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Journal of Sol-Gel Science and Technology
Published in: Journal of Sol-Gel Science and Technology 1/2014

01-10-2014 | Brief Communcation:

Rice husk ash nanosilica to inhibit human breast cancer cell line (3T3)

Authors: R. Yuvakkumar, A. Joseph Nathanael, V. Rajendran, S. I. Hong

Published in: Journal of Sol-Gel Science and Technology | Issue 1/2014

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Abstract

NaOH treatment on phase, purity and particle size of rice husk nanosilica were investigated employing alkaline-extraction–acid-precipitation method. Mild reaction at lower NaOH (1.5 N) revealed small and fine particles (600 nm) due to moderate reaction rate. Morphology of human breast cancer cell line (3T3) revealed that suggestive cell distress effects were more pronounced at 500 µg/ml silica dosages which are in agreement with cell viability decrease (~50 %). Among different silica dosages, 10 µg/ml was found to have highest cell viability (∼70 ± 2 %) capable of increasing dissolved oxygen level while viability was almost decreased to 27 ± 5 % due to toxic effect caused at higher SiO2 dosage and could be a potential candidate best suited for biomedical applications through development of sustainable materials.
previous article Erratum to: Sol–gel synthesis and characterization of SiO2–TaC nanocomposites with controlled volume fraction

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Metadata
Title
Rice husk ash nanosilica to inhibit human breast cancer cell line (3T3)
Authors
R. Yuvakkumar
A. Joseph Nathanael
V. Rajendran
S. I. Hong
Publication date
01-10-2014
Publisher
Springer US
Published in
Journal of Sol-Gel Science and Technology / Issue 1/2014
Print ISSN: 0928-0707
Electronic ISSN: 1573-4846
DOI
https://doi.org/10.1007/s10971-014-3455-9

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