing peptides can be used to deliver cargo, such as therapeutic molecules, to the target tissue, or they can help in detecting pathological changes in the tissue. Some of the homing peptides are capable of penetrating to the target tissue and bringing their cargo with them. One of the most studied homing peptides, iRGD, penetrates to its target tissue with the help of the CendR sequence. The homing and penetrating peptides are discovered by screening a peptide library encoded on the surface of bacteriophages. In in vivo biopanning, the library is injected to the circulation of a living animal, and later, unbound phages are washed off during circulation and bound phages are eluted from the target tissue. The eluted phages are amplified and form the library for the second biopanning round. After a few rounds, the phages containing sequences that home to the target tissue are concentrated in the library.

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Title: Probing Vasculature by In Vivo Phage Display for Target Organ-Specific Delivery in Regenerative Medicine
Authors: Toini Pemmari
Tiia Koho
Tero A. H. Järvinen
Publisher: Springer International Publishing
Book: Vascularization for Tissue Engineering and Regenerative Medicine
Print ISBN: 978-3-319-54584-4

Electronic ISBN: 978-3-319-54586-8

Copyright Year: 2021
DOI: https://doi.org/10.1007/978-3-319-54586-8_21